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Volume 23
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10.3390/ijms232012224
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Article

Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats

by
Alexandra V. Griflyuk
,
Tatyana Y. Postnikova
and
Aleksey V. Zaitsev
*
Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, 44, Toreza Prospekt, 194223 Saint Petersburg, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(20), 12224; https://doi.org/10.3390/ijms232012224
Submission received: 31 August 2022 / Revised: 2 October 2022 / Accepted: 11 October 2022 / Published: 13 October 2022
(This article belongs to the Special Issue Roles of Glia in CNS: Toward the Development of New Antidepressant Strategies?)
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Abstract

Prolonged neonatal febrile seizures (FSs) often lead to cognitive decline and increased risk of psychopathology in adulthood. However, the neurobiological mechanisms underlying the long-term adverse effects of FSs remain unclear. In this study, we exposed rat pups to hyperthermia and induced FSs lasting at least 15 min. We investigated the short-term (one day) and delayed (11–13 and 41–45 days) effects of FSs on some parameters of morphological and functional maturation in the hippocampus. We noticed that FSs altered the developmental pattern of glial fibrillary acidic protein (GFAP) immunoreactivity. In rats aged 21–23 days, GFAP-positive astrocytes covered a smaller area, and their morphological characteristics resembled those of rats at 11 days of age. In post-FS rats, the magnitude of long-term synaptic potentiation was reduced compared to control animals of the same age. Applying the gliotransmitter D-serine, an agonist of the glycine site of NMDA receptors, restored LTP to control values. A decrease in LTP amplitude was correlated with impaired spatial learning and memory in the Barnes maze task in post-FS rats. Our data suggest that impaired neuron–glia interactions may be an essential mechanism of the adverse effects of FS on the developing brain.
Keywords: febrile seizures; hyperthermia; long-term potentiation; astrocyte; hippocampus febrile seizures; hyperthermia; long-term potentiation; astrocyte; hippocampus

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MDPI and ACS Style

Griflyuk, A.V.; Postnikova, T.Y.; Zaitsev, A.V. Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats. Int. J. Mol. Sci. 2022, 23, 12224. https://doi.org/10.3390/ijms232012224

AMA Style

Griflyuk AV, Postnikova TY, Zaitsev AV. Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats. International Journal of Molecular Sciences. 2022; 23(20):12224. https://doi.org/10.3390/ijms232012224

Chicago/Turabian Style

Griflyuk, Alexandra V., Tatyana Y. Postnikova, and Aleksey V. Zaitsev. 2022. "Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats" International Journal of Molecular Sciences 23, no. 20: 12224. https://doi.org/10.3390/ijms232012224

APA Style

Griflyuk, A. V., Postnikova, T. Y., & Zaitsev, A. V. (2022). Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats. International Journal of Molecular Sciences, 23(20), 12224. https://doi.org/10.3390/ijms232012224

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