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Review
Peer-Review Record

Therapeutic Transplantation of Human Central Nervous System Organoids for Neural Reconstruction

Int. J. Mol. Sci. 2024, 25(15), 8540; https://doi.org/10.3390/ijms25158540
by Sung Jun Hong 1,2,†, Minsung Bock 3,†, Songzi Zhang 3, Seong Bae An 3 and Inbo Han 3,*
Reviewer 1:
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2024, 25(15), 8540; https://doi.org/10.3390/ijms25158540
Submission received: 24 June 2024 / Revised: 3 August 2024 / Accepted: 3 August 2024 / Published: 5 August 2024
(This article belongs to the Special Issue Molecular Research in Spinal Cord Injury)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

In this review, the authors highlight the fact that many treatments for damage to the central nervous system are not available today.  Many of these damages can lead to irreversible neurological deficiencies. The review highlights the potential role of organoids in direct repair at injury sites. In particular, the authors critically analyze and evaluate preclinical transplantation results, advantages and disadvantages. The use of organoids could be used in the future to study the phenomenon of neuro-regeneration.  

The review is well written and clear; the topic is of great interest to the scientific community, especially of great interest for the study of neurodegenerative diseases.

 

The figures are clear and very understandable. The literature references are complete and relevant.

 

Section 3.3 Parkinson's Disease lacks a brief reference to the hallmarks of the disease: the role of synuclein (aggregation) and neuromelanin.

 

The review deserves publication after the suggested addition of a small reference to the hallmarks of Parkinson's disease

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

Please see attached document

Comments for author File: Comments.pdf

Comments on the Quality of English Language

Minor editing of English language required

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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