Involvement of circRNAs in the Development of Heart Failure
Abstract
:1. Introduction
2. Biogenesis and Functions of circRNAs
3. CircRNAs in the Development of Heart Failure
3.1. Myocardial Infarction
3.2. Diabetic Cardiomyopathy
3.3. Cardiac Hypertrophy
3.4. Cardiac Fibrosis
3.5. Autophagy and Apoptosis
4. Conclusions
5. Future Directions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Diabetic Cardiomyopathy | |||||
---|---|---|---|---|---|
CircRNAs | Expression | Targets | Place of Action | Effect | References |
CircBPTF | ↑ | miR-384 ↓ | Endothelial cells | Endothelial dysfunction | [65,66] |
CircRNA_000203 | ↑ | miR-26b-5p ↓ | Myocardial fibroblasts | Fibrosis | [67] |
CircRNA_010567 | ↑ | miR-141 ↓ | Myocardial fibroblasts | Fibrosis | [68] |
CACR | ↑ | miR-214-3p ↓ | Cardiomiocytes | Inflammation Pyroptosis Apoptosis | [69] |
CircRNAs | Expression | Targets | Subcellular Localization | Affected Pathway | Effect | References |
---|---|---|---|---|---|---|
Cardiac hypertrophy | ||||||
Circ-HRCR | ↓ | miR-223 | Cytoplasm | ARC axis | Reduces hypertrophy and heart failure | [70] |
CircRNA_000203 | ↑ | miR-140-3p or miR-26b-5p | Cytoplasm | GATA4 axis | Exacerbates cardiac hypertrophy Excludes the anti-fibrotic effect of miR-26b in mouse CFs | [72] [67] |
CiRS-7 | ↑ | miR-7 | Cytoplasm | PARP/SP1 | Worsens cardiac function | [53] |
Cardiac fibrosis | ||||||
CircNF1B | ↓ | miR-433 | Cytoplasm | Fibroblast proliferation | Supports protection against cardiac fibrosis, attenuates fibrosis of cardiac | [79] |
CircHIPK3 | ↑ | miR-29b-3p or miR-17-3p | Cytoplasm | ADCY6 axis | Advances fibrosis of cardiac by up-regulating fibrosis-associated genes | [80,91] |
CircRNA_010567 | ↑ | miR-141/TGF | Cytoplasm | β1 axis | Reduces fibrosis-associated Col I, Col III and α-SMA protein expression | [68] |
CircRNA_005647 | ↓ | miR-27b-3p | Cytoplasm | DAPK | Reduces expressions of fibrosis-related genes | [81] |
Circ_LAS1L | ↓ | miR-125b | Cytoplasm | SFRP5 axis | Reduces the activation, proliferation and migration of cardiac fibroblasts | [92] |
CircPAN3 | ↑ | miR-221 | Cytoplasm | FoxO3/TG7 | Advances cardiac fibrosis post-MI | [93] |
Autophagy and apoptosis | ||||||
CircACR | ↓ | Pink1 | Cytoplasm | FAM65B axis | Extinguish autophagy to attenuate myocardial ischemia/reperfusion injury | [85] |
Circ-MFACR | ↑ | miR-652-3p | Cytoplasm | MTP18 axis | Advances mitochondrial fission and cardiomyocyte apoptosis | [71] |
Circ_Ttc3 | ↓ | miR-15b | Cytoplasm | Arl2 axis | Causes cardioprotection by reducing cardiomyocyte apoptosis | [49] |
CircFndc3b | ↑ | RNA binding protein | Nucleus | FUS/ VEGF-A axis | Extinguish cardiomyocyte apoptosis, improves neovascularization and pick up left ventricular function in post-MI events | [48] |
CircNfix | ↑ | miR-214 | Cytoplasm | YBX1/NEDD4L | Extinguish cardiomyocyte proliferation, angiogenesis and increases CM apoptosis | [22] |
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Sygitowicz, G.; Sitkiewicz, D. Involvement of circRNAs in the Development of Heart Failure. Int. J. Mol. Sci. 2022, 23, 14129. https://doi.org/10.3390/ijms232214129
Sygitowicz G, Sitkiewicz D. Involvement of circRNAs in the Development of Heart Failure. International Journal of Molecular Sciences. 2022; 23(22):14129. https://doi.org/10.3390/ijms232214129
Chicago/Turabian StyleSygitowicz, Grażyna, and Dariusz Sitkiewicz. 2022. "Involvement of circRNAs in the Development of Heart Failure" International Journal of Molecular Sciences 23, no. 22: 14129. https://doi.org/10.3390/ijms232214129