The Impact of Sub-Millisecond Damage Fixation Kinetics on the In Vitro Sparing Effect at Ultra-High Dose Rate in UNIVERSE
Abstract
:1. Introduction
2. Results
2.1. Modeling the Sub-Milliseconds Kinetics of Damage Fixation in UNIVERSE
2.2. Resulting O2 Depletion in UNIVERSE vs. Experimental Data in the Literature
2.3. Recalculation of Previous Benchmarks
3. Discussion
4. Conclusions
5. Materials and Methods
5.1. Experimental Data from Literature
5.2. Modeling Approach
Author Contributions
Funding
Conflicts of Interest
Abbreviations
LET | Linear energy transfer |
SDR | Standard dose rate |
uHDR | Ultra high dose rate |
UNIVERSE | UNIfied and VERSatile bio response Engine |
DSB | (DNA) Double strand break |
iDSB | Isolated DSB |
cDSB | Complex DSB |
OER | Oxygen enhancement ratio |
HRF | Hypoxia reduction factor |
CHO | Chinese hamster ovary |
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---|---|---|---|---|---|---|---|
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Liew, H.; Mein, S.; Tessonnier, T.; Abdollahi, A.; Debus, J.; Dokic, I.; Mairani, A. The Impact of Sub-Millisecond Damage Fixation Kinetics on the In Vitro Sparing Effect at Ultra-High Dose Rate in UNIVERSE. Int. J. Mol. Sci. 2022, 23, 2954. https://doi.org/10.3390/ijms23062954
Liew H, Mein S, Tessonnier T, Abdollahi A, Debus J, Dokic I, Mairani A. The Impact of Sub-Millisecond Damage Fixation Kinetics on the In Vitro Sparing Effect at Ultra-High Dose Rate in UNIVERSE. International Journal of Molecular Sciences. 2022; 23(6):2954. https://doi.org/10.3390/ijms23062954
Chicago/Turabian StyleLiew, Hans, Stewart Mein, Thomas Tessonnier, Amir Abdollahi, Jürgen Debus, Ivana Dokic, and Andrea Mairani. 2022. "The Impact of Sub-Millisecond Damage Fixation Kinetics on the In Vitro Sparing Effect at Ultra-High Dose Rate in UNIVERSE" International Journal of Molecular Sciences 23, no. 6: 2954. https://doi.org/10.3390/ijms23062954