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Article

Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt

by
Shavkat I. Salikhov
1,
Egor V. Musin
2,
Aleksandr L. Kim
2,
Yulia I. Oshchepkova
1 and
Sergey A. Tikhonenko
2,*
1
Institute of Bioorganic Chemistry Named after A.Sadykov Academy of Sciences of the Republic of Uzbekistan, M. Ulugbek Str., 83, Tashkent 100125, Uzbekistan
2
Institute of Theoretical and Experimental Biophysics Russian Academy of Science, Institutskaya St., 3, 142290 Puschino, Moscow Region, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(5), 2652; https://doi.org/10.3390/ijms25052652
Submission received: 23 January 2024 / Revised: 21 February 2024 / Accepted: 22 February 2024 / Published: 24 February 2024
(This article belongs to the Special Issue Polymeric Materials for Biomedical Applications, Drug and Gene Delivery)
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Abstract

Allapinin has antiarrhythmic activity and can be used to prevent and treat various supraventricular and ventricular arrhythmias. Nevertheless, it is highly toxic and has a number of side effects associated with non-specific accumulation in various tissues. The complex of this substance with the monoammonium salt of glycyrrhizic acid (Al:MASGA) has less toxicity and improved antiarrhythmic activity. However, the encapsulation of Al:MASGA in polyelectrolyte microcapsules (PMC) for prolonged release will reduce the residual adverse effects of this drug. In this work, the possibility of encapsulating the allapinin–MASGA complex in polyelectrolyte microcapsules based on polyallylamine and polystyrene sulfonate was investigated. The encapsulation methods of the allapinin–MASGA in polyelectrolyte microcapsules by adsorption and coprecipitation were compared. It was found that the coprecipitation method did not result in the encapsulation of Al:MASGA. The sorption method facilitated the encapsulation of up to 80% of the original substance content in solution in PMC. The release of the encapsulated substance was further investigated, and it was shown that the release of the encapsulated Al:MASGA was independent of the substance content in the capsules, but at pH 5, a two-fold decrease in the rate of drug release was observed.
Keywords: polyelectrolyte microcapsules; allapinin; encapsulation; drug delivery; prolonged release polyelectrolyte microcapsules; allapinin; encapsulation; drug delivery; prolonged release

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MDPI and ACS Style

Salikhov, S.I.; Musin, E.V.; Kim, A.L.; Oshchepkova, Y.I.; Tikhonenko, S.A. Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt. Int. J. Mol. Sci. 2024, 25, 2652. https://doi.org/10.3390/ijms25052652

AMA Style

Salikhov SI, Musin EV, Kim AL, Oshchepkova YI, Tikhonenko SA. Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt. International Journal of Molecular Sciences. 2024; 25(5):2652. https://doi.org/10.3390/ijms25052652

Chicago/Turabian Style

Salikhov, Shavkat I., Egor V. Musin, Aleksandr L. Kim, Yulia I. Oshchepkova, and Sergey A. Tikhonenko. 2024. "Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt" International Journal of Molecular Sciences 25, no. 5: 2652. https://doi.org/10.3390/ijms25052652

APA Style

Salikhov, S. I., Musin, E. V., Kim, A. L., Oshchepkova, Y. I., & Tikhonenko, S. A. (2024). Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt. International Journal of Molecular Sciences, 25(5), 2652. https://doi.org/10.3390/ijms25052652

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