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Article

Revealing the Role of Alternariol in the Local Steroidogenesis in Human Prostate Normal and Cancer Cells

by
Kinga Anna Urbanek
1,
Karolina Kowalska
1,
Dominika Ewa Habrowska-Górczyńska
1,
Marta Justyna Kozieł
1,2,
Kamila Domińska
3 and
Agnieszka Wanda Piastowska-Ciesielska
1,2,*
1
Medical University of Lodz, Department of Cell Cultures and Genomic Analysis, 90-752 Lodz, Poland
2
Medical University of Lodz, BRaIn Laboratories, 92-216 Lodz, Poland
3
Medical University of Lodz, Department of Comparative Endocrinology, Zeligowskiego 7/9, 90-752 Lodz, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(11), 9513; https://doi.org/10.3390/ijms24119513
Submission received: 28 April 2023 / Revised: 24 May 2023 / Accepted: 27 May 2023 / Published: 30 May 2023
(This article belongs to the Special Issue Expression of Signaling Genes in Cancer and Other Pathologies)
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Abstract

The mycotoxin alternariol (AOH) can be found in food products infected by Alternaria spp. and is considered an endocrine-disruptive mycotoxin. The main mechanism of AOH toxicity is associated with DNA damage and modulation of the inflammation process. Still, AOH is considered as one of the emerging mycotoxins. In this study, we have evaluated how AOH might affect the local steroidogenesis process in the prostate, in both normal and cancer cells. We have found that AOH itself modulates the cell cycle, inflammation, and apoptosis, rather than the steroidogenesis process in prostate cancer cells; however, in the presence of another steroidogenic agent, the influence on steroidogenesis is significant. Therefore, this is the first study to report the effect of AOH on local steroidogenesis in normal and prostate cancer cells. We postulate that AOH might modulate the release of the steroid hormones and expression of the key components by interfering with the steroidogenic pathway and might be considered a steroidogenesis-altering agent.
Keywords: alternariol; steroidogenesis; mycotoxin; carcinogenesis; dehydroepiandrosterone alternariol; steroidogenesis; mycotoxin; carcinogenesis; dehydroepiandrosterone

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MDPI and ACS Style

Urbanek, K.A.; Kowalska, K.; Habrowska-Górczyńska, D.E.; Kozieł, M.J.; Domińska, K.; Piastowska-Ciesielska, A.W. Revealing the Role of Alternariol in the Local Steroidogenesis in Human Prostate Normal and Cancer Cells. Int. J. Mol. Sci. 2023, 24, 9513. https://doi.org/10.3390/ijms24119513

AMA Style

Urbanek KA, Kowalska K, Habrowska-Górczyńska DE, Kozieł MJ, Domińska K, Piastowska-Ciesielska AW. Revealing the Role of Alternariol in the Local Steroidogenesis in Human Prostate Normal and Cancer Cells. International Journal of Molecular Sciences. 2023; 24(11):9513. https://doi.org/10.3390/ijms24119513

Chicago/Turabian Style

Urbanek, Kinga Anna, Karolina Kowalska, Dominika Ewa Habrowska-Górczyńska, Marta Justyna Kozieł, Kamila Domińska, and Agnieszka Wanda Piastowska-Ciesielska. 2023. "Revealing the Role of Alternariol in the Local Steroidogenesis in Human Prostate Normal and Cancer Cells" International Journal of Molecular Sciences 24, no. 11: 9513. https://doi.org/10.3390/ijms24119513

APA Style

Urbanek, K. A., Kowalska, K., Habrowska-Górczyńska, D. E., Kozieł, M. J., Domińska, K., & Piastowska-Ciesielska, A. W. (2023). Revealing the Role of Alternariol in the Local Steroidogenesis in Human Prostate Normal and Cancer Cells. International Journal of Molecular Sciences, 24(11), 9513. https://doi.org/10.3390/ijms24119513

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