2000 July - 24 articles
Trimethyl(trifluorovinyl)silane was prepared [1] without characterization details from bromotrifluoroethylene, which is not commercially available.[...]
5-(2-Thienylidene)barbituric acid 3 was prepared by Knoevenagel condensation of thiophene- 2-carboxaldehyde 1 and barbituric acid 2 in ethanol using piperidine as a base [1,2].[...]
Following the procedure of Takahashi, et al (1), to a mixture of 1-iodo-4-nitrobenzene (7.76 mmol, 1.90g) and 1-octyne (9.3 mmol, 1.023g) in diethylamine (40 mL) are added bis[triphenylphosphine]palladium dichloride (0.2mmol, 0.14g) and copper(I) iod...
Several perinaphthenone/phenylphenalenone compounds were synthesized to establish a relationship between structure and antifungal activity against Mycosphaerella fijiensis. Substitutions on the unsaturated carbonyl system or addition of a phenyl grou...
The book entitiled Pharmacophore Perception, Development, and Use in Drug Design, which has been just released [1], is the first monograph dedicated to the topic of the pharmacophore.[...]
Organic synthesis on solid supports is a rapidly developing methodology, which offers several advantages if compared to traditional synthesis in solution.[...]
Thin layer chromatography (TLC) is a powerful, fast and inexpensive analytical method.[...]
Carbon and Hydrogen: the two basic building units can be combined in a million different ways to give a plethora of fascinating organic compounds.[...]
Cyclohexa-2,4-diene-1-one sulfone derivate undergoes ring cleavage to afford bis-amides containing a diene moiety on irradiation with visible light in the presence of various diamines.
The carbonyl group is undoubtedly one of the most important functional groups in organic chemistry, both in its role as reactive center for synthesis or derivatisation and as crucial feature for special structural or physiological properties.[...]
An improved selective ipso-nitration of the tripropoxy derivative of tertbutylcalix[4]arene at the upper rim is described. The synthesized products are key intermediates for construction of molecular receptors based on calixarenes.
The synthesis of N-Fmoc-L-serine amide was performed by the well known Schotten-Baumann acylation method [1].[...]
Continuing our studies of the Espeletia barclayana Cuatr.[...]
A mixture of 4.28 mmol (1.1328 g) bibenzil-4,4-di-yl-diisocyanate (1) [1] and 84 mmol (6.14 g) of redistilled N,N-dimethylformamide (2) was refluxed under stirring using a magnetically stirring-bar for 12 h, with complete absorption for any carbon di...
The starting imidazole diester (1) was prepared by esterification of the corresponding dicarboxylic acid acccording to the literature procedure [1,2].[...]
A mixture of 3.71 mmol (0.98 g) of bibenzil-2,2-di-yl-diisocyanate (1) [1] and 74.16mmol (5.42 g) of redistilled N,N-dimethylformamide (2) was refluxed under stirring for 8 h, with complete absorption of any carbon dioxide in aqueous potassium hydrox...
Imine and amine ligands have been widely used in the field of transition metal catalyzed olefin polymerization [1].[...]
When the imine-amine compound, bis[(2-benzylideneimino)phenyl]amine [1], is heated in presence of a transition metal salt (for example FeCl3), a reaction occur leading to a new compound.[...]
Electron impact mass spectra of variety of eight 4-substituted and eight 5-substituted benzoselenadiazoles are presented and their spectral fragmentations are discussed. New mass spectra containing selenium in heterocyclic azole atom containing ring.
Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of new non-steroidal anti-inflammatory drugs (NSAID). 3D-QSAR studies have been performed on a series of 1,5-diarylpyrazoles that act as selective cycloox...
Reaction of dimethyl disulfide (1) with cyclohexene (2a) in AcOH in the presence of Pd(OAc)2 yields trans-1-acetoxy-2-methylcyclohexane (3a). The equivalent reactions with hex-1-ene (2b) and 2-methylpent-1-ene (2c) or 1-methylcyclohex-1-ene (2d) pref...
Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl)...
Substituent increments for the calculation of 1H- and 13C-NMR spectra and the MS characteristics of 2,7-naphthyridines substituted on one ring are presented.
Pyrrolidino[3,4-c]pyrazoline and pyrazole derivatives were synthesized via reactions of a substituted hydrazonoyl bromide with N-arylmaleimides and active methylene reagents, respectively. Synthesized pyrazoles were reacted with hydrazine hydrate to...
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