- Abstract
The Influence of CYP2C9 and VKORC1 Gene Polymorphisms on Optimal Warfarin Doses After Heart Valve Replacement
- Vacis Tatarūnas,
- Vaiva Lesauskaitė,
- Audronė Veikutienė,
- Povilas Jakuška and
- Rimantas Benetis
A clinical effect of warfarin depends on highly polymorphic drug-metabolizing (CYP2C9) and drug-target (VKORC1) enzymes. The objective of this study was to investigate the impact of CYP2C9*2, CYP2C9*3, and VKORC1 (G-1639A) polymorphisms on the variab...

