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Article
Peer-Review Record

Silver and Gold Complexes with NHC-Ligands Derived from Caffeine: Catalytic and Pharmacological Activity

Int. J. Mol. Sci. 2024, 25(5), 2599; https://doi.org/10.3390/ijms25052599
by Annaluisa Mariconda 1, Domenico Iacopetta 2, Marco Sirignano 3, Jessica Ceramella 2, Assunta D’Amato 3, Maria Marra 2, Michele Pellegrino 2, Maria Stefania Sinicropi 2,*, Stefano Aquaro 2,† and Pasquale Longo 3,†
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Int. J. Mol. Sci. 2024, 25(5), 2599; https://doi.org/10.3390/ijms25052599
Submission received: 6 February 2024 / Revised: 19 February 2024 / Accepted: 21 February 2024 / Published: 23 February 2024

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The revised manuscript has addressed all issues raised by previous reviewers. Therefore, I would like to recommend this manuscript to publish as its current form in IJMS. 

Author Response

Please, see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

The authors addressed my previous concerns in their resubmitted manuscript. Accordingly, I feel that the manuscript might be suitable for publication in the current form.

Author Response

Please, see the attachment

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

The authors have improved their previous submission on the biological activity and catalytic applications of Au and Ag complexes of three caffeine derivatives.

Most of my previous concerns have been addressed, but some minor revisions should be considered before publication:

- Hydrolysis tests meant to determine the long term stability of the metal drugs should be performed in physiological solution (in the presence of chloride ions);

- Line 224-226 should be deleted coming from the template instructions.

Author Response

Please, see the attachment

Author Response File: Author Response.pdf

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