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Volume 30
Issue 8
10.3390/molecules30081848
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Microenvironment Self-Adaptive Ce-Ag-Doped Mesoporous Silica Nanomaterials (CA@MSNs) for Multidrug-Resistant Bacteria-Infected Diabetic Wound Treatment

by
Wuhao Yang
1,
Hui Yuan
2,3,
Hao Sun
2,3,
Jiangshan Hu
2,3,
Yaping Xu
4,
Yuhang Li
2,3,4,* and
Yan Qiu
5,6,*
1
College of Materials, Xiamen University, Xiamen 361005, China
2
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
3
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institutes, Chinese Academy of Sciences, Xiamen 361021, China
4
Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Province University, Xiamen 361023, China
5
School of Medicine, Xiamen University, Xiamen 361102, China
6
Xiamen Key Laboratory of Chiral Drugs, Xiamen 361102, China
*
Authors to whom correspondence should be addressed.
Molecules 2025, 30(8), 1848; https://doi.org/10.3390/molecules30081848 (registering DOI)
Submission received: 17 March 2025 / Revised: 3 April 2025 / Accepted: 17 April 2025 / Published: 20 April 2025
(This article belongs to the Special Issue Recent Advances in Porous Materials, 2nd Edition)
Versions Notes

Abstract

Chronic wound healing remains a major challenge in diabetes management due to prolonged inflammation, autonomic neuropathy, and bacterial infections. In particular, multidrug-resistant bacterial infections are important to the development of diabetic wounds, leading to persistent inflammation and delayed healing. To address this issue, we developed a self-adaptive nanozyme designed to modulate infectious and inflammatory microenvironments by doping Ce and Ag into mesoporous silicon nanomaterials (MSNs). The resulting CA@MSNs exhibited strong bacterial capture capabilities via electrostatic attraction. Additionally, the synergistic effects of Ce and Ag endowed CA@MSNs with peroxidase (POD)-like activity, enabling the generation of reactive oxygen species (ROS) to eradicate bacteria in infectious microenvironments. Notably, CA@MSNs also demonstrated the ability to scavenge a broad spectrum of ROS, including hydroxyl free radicals, hydrogen peroxide, and superoxide radicals, in inflammatory microenvironments. This dual functionality helped mitigate inflammation and promote endothelial cell migration. Consequently, treatment with CA@MSNs significantly reduced inflammation, enhanced fibroblast activation, and facilitated collagen deposition, ultimately accelerating the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in diabetic mice. In conclusion, this study presents a promising therapeutic strategy for chronic diabetic wounds, offering a novel approach to overcoming infection-related healing delays.
Keywords: diabetic wound treatment; reactive oxygen species (ROS); nanozyme; anti-inflammation; antibacteria diabetic wound treatment; reactive oxygen species (ROS); nanozyme; anti-inflammation; antibacteria

Share and Cite

MDPI and ACS Style

Yang, W.; Yuan, H.; Sun, H.; Hu, J.; Xu, Y.; Li, Y.; Qiu, Y. Microenvironment Self-Adaptive Ce-Ag-Doped Mesoporous Silica Nanomaterials (CA@MSNs) for Multidrug-Resistant Bacteria-Infected Diabetic Wound Treatment. Molecules 2025, 30, 1848. https://doi.org/10.3390/molecules30081848

AMA Style

Yang W, Yuan H, Sun H, Hu J, Xu Y, Li Y, Qiu Y. Microenvironment Self-Adaptive Ce-Ag-Doped Mesoporous Silica Nanomaterials (CA@MSNs) for Multidrug-Resistant Bacteria-Infected Diabetic Wound Treatment. Molecules. 2025; 30(8):1848. https://doi.org/10.3390/molecules30081848

Chicago/Turabian Style

Yang, Wuhao, Hui Yuan, Hao Sun, Jiangshan Hu, Yaping Xu, Yuhang Li, and Yan Qiu. 2025. "Microenvironment Self-Adaptive Ce-Ag-Doped Mesoporous Silica Nanomaterials (CA@MSNs) for Multidrug-Resistant Bacteria-Infected Diabetic Wound Treatment" Molecules 30, no. 8: 1848. https://doi.org/10.3390/molecules30081848

APA Style

Yang, W., Yuan, H., Sun, H., Hu, J., Xu, Y., Li, Y., & Qiu, Y. (2025). Microenvironment Self-Adaptive Ce-Ag-Doped Mesoporous Silica Nanomaterials (CA@MSNs) for Multidrug-Resistant Bacteria-Infected Diabetic Wound Treatment. Molecules, 30(8), 1848. https://doi.org/10.3390/molecules30081848

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