Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease

Ekeuku, Sophia Ogechi; Mohd Murshid, Nuraqila; Shukri, Siti Nursyazwani; Mohd Sahardi, Nur Fatin Nabilah; Makpol, Suzana

doi:10.3390/ijms241512372

Open AccessReview

Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease

by

Sophia Ogechi Ekeuku

,

Nuraqila Mohd Murshid

,

Siti Nursyazwani Shukri

,

Nur Fatin Nabilah Mohd Sahardi

and

Suzana Makpol

^*

Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Level 17, Preclinical Building, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2023, 24(15), 12372; https://doi.org/10.3390/ijms241512372

Submission received: 3 June 2023 / Revised: 8 July 2023 / Accepted: 17 July 2023 / Published: 3 August 2023

(This article belongs to the Special Issue Natural Polyphenols and Brain Health)

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Abstract

Research into ageing is focused on understanding why some people can maintain cognitive ability and others lose autonomy, affecting their quality of life. Studies have revealed that age-related neurodegenerative disorders like Alzheimer’s disease (AD) are now major causes of death among the elderly, surpassing malignancy. This review examines the effects of vitamin E on transcriptomic changes in ageing and neurodegenerative diseases, using AD as an example, and how different transcriptome profiling techniques can shape the results. Despite mixed results from transcriptomic studies on AD patients’ brains, we think advanced technologies could offer a more detailed and accurate tool for such analysis. Research has also demonstrated the role of antioxidant modifiers in preventing AD. This review will explore the key findings regarding AD and its modulation by vitamin E, emphasizing the shift in its epidemiology during the ageing process.

Keywords: vitamin E; transcriptomics changes; Alzheimer’s disease

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MDPI and ACS Style

Ekeuku, S.O.; Mohd Murshid, N.; Shukri, S.N.; Mohd Sahardi, N.F.N.; Makpol, S. Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease. Int. J. Mol. Sci. 2023, 24, 12372. https://doi.org/10.3390/ijms241512372

AMA Style

Ekeuku SO, Mohd Murshid N, Shukri SN, Mohd Sahardi NFN, Makpol S. Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease. International Journal of Molecular Sciences. 2023; 24(15):12372. https://doi.org/10.3390/ijms241512372

Chicago/Turabian Style

Ekeuku, Sophia Ogechi, Nuraqila Mohd Murshid, Siti Nursyazwani Shukri, Nur Fatin Nabilah Mohd Sahardi, and Suzana Makpol. 2023. "Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease" International Journal of Molecular Sciences 24, no. 15: 12372. https://doi.org/10.3390/ijms241512372

APA Style

Ekeuku, S. O., Mohd Murshid, N., Shukri, S. N., Mohd Sahardi, N. F. N., & Makpol, S. (2023). Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease. International Journal of Molecular Sciences, 24(15), 12372. https://doi.org/10.3390/ijms241512372

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease

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