Heterogeneous IL-9 Production by Circulating Skin-Tropic and Extracutaneous Memory T Cells in Atopic Dermatitis Patients
Abstract
:1. Introduction
2. Results
2.1. In AD Patients, HDM-Induced CLA+/CLA− T-Cell IL-9 Levels Are Higher Than Th2, Th1, and Th17-Related Cytokines and Correlate with Plasma IgE
2.2. HDM-Induced IL-9 Secretion by Memory T Cells Requires the Contribution of Autologous Epidermal Cells and Depends on HLA-Mediated Presentation
2.3. AD Patients Producing HDM-Induced IL-9 in CLA+/CLA− Memory T Cells Present Higher Levels of HDM-Specific and Total IgE
2.4. SEB Induces Low IL-9 Production in CLA+ and CLA− Memory T Cells Compared to Other Proinflammatory Cytokines
3. Discussion
4. Materials and Methods
4.1. Patients and Biological Samples
4.2. Isolation of CLA+/− Memory T Cells and Epidermal Cell Suspension
4.3. Coculture of CLA+/− Memory T Cells with Epidermal Cells and Stimulation
4.4. Cytokine Quantification
4.5. Quantification of Total and Specific IgE against HDM, S. aureus, and SEB
4.6. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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García-Jiménez, I.; Sans-de San Nicolás, L.; Curto-Barredo, L.; Bertolín-Colilla, M.; Sensada-López, E.; Figueras-Nart, I.; Bonfill-Ortí, M.; Guilabert-Vidal, A.; Ryzhkova, A.; Ferran, M.; et al. Heterogeneous IL-9 Production by Circulating Skin-Tropic and Extracutaneous Memory T Cells in Atopic Dermatitis Patients. Int. J. Mol. Sci. 2024, 25, 8569. https://doi.org/10.3390/ijms25168569
García-Jiménez I, Sans-de San Nicolás L, Curto-Barredo L, Bertolín-Colilla M, Sensada-López E, Figueras-Nart I, Bonfill-Ortí M, Guilabert-Vidal A, Ryzhkova A, Ferran M, et al. Heterogeneous IL-9 Production by Circulating Skin-Tropic and Extracutaneous Memory T Cells in Atopic Dermatitis Patients. International Journal of Molecular Sciences. 2024; 25(16):8569. https://doi.org/10.3390/ijms25168569
Chicago/Turabian StyleGarcía-Jiménez, Irene, Lídia Sans-de San Nicolás, Laia Curto-Barredo, Marta Bertolín-Colilla, Eloi Sensada-López, Ignasi Figueras-Nart, Montserrat Bonfill-Ortí, Antonio Guilabert-Vidal, Anna Ryzhkova, Marta Ferran, and et al. 2024. "Heterogeneous IL-9 Production by Circulating Skin-Tropic and Extracutaneous Memory T Cells in Atopic Dermatitis Patients" International Journal of Molecular Sciences 25, no. 16: 8569. https://doi.org/10.3390/ijms25168569