1
Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada
2
Department of Chemistry, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada
3
Ophthalmology Department, Faculty of Medecine, Université Laval, Québec City, QC G1V 0A6, Canada
4
Research Center of CHU de Quebec, (Centre Hospitalier Universitaire)-Université Laval, Québec City, QC G1V 0A6, Canada
5
Centre de Recherche du Centre Hospitalier Universitaire de Québec (CR-CHUQ), Axe Médecine Régénératrice, Québec City, QC G1L 3L5, Canada
6
Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, Québec City, QC G1V 0A6, Canada
7
Département de Génie des Mines, de la Métallurgie et des Matériaux, Université Laval, Québec City, QC G1V 0A6, Canada
†
These authors contributed equally to this work.
‡
Current address: Laval University; Adrien-Pouliot Build. Room 2110; Department of Electrical and Computer Engineering, 1065, Médecine Av., Québec, QC G1V 0A6, Canada.
Abstract
In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT) sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration
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In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT) sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle measurement or drug delivery or both measurement and drug delivery simultaneously. The system is composed of three fully independent modules: three-channel peristaltic micropumping system, a three-channel potentiostat and a multi-unit microfluidic system composed of pseudo-Y and cross-shape channels containing a miniature electrode array. The system was wirelessly controlled by a computer interface. The system is compact, with all the microfluidic and sensing components packaged in a 5 cm × 4 cm × 4 cm box. Applied to serotonin, a linear calibration curve down to 0.125 mM, with a limit of detection of 31
M was collected at unfunctionalized electrodes. Added sensitivity and selectivity was achieved by incorporating functionalized electrodes for dopamine sensing. Electrode functionalization was achieved with gold nanoparticles and using DNA and o-phenylene diamine polymer. The as-configured platform is demonstrated as a central component toward an “intelligent” drug delivery system based on a feedback loop to monitor drug delivery.
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