Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients Selection and Fetal Growing Assessment
2.2. Sample Collection, Initial Processing and Storage
2.3. Determination of BDNF in Umbilical Vein by ELISA Methodology
2.4. Statistical Analysys
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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GROUP A AGA N = 91 | GROUP B FGR N = 39 | p | |
---|---|---|---|
Maternal age (years) M (IQR) | 32 (7) | 34 (5) | NS |
Gestational age (weeks) M (IQR) | 38 (4) | 35 (5) | <0.001 |
Fetal sex (female) n (%) | 49 (54) | 15 (38) | NS |
MgSO4 n (%) | 0 | 9 (23) | <0.001 |
Lung maturation n (%) | 1 (1) | 16 (41) | <0.001 |
Cesarean section n (%) | 11 (12) | 25 (64) | <0.001 |
UtA PI > p95 n (%) | N/A | 18 (46) | N/A |
Preeclampsia n (%) | 1 (1) | 6 (15) | 0.005 |
Birth weight (g) M (IQR) | 3290 (650) | 1750 (870) | <0.001 |
Weight centile M (IQR) | 65 (45) | 0 (1) | <0.001 |
pH AU M (IQR) | 7.29 (0.11) | 7.26 (0.09) | NS |
Cord blood leukocytes (number/uL) M (IQR) | 15,600 (6500) | 12,700 (7500) | NS |
Neonatal care admission n (%) | 6 (6.6) | 25 (64) | <0.001 |
Intraventricular hemorrhage n (%) | 0 | 4 (10) | 0.007 |
BDNF (pg/mL) M (IQR) | 6980 (3735) | 4838 (4724) | 0.001 |
AGA N = 91 | FGR with MCA PI < 5th Exclusively N = 16 | p | |
---|---|---|---|
Maternal age (years) M (SD) | 32 (28–35) | 34 (31–35) | NS |
Gestational age (weeks) M (IQR) | 38 (36–40) | 36 (35–38) | 0.027 |
Fetal sex (female) n (%) | 49 (54) | 9 (56) | NS |
MgSO4 n (%) | 0 | 3 (19) | 0.003 |
Lung maturation n (%) | 1 (1) | 3 (19) | 0.01 |
Cesarean section n (%) | 11 (12) | 10 (63) | <0.001 |
UtA PI > p95 n (%) | N/A | 4 (25) | N/A |
Preeclampsia n (%) | 1 (1.3) | 4 (25) | NS |
Birth weight (g) m (SD) | 3302 (442) | 2069 (412) | <0.001 |
Weight centile M (IQR) | 65 (43–88) | 1 (1–3) | <0.001 |
pH AU M (IQR) | 7.29 (0.11) | 7.27 (0.08) | NS |
Cord blood leukocytes (number/uL) M (IQR) | 15,600 (6500) | 14,700 (7225) | NS |
Neonatal care admission n (%) | 6 (6.6) | 6 (37.5) | 0.002 |
Intraventricular hemorrhage n (%) | 0 | 0 | NS |
BDNF (pg/mL) m (SD) | 6980 (3735) | 6268 (3539) | NS |
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Pascual-Mancho, J.; Pintado-Recarte, P.; Morales-Camino, J.C.; Romero-Román, C.; Hernández-Martin, C.; Bravo, C.; Bujan, J.; Alvarez-Mon, M.; Ortega, M.A.; De León-Luis, J. Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses. Medicina 2022, 58, 178. https://doi.org/10.3390/medicina58020178
Pascual-Mancho J, Pintado-Recarte P, Morales-Camino JC, Romero-Román C, Hernández-Martin C, Bravo C, Bujan J, Alvarez-Mon M, Ortega MA, De León-Luis J. Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses. Medicina. 2022; 58(2):178. https://doi.org/10.3390/medicina58020178
Chicago/Turabian StylePascual-Mancho, Jara, Pilar Pintado-Recarte, Jorge C. Morales-Camino, Carlos Romero-Román, Concepción Hernández-Martin, Coral Bravo, Julia Bujan, Melchor Alvarez-Mon, Miguel A. Ortega, and Juan De León-Luis. 2022. "Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses" Medicina 58, no. 2: 178. https://doi.org/10.3390/medicina58020178