Bioactive Molecules Targeting Inflammation and Oxidative Stress Processes in Related Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 48013
Special Issue Editors
Interests: spectroscopy; chromatography; mass spectrometry; plant bioactive compounds; antioxidant activity; oxidative stress and inflammation; cardiovascular diseases
Special Issues, Collections and Topics in MDPI journals
Interests: cardiovascular toxicology; calcium homeostasis; clinical pharmacology; oxidative stress; inflammation
Special Issues, Collections and Topics in MDPI journals
Interests: ultrasound imaging; ultrasonography; heart failure; internal medicine; cardiovascular disease; metabolic syndrome; pharmacology; cardiology; pharmacodynamics; atherosclerosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is already known that prolonged chronic inflammation influences the development of several chronic diseases such as cancer, cardiovascular, respiratory, and metabolic diseases, Alzheimer’s disease, arthrosis and others. During chronic inflammation, mediators such as cytokines, chemokines, oxidants, eicosanoids or lytic enzymes are released from immune cells, being actively involved in the progression and development of inflammatory processes. The transcription factor NF-κB has a pivotal role since it regulates pro-inflammatory gene expression, including the genes encoding cytokine and chemokine production. An incorrect NF-kB regulation will induce prolonged inflammation, acting as a central transcription factor, which is highly important in chronic inflammatory disease development. Additionally, cyclooxygenase (COX) and lipoxygenase (LOX) are some of the principal enzymes that mediate the inflammation process. The production of prostaglandins (PGEs) and thromboxane is dependent on arachidonic acid COX catalyzation, while the production of leukotrienes (LTs) is dependent on LOX activity. Furthermore, during normal inflammatory metabolic processes, neutrophils and macrophages produce reactive oxygen species (ROS) such as hydrogen peroxide (H2O2), hypochlorous acid (HOCl-), superoxide radical (O2•-), peroxynitrite (ONOO) and nitric oxide (NO). During chronic inflammation, prolonged ROS production can lead to oxidative stress, which is considered central in the progression of inflammatory diseases. An increased ROS production in the absence of specific protective mechanisms will initiate intracellular signalling of specific proinflammatory genes expression, which will eventually lead to chronic inflammation.
Knowing that both inflammation and oxidative stress processes are strongly linked and involved in the initiation and maintenance of many pathological conditions, their prevention and control must be the target in obtaining efficient management of chronic diseases.
In this regard, alternative therapies involving natural bioactive molecules that are able to specifically target the oxidative stress and inflammation processes could provide efficacy along with a good safety profile. That is why they are on the research pipe of many scientists around the world. Thus, bioactive molecules could be considered an ideal approach to the limitations of classical therapy. This Special Issue will focus on phytochemical antioxidants and anti-inflammatory activities, as well as their role in the treatment and management of related diseases.
Dr. Ing. Raluca Maria Pop
Dr. Ada Popolo
Dr. Stefan Cristian Vesa
Guest Editors
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Keywords
- Cardiovascular diseases
- Bioactive molecules
- Oxidative stress
- Inflammation
- Natural products
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