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Article

Piceatannol Protects Brain Endothelial Cell Line (bEnd.3) against Lipopolysaccharide-Induced Inflammation and Oxidative Stress

by
Yan Zhou
1,
Haroon Khan
2,
Maggie Pui Man Hoi
1 and
Wai San Cheang
1,*
1
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
2
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
*
Author to whom correspondence should be addressed.
Molecules 2022, 27(4), 1206; https://doi.org/10.3390/molecules27041206
Submission received: 31 December 2021 / Revised: 4 February 2022 / Accepted: 7 February 2022 / Published: 11 February 2022
(This article belongs to the Special Issue Bioactive Molecules Targeting Inflammation and Oxidative Stress Processes in Related Diseases)
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Abstract

Dysfunction of the blood–brain barrier (BBB) is involved in the pathogenesis of many cerebral diseases. Oxidative stress and inflammation are contributing factors for BBB injury. Piceatannol, a natural ingredient found in various plants, such as grapes, white tea, and passion fruit, plays an important role in antioxidant and anti-inflammatory responses. In this study, we examined the protective effects of piceatannol on lipopolysaccharide (LPS) insult in mouse brain endothelial cell line (bEnd.3) cells and the underlying mechanisms. The results showed that piceatannol mitigated the upregulated expression of adhesion molecules (ICAM-1 and VCAM-1) and iNOS in LPS-treated bEnd.3 cells. Moreover, piceatannol prevented the generation of reactive oxygen species in bEnd.3 cells stimulated with LPS. Mechanism investigations suggested that piceatannol inhibited NF-κB and MAPK activation. Taken together, these observations suggest that piceatannol reduces inflammation and oxidative stress through inactivating the NF-κB and MAPK signaling pathways on cerebral endothelial cells in vitro.
Keywords: piceatannol; inflammation; oxidative stress; brain endothelial cells; lipopolysaccharide piceatannol; inflammation; oxidative stress; brain endothelial cells; lipopolysaccharide

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MDPI and ACS Style

Zhou, Y.; Khan, H.; Hoi, M.P.M.; Cheang, W.S. Piceatannol Protects Brain Endothelial Cell Line (bEnd.3) against Lipopolysaccharide-Induced Inflammation and Oxidative Stress. Molecules 2022, 27, 1206. https://doi.org/10.3390/molecules27041206

AMA Style

Zhou Y, Khan H, Hoi MPM, Cheang WS. Piceatannol Protects Brain Endothelial Cell Line (bEnd.3) against Lipopolysaccharide-Induced Inflammation and Oxidative Stress. Molecules. 2022; 27(4):1206. https://doi.org/10.3390/molecules27041206

Chicago/Turabian Style

Zhou, Yan, Haroon Khan, Maggie Pui Man Hoi, and Wai San Cheang. 2022. "Piceatannol Protects Brain Endothelial Cell Line (bEnd.3) against Lipopolysaccharide-Induced Inflammation and Oxidative Stress" Molecules 27, no. 4: 1206. https://doi.org/10.3390/molecules27041206

APA Style

Zhou, Y., Khan, H., Hoi, M. P. M., & Cheang, W. S. (2022). Piceatannol Protects Brain Endothelial Cell Line (bEnd.3) against Lipopolysaccharide-Induced Inflammation and Oxidative Stress. Molecules, 27(4), 1206. https://doi.org/10.3390/molecules27041206

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