Genetic Variants Associated with Body Mass Index Changes in Korean Adults: The Anseong and Ansan Cohorts of the Korean Genome and Epidemiology Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Statistical Analysis
2.3. Ethics Statement
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | Mean | Standard Deviation | Max | Min | N |
---|---|---|---|---|---|
BMI | 24.607 | 3.032 | 40.259 | 12.535 | 21,518 |
Age | 53.765 | 8.401 | 75 | 40 | 21,518 |
Sex | 1.523 | 0.499 | 2 | 1 | 21,518 |
24.607 | 0.041 | 24.673 | 24.505 | 21,518 | |
0.000 | 3.032 | 15.750 | −11.994 | 21,518 |
Variable | Male | Female | Difference (t-Value) |
---|---|---|---|
Age | 53.329 | 54.164 | −0.834 (−8.18) *** |
BMI | 24.430 | 24.768 | −0.338 (−7.28) *** |
24.609 | 24.605 | 0.004 (7.28) *** | |
−0.179 | 0.163 | −0.342 (−8.27) *** | |
N | 10,269 | 11,249 | Sum = 21,518 |
SNP Id | Gene | Mutations | Class | p-Value | |||
---|---|---|---|---|---|---|---|
All | Male | Female | |||||
rs7105363 | GRIK4, LOC105369532 | intron variant | Silent | protective | * 0.000 | 0.033 | * 0.005 |
rs8027765 | AEN | Missense | N140D | protective | * 0.000 | 0.010 | * 0.006 |
rs2373011 | ANKS1B | intron variant | Silent | protective | * 0.000 | 0.011 | * 0.005 |
rs2229165 | CSF1 | intron variant, missense | Silent, G438R | protective | * 0.001 | 0.038 | * 0.008 |
rs9935059 | EEF2K | missense, transcript variant | H23R | risk | * 0.000 | 0.014 | * 0.006 |
rs34670941 | FRAS1 | Missense | V3626A | risk | * 0.000 | 0.021 | * 0.007 |
rs4691380 | PDGFC | intron variant | Silent | risk | * 0.000 | * 0.001 | * 0.003 |
rs4982766 | THTPA, ZFHX2 | intron variant, missense | Silent, V1545A | risk | * 0.001 | 0.036 | * 0.008 |
rs2276064 | TREH | Missense | R486W | risk | * 0.001 | * 0.004 | 0.044 |
Term | Count | % | p-Value | Genes |
---|---|---|---|---|
Cluster 1 | ||||
Null | 4 | 57.1 | 0.006 | TNFRSF1A, CSF1, TIRAP, ITGAM |
Tuberculosis | 3 | 42.9 | 0.009 | TNFRSF1A, TIRAP, ITGAM |
Type 2 Diabetes, edema, rosiglitazone | 5 | 71.4 | 0.009 | TNFRSF1A, CSF1, TIRAP, CASP1, ITGAM |
Pharmacogenomic | 5 | 71.4 | 0.020 | TNFRSF1A, CSF1, TIRAP, CASP2, ITGAM |
Unknown | 4 | 57.1 | 0.029 | TNFRSF1A, CSF1, TIRAP, ITGAM |
Immune | 4 | 57.1 | 0.139 | TNFRSF1A, CSF1, TIRAP, ITGAM |
Cluster 2 | ||||
Acquired immunodeficiency syndrome | 3 | 75.0 | 0.014 | MUT, ALDH1B, IREB2 |
Cardiovascular | 4 | 100.0 | 0.036 | ALDH1A2, MUT, ALDH1B, IREB2 |
Infection | 3 | 75.0 | 0.074 | MUT, ALDH1B, IREB2 |
Cluster 3 | ||||
Splice variant | 3 | 75.0 | 0.150 | SH3GL3, FRAS1, CLTCL1 |
Membrane | 3 | 75.0 | 0.301 | SH3GL3, FRAS1, CLTCL2 |
Phosphoprotein | 3 | 75.0 | 0.353 | SH3GL3, FRAS1, CLTCL3 |
Alternative splicing | 3 | 75.0 | 0.522 | SH3GL3, FRAS1, CLTCL4 |
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Lee, S.-I.; Kim, S.-K.; Kang, S.-W. Genetic Variants Associated with Body Mass Index Changes in Korean Adults: The Anseong and Ansan Cohorts of the Korean Genome and Epidemiology Study. Curr. Issues Mol. Biol. 2024, 46, 9074-9081. https://doi.org/10.3390/cimb46080536
Lee S-I, Kim S-K, Kang S-W. Genetic Variants Associated with Body Mass Index Changes in Korean Adults: The Anseong and Ansan Cohorts of the Korean Genome and Epidemiology Study. Current Issues in Molecular Biology. 2024; 46(8):9074-9081. https://doi.org/10.3390/cimb46080536
Chicago/Turabian StyleLee, Sang-Im, Su-Kang Kim, and Sang-Wook Kang. 2024. "Genetic Variants Associated with Body Mass Index Changes in Korean Adults: The Anseong and Ansan Cohorts of the Korean Genome and Epidemiology Study" Current Issues in Molecular Biology 46, no. 8: 9074-9081. https://doi.org/10.3390/cimb46080536