Automatic Detection of the EEG Spike–Wave Patterns in Epilepsy: Evaluation of the Effects of Transcranial Current Stimulation Therapy
Abstract
:1. Introduction
2. Results
2.1. The Impact of Choice of the Reference Electrode on SW Patterns Identification
2.2. The Performance of SW Patterns Classification
2.3. Impact of Standardization on Classification Performance
2.4. SW Patterns Similarity Testing
2.5. Impact of Single Features on Classification Performance
2.6. Impact of the ctDCS on the Morphology of SW Patterns
3. Discussion
4. Materials and Methods
4.1. Patient Recruitment
4.2. ctDCS Treatment
4.3. EEG Recording
4.4. Automatic Detection of SW Patterns
4.4.1. EEG Preprocessing
4.4.2. Identification of Potential SW Patterns
4.4.3. Features of SW Patterns
4.4.4. Selection of SW Patterns
4.5. Similarity Index
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
References
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Subject | Condition | Similarity Index | Standardization | TP | FP | TN | FN | Sensitivity | Selectivity | Specificity |
---|---|---|---|---|---|---|---|---|---|---|
P1 | PRE STIM POST STIM | NO NO | NO NO | 139 99 | 13 12 | 16033 63778 | 15 11 | 0.91 0.89 | 0.90 0.90 | 1.00 1.00 |
PRE STIM POST STIM | YES YES | NO NO | 58 62 | 94 49 | 15952 63741 | 96 48 | 0.38 0.56 | 0.38 0.56 | 0.99 1.00 | |
PRE STIM POST STIM | NO NO | YES YES | 145 104 | 62 41 | 15984 63749 | 9 6 | 0.70 0.72 | 0.94 0.95 | 1.00 1.00 | |
PRE STIM POST STIM | YES YES | YES YES | 114 110 | 93 35 | 15953 63755 | 40 0 | 0.55 0.76 | 0.74 1.00 | 0.99 1.00 | |
P2 | - | NO | YES | 112 | 9 | 29868 | 11 | 0.93 | 0.91 | 1.00 |
YES | YES | 114 | 7 | 29870 | 9 | 0.94 | 0.93 | 1.00 |
Feature | PRE_STIM | POST_STIM | p-Value |
---|---|---|---|
f1 | 0.48±0.15 | 0.47±0.11 | p < 0.100 |
f2 | 4.63 ± 1.02 | 4.19 ± 1.08 | p < 0.010 |
f3 | 1.06 ± 0.24 | 0.80 ± 0.19 | p < 0.001 |
f4 | 1.14 ± 0.23 | 0.92 ± 0.19 | p < 0.001 |
f5 | 0.66 ± 0.13 | 0.59 ± 0.13 | p < 0.001 |
f6 | 1.24 ± 0.21 | 1.33 ± 0.23 | p < 0.040 |
f7 | 7.60 ± 1.45 | 7.20 ± 1.27 | p < 0.100 |
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Olejarczyk, E.; Sobieszek, A.; Assenza, G. Automatic Detection of the EEG Spike–Wave Patterns in Epilepsy: Evaluation of the Effects of Transcranial Current Stimulation Therapy. Int. J. Mol. Sci. 2024, 25, 9122. https://doi.org/10.3390/ijms25169122
Olejarczyk E, Sobieszek A, Assenza G. Automatic Detection of the EEG Spike–Wave Patterns in Epilepsy: Evaluation of the Effects of Transcranial Current Stimulation Therapy. International Journal of Molecular Sciences. 2024; 25(16):9122. https://doi.org/10.3390/ijms25169122
Chicago/Turabian StyleOlejarczyk, Elzbieta, Aleksander Sobieszek, and Giovanni Assenza. 2024. "Automatic Detection of the EEG Spike–Wave Patterns in Epilepsy: Evaluation of the Effects of Transcranial Current Stimulation Therapy" International Journal of Molecular Sciences 25, no. 16: 9122. https://doi.org/10.3390/ijms25169122