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Medicina, Volume 58, Issue 7

2022 July - 138 articles

Cover Story: Biomarkers are necessary for the diagnosis of Alzheimer’s disease (AD) and for advancing clinical trials for AD. The United States Food and Drug Administration (US FDA) has provided guidance for the definition of biomarkers and their contexts of use in drug development, qualitification, and implementation in clinical practice. The Common Alzheimer’s Disease Research Ontology (CADRO) defines known disease processes that comprise therapeutic targets for AD therapies and establishes a framework for AD treatment and biomarker development. Advances in biomarker development promise to provide key foundational information for progress toward new treatments for patients with AD. View this paper
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Articles (138)

  • Article
  • Open Access
3 Citations
3,623 Views
12 Pages

Orthopedic Surgeons’ Accuracy When Orienting an Acetabular Cup. A Comparison with Untrained Individuals

  • Jesús Moreta,
  • Óscar Gayoso,
  • Daniel Donaire-Hoyas,
  • Jorge Roces-García and ,
  • Jesús Gómez-Vallejo,
  • Esther Moya-Gómez,
  • David Raya-Roldán,
  • Alberto Albert-Ullibarri,
  • Fernando Marqués-López and
  • Jorge Albareda
  • + 5 authors+ 0 author

21 July 2022

Background and Objectives: Previous studies demonstrated a huge variability among surgeons when it comes to reproducing the position of an acetabular cup in total hip arthroplasty. Our main objective is to determine if orthopedic surgeons can replica...

(This article belongs to the Section Surgery)
  • Tutorial
  • Open Access
5 Citations
4,360 Views
18 Pages

Mathematically Directed Single-Cut Osteotomy

  • Stephen J. Wallace,
  • Joseph T. Patterson and
  • Sean E. Nork

21 July 2022

A mathematically directed osteotomy (MDO) is a surgical planning technique for correcting long bone deformities. Using a mathematically derived osteotomy plane, the single-cut correction simultaneously addresses angular deformity, axial malrotation,...

(This article belongs to the Special Issue Malunion of Fractures of the Lower Extremity)
  • Article
  • Open Access
19 Citations
4,723 Views
16 Pages

Uptake of COVID-19 Booster Dose among Saudi Arabian Population

  • Najim Z. Alshahrani,
  • Abdullah A. Alsabaani,
  • Iman Ridda,
  • Harunor Rashid and ,
  • Faris Alzahrani,
  • Talal Hamed Almutairi,
  • Bader Ahmed S. Alzahrani and
  • Abdulelah Saleh Saeed Albeshri
  • + 3 authors+ 0 author

21 July 2022

Backgroundand objectives: Although several vaccines have been produced and administered around the world, new SARS-CoV-2 worsened the COVID-19 infection risk and impacted the initial vaccine dosage effectiveness. Based on studies indicating that the...

(This article belongs to the Special Issue New Trends in Autoimmunity and Vaccines)
  • Article
  • Open Access
26 Citations
5,800 Views
20 Pages

21 July 2022

Background and Objectives: Despite the importance of life satisfaction for health and well-being, there is a paucity of cross-national comparative studies in life satisfaction related to the family environment. The present research examined the pathw...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
8 Citations
3,565 Views
10 Pages

21 July 2022

Background and Objectives: Atherosclerosis is a disease in the pathogenesis of which plasma factors apart from elevated cholesterol levels play a keyrole. Such factors include osteopontin (OPN), osteoprotegerin (OPG), and metalloproteinases (MMPs), w...

(This article belongs to the Special Issue New Insights into Ischemic Heart Disease: Diagnosis, Risk Assessment, Prevention and Treatment Strategies)
  • Case Report
  • Open Access
3 Citations
3,691 Views
6 Pages

Case Report of Neonatal Sotos Syndrome with a New Missense Mutation in the NSD1 Gene and Literature Analysis in the Chinese Han Population

  • Hui-Ying Jin,
  • Hai-Feng Li,
  • Jia-Lu Xu,
  • Wang Hui and ,
  • Wen-Cong Ruan,
  • Cheng-Cheng Lv,
  • Ren-Ai Xu and
  • Shu Qiang
  • + 3 authors+ 0 author

21 July 2022

Currently, no consensus exists regarding Sotos syndrome in the Chinese population. Here, we present a case of neonatal Sotos syndrome, followed by a retrospective analysis of five cases of neonatal Sotos syndrome, reported in China. The study subject...

