Novel Animal Model of Spontaneous Cerebral Petechial Hemorrhage Using Focused Ultrasound in Rats
, Kyoung-Tae Kim 3, Jeong-Hyun Hwang 3, Sungdae Na 5, Juyoung Park 6,* and Ki-Su Park 1,*
Round 1
Reviewer 1 Report
In this manuscript, Sang-Youl Yoon et al. implemented petechial hemorrhage using a novel technology, i.e., microbubble-assisted focused ultrasound (MB+FUS). This is an interesting paper. The article is well-conceived and well-executed. Microbubble-assisted focused-ultrasound (MB+FUS) is a particularly attractive noninvasive approach for permeabilizing the BBB. Satisfied with the significance of this study, the care in which the study was performed. The discussions presented are convincing and of extremely high interest.
Author Response
Thank you very much for your thoughtful review.
As suggested in the submitted article, the noninvasive animal model using microbubble-assisted focused-ultrasound is expected to be utilized in petechial hemorrhage research, and is expected to be helpful in the development of other brain hemorrhage models using this method in the future.
Reviewer 2 Report
Excellent paper and new model description.
Author Response
Thank you very much for your favorable reply.
As suggested in the submitted article, the noninvasive animal model using microbubble-assisted focused-ultrasound is expected to be utilized in petechial hemorrhage research, and is expected to be helpful in the development of other brain hemorrhage models using this method in the future.
