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Article

CT and MRI Imaging of Theranostic Bimodal Fe3O4@Au NanoParticles in Tumor Bearing Mice

by
Alexey A. Lipengolts
1,
Yulia A. Finogenova
1,
Vsevolod A. Skribitsky
1,
Kristina E. Shpakova
1,
Adi Anaki
2,3,
Menachem Motiei
2,3,
Alevtina S. Semkina
4,
Maxim A. Abakumov
4,
Anna V. Smirnova
1,
Elena Y. Grigorieva
1 and
Rachela Popovtzer
2,3,*
1
N.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia
2
The Alexander Kofkin Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel
3
Bar-Ilan Institute for Nanotechnology and Advanced Materials (BINA), Bar-Ilan University, Ramat Gan 5290002, Israel
4
Department of Medical Nanobiotechnoilogy, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(1), 70; https://doi.org/10.3390/ijms24010070
Submission received: 24 November 2022 / Revised: 13 December 2022 / Accepted: 16 December 2022 / Published: 21 December 2022
(This article belongs to the Special Issue Anticancer Therapy)
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Abstract

Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging of nanoparticles in a tumor and surrounding normal tissues is crucial both for diagnostics and for nanoparticle application as radiosensitizers. The Fe3O4 core was introduced into gold nanoparticles to form a core/shell structure suitable for MRI imaging. The aim of this study was to assess the in vivo bimodal CT and MRI enhancement ability of novel core/shell Fe3O4@Au theranostic nanoparticles. Core/shell Fe3O4@Au nanoparticles were synthesized and coated with PEG and glucose. C57Bl/6 mice bearing Ca755 mammary adenocarcinoma tumors received intravenous injections of the nanoparticles. CT and MRI were performed at several timepoints between 5 and 102 min, and on day 17 post-injection. Core/shell Fe3O4@Au nanoparticles provided significant enhancement of the tumor and tumor blood vessels. Nanoparticles also accumulated in the liver and spleen and were retained in these organs for 17 days. Mice did not show any signs of toxicity over the study duration. These results indicate that theranostic bimodal Fe3O4@Au nanoparticles are non-toxic and serve as effective contrast agents both for CT and MRI diagnostics. These nanoparticles have potential for future biomedical applications in cancer diagnostics and beyond.
Keywords: nanoparticles; CT; MRI; contrast agent; tumor nanoparticles; CT; MRI; contrast agent; tumor

Share and Cite

MDPI and ACS Style

Lipengolts, A.A.; Finogenova, Y.A.; Skribitsky, V.A.; Shpakova, K.E.; Anaki, A.; Motiei, M.; Semkina, A.S.; Abakumov, M.A.; Smirnova, A.V.; Grigorieva, E.Y.; et al. CT and MRI Imaging of Theranostic Bimodal Fe3O4@Au NanoParticles in Tumor Bearing Mice. Int. J. Mol. Sci. 2023, 24, 70. https://doi.org/10.3390/ijms24010070

AMA Style

Lipengolts AA, Finogenova YA, Skribitsky VA, Shpakova KE, Anaki A, Motiei M, Semkina AS, Abakumov MA, Smirnova AV, Grigorieva EY, et al. CT and MRI Imaging of Theranostic Bimodal Fe3O4@Au NanoParticles in Tumor Bearing Mice. International Journal of Molecular Sciences. 2023; 24(1):70. https://doi.org/10.3390/ijms24010070

Chicago/Turabian Style

Lipengolts, Alexey A., Yulia A. Finogenova, Vsevolod A. Skribitsky, Kristina E. Shpakova, Adi Anaki, Menachem Motiei, Alevtina S. Semkina, Maxim A. Abakumov, Anna V. Smirnova, Elena Y. Grigorieva, and et al. 2023. "CT and MRI Imaging of Theranostic Bimodal Fe3O4@Au NanoParticles in Tumor Bearing Mice" International Journal of Molecular Sciences 24, no. 1: 70. https://doi.org/10.3390/ijms24010070

APA Style

Lipengolts, A. A., Finogenova, Y. A., Skribitsky, V. A., Shpakova, K. E., Anaki, A., Motiei, M., Semkina, A. S., Abakumov, M. A., Smirnova, A. V., Grigorieva, E. Y., & Popovtzer, R. (2023). CT and MRI Imaging of Theranostic Bimodal Fe3O4@Au NanoParticles in Tumor Bearing Mice. International Journal of Molecular Sciences, 24(1), 70. https://doi.org/10.3390/ijms24010070

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