  • Case Report
  • Open Access
3 Citations
3,314 Views
8 Pages

Extreme Interocular Asymmetry in an Atypical Case of a Hydroxychloroquine-Related Retinopathy

  • Gabriel Hallali,
  • Zari Seyed,
  • Anne-Véronique Maillard,
  • Karima Drine and ,
  • Laurence Lamour,
  • Céline Faure and
  • Isabelle Audo
  • + 2 authors+ 0 author

21 July 2022

Background and Objectives: Long-term hydroxychloroquine (HCQ) therapy can lead to retinal toxicity. Typically, it is characterized by a bull’s eye maculopathy. More recently, a “pericentral” form of HCQ retinopathy that predominantl...

(This article belongs to the Section Ophthalmology)
  • Review
  • Open Access
38 Citations
11,714 Views
19 Pages

Nutritional Interventions to Improve Cachexia Outcomes in Cancer—A Systematic Review

  • Adina Braha,
  • Alin Albai,
  • Bogdan Timar,
  • Șerban Negru and ,
  • Săftescu Sorin,
  • Deiana Roman and
  • Dorel Popovici
  • + 2 authors+ 0 author

21 July 2022

Background and Objectives: The prevalence of cachexia has increased across all of the cancer types and accounts for up to 20% of cancer-related deaths. This paper is a systematic review of nutritional interventions aiming to improve cachexia outcomes...

(This article belongs to the Section Endocrinology)
  • Article
  • Open Access
2 Citations
3,062 Views
9 Pages

Coronary CT Value in Quantitative Assessment of Intermediate Stenosis

  • Laura Zajančkauskienė,
  • Laura Radionovaitė,
  • Antanas Jankauskas,
  • Audra Banišauskaitė and
  • Gintarė Šakalytė

20 July 2022

Background and Objectives: Cardiac computed tomography angiography (CCTA) is an excellent non-invasive imaging tool to evaluate coronary arteries and exclude coronary artery disease (CAD). Managing intermediate coronary artery stenosis with negative...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
22 Citations
8,331 Views
7 Pages

Neonatal Pneumothorax Outcome in Preterm and Term Newborns

  • Miljana Z. Jovandaric,
  • Svetlana J. Milenkovic,
  • Jelena Dotlic,
  • Ivana R. Babovic and ,
  • Zorica Jestrovic,
  • Branislav Milosevic,
  • Miljan Culjic and
  • Sandra Babic
  • + 3 authors+ 0 author

20 July 2022

Background and Objectives: Pneumothorax implies the presence of air in the pleural space between the visceral and parietal pleura. The aim of this study was to investigate the incidence, clinical characteristics, risk factors, therapy and perinatal o...

  • Systematic Review
  • Open Access
31 Citations
4,435 Views
13 Pages

Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis

  • Andrea Frosolini,
  • Leonardo Franz,
  • Antonio Daloiso,
  • Andrea Lovato and ,
  • Cosimo de Filippis and
  • Gino Marioni
  • + 1 author+ 0 author

20 July 2022

Background and Objectives: Sudden Sensorineural Hearing Loss (SSNHL) is a quite common clinical finding in otolaryngology. Most cases are classified as idiopathic and there is a dearth of information on factors able to predict the response to treatme...

(This article belongs to the Section Neurology)
  • Article
  • Open Access
8 Citations
2,936 Views
8 Pages

20 July 2022

Background and Objectives: A third of the American adult population is currently pre-diabetic/morbidly obese and is, therefore, at an elevated risk for developing type 2 diabetes. Unfortunately, such a condition does not spare children from also deve...

(This article belongs to the Section Endocrinology)
  • Article
  • Open Access
1 Citations
4,250 Views
9 Pages

Maladaptive Personality Traits in a Group of Patients with Substance Use Disorder and ADHD

  • Alexandra Mariana Buică,
  • Diana Monica Preda,
  • Lucia Emanuela Andrei,
  • Mihaela Stancu and ,
  • Nicolae Gică and
  • Florina Rad
  • + 1 author+ 0 author

20 July 2022

Background and Objectives: the comorbidity of personality disorders in patients who use psychoactive substances is common in psychiatric practice. The epidemiology of disharmonious personality traits in patients with ADHD and addictions in adulthood...

(This article belongs to the Section Psychiatry)
  • Case Report
  • Open Access
5 Citations
5,310 Views
7 Pages

Superficial Femoral Artery Recanalization Using Fiber Optic RealShape Technology

  • Jurre Klaassen,
  • Joost A. van Herwaarden,
  • Martin Teraa and
  • Constantijn E. V. B. Hazenberg

20 July 2022

Purpose: Report of a successful case of endovascular recanalization of an occluded superficial femoral artery (SFA) using Fiber Optic RealShape (FORS) technology. Case Report: A 79-year-old male was referred for evaluation of multiple ischemic pretib...

(This article belongs to the Special Issue Modern Endovascular Therapy for Peripheral Arterial Disