Extra Virgin Olive Oil and Metabolic Diseases

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The authors described that EVOO presents a multitude of healthful properties and acts as a key parameter of clinical nutrition. The authors review the positive effects of EVOO, but their discussion is insufficient to warrant publication as a review. Adding answers to the questions below will help ensure the importance of this review.

1. The authors should describe and illustrate the mechanism by which EVOO exerts its positive effects.

1-1) Does EVOO exert its physiological effects via receptors?

1-2) Is EVOO taken up into cells and functions as a second messenger?

1-3) Does EVOO enhance or inhibit intracellular signaling mediated by some ligand-induced receptors?

1-4) Does EVOO incorporate into cell membranes and affect cell function?

1-5）Does EVOO bind to nutrients and affect their absorption from the intestinal tract or metabolism in the blood?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Comments and Suggestions for Authors

This review article describes EVOO's beneficial health effects, including anti-diabetic, hypolipidemic, anti-hypertensive, and anti-obesity. The review is of great biological and medical relevance. It is well-organized and well-referenced, including key proposed mechanisms for EVOO-mediated protective vascular actions. 

Minor comments: Table 1 needs to be improved. Specifically, please add the quantity of each EVOO component at least in % i.e. fatty acid composition, minor components, sterols, polyphenols, and flavonoids, among others.

Comments on the Quality of English Language

Minor editing is required.

Author Response

Please see the attachment.

Author Response File: Author Response.docx