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Natural Polyphenols and Brain Health
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Natural Polyphenols and Brain Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 2541

Special Issue Editor

Dr. Leonel E. Rojo

E-Mail Website
Guest Editor
Departamento de Biología, University of Santiago, Santiago 9170002, Chile
Interests: natural products; neurodegenerative diseases; neurobiology; biomedicine; pharmaology; metabolism

Special Issue Information

Dear Colleagues,

Polyphenolic compounds are a general term for a group of chemical substances containing multiple phenolic hydroxyl groups, which are widely distributed in a variety of natural plants or fruits. In the chemical structure of polyphenols, the easily oxidized ortho-phenolic hydroxyl endows polyphenols with strong antioxidant properties and the ability to scavenge free radicals. Therefore, it exhibits a wide range of biological activities such as anti-oxidation, anti-cardiovascular and cerebrovascular diseases, anti-tumor and anti-virus. Many studies have shown that polyphenolic compounds can exert anti-cardiovascular and cerebrovascular diseases through various mechanisms. Such as salvianolic acid has various physiological activities anti-thrombotic, anti-atherosclerosis and anti-cerebral ischemia. 

This Special Issue entitled “Natural Polyphenols and Brain Health” aim to collect review paper or an original research paper focus on this topic.

Dr. Leonel E. Rojo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • brain diseases
  • antioxidant
  • molecular mechanism
  • anti-cardiovascular

Published Papers (2 papers)

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Research

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14 pages, 1430 KiB  
Article
Temperature-Dependent Olive Pomace Extraction for Obtaining Bioactive Compounds Preventing the Death of Murine Cortical Neurons
by Alessandro Alberto Casazza, Michela Capraro, Marco Pedrazzi, Giulia D’Agostino, Franco Onofri, Antonella Marte, Roberta De Tullio, Patrizia Perego and Monica Averna
Int. J. Mol. Sci. 2024, 25(2), 907; https://doi.org/10.3390/ijms25020907 - 11 Jan 2024
Viewed by 764
Abstract
High-pressure and temperature extraction (HPTE) can effectively recover bioactive compounds from olive pomace (OP). HPTE extract obtained by extracting OP with ethanol and water (50:50 v/v) at 180 °C for 90 min demonstrated a pronounced ability to preserve intracellular calcium [...] Read more.
High-pressure and temperature extraction (HPTE) can effectively recover bioactive compounds from olive pomace (OP). HPTE extract obtained by extracting OP with ethanol and water (50:50 v/v) at 180 °C for 90 min demonstrated a pronounced ability to preserve intracellular calcium homeostasis, shielding neurons from the harmful effects induced by N-methyl-d-aspartate (NMDA) receptor (NMDAR) overactivation, such as aberrant calpain activation. In this study, the extraction temperature was changed from 37 to 180 °C, and the extracts were evaluated for their antioxidant potency and ability to preserve crucial intracellular Ca2+-homeostasis necessary for neuronal survival. Additionally, to verify the temperature-induced activity of the extract, further extractions on the exhausted olive pomace were conducted, aiming to identify variations in the quality and quantity of extracted phenolic molecules through HPLC analysis. The results revealed a significant increase in bioactive compounds as a function of temperature variation, reaching 6.31 ± 0.09 mgCAE/mL extract for the extraction performed at 180 °C. Subsequent extraction of the exhausted residues yielded extracts that remained active in preventing calcium-induced cell death. Moreover, despite increased antiradical power, extracts re-treated at 180 °C did not display cell protection activity. Our results indicate that the molecules able to maintain physiological Ca2+-homeostasis in murine cortical neurons in conditions of cytotoxic stimulation of NMDAR are wholly recovered from olive pomace only following extraction performed at 180 °C. Full article
(This article belongs to the Special Issue Natural Polyphenols and Brain Health)
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Review

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14 pages, 1125 KiB  
Review
Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease
by Sophia Ogechi Ekeuku, Nuraqila Mohd Murshid, Siti Nursyazwani Shukri, Nur Fatin Nabilah Mohd Sahardi and Suzana Makpol
Int. J. Mol. Sci. 2023, 24(15), 12372; https://doi.org/10.3390/ijms241512372 - 3 Aug 2023
Viewed by 1480
Abstract
Research into ageing is focused on understanding why some people can maintain cognitive ability and others lose autonomy, affecting their quality of life. Studies have revealed that age-related neurodegenerative disorders like Alzheimer’s disease (AD) are now major causes of death among the elderly, [...] Read more.
Research into ageing is focused on understanding why some people can maintain cognitive ability and others lose autonomy, affecting their quality of life. Studies have revealed that age-related neurodegenerative disorders like Alzheimer’s disease (AD) are now major causes of death among the elderly, surpassing malignancy. This review examines the effects of vitamin E on transcriptomic changes in ageing and neurodegenerative diseases, using AD as an example, and how different transcriptome profiling techniques can shape the results. Despite mixed results from transcriptomic studies on AD patients’ brains, we think advanced technologies could offer a more detailed and accurate tool for such analysis. Research has also demonstrated the role of antioxidant modifiers in preventing AD. This review will explore the key findings regarding AD and its modulation by vitamin E, emphasizing the shift in its epidemiology during the ageing process. Full article
(This article belongs to the Special Issue Natural Polyphenols and Brain Health)
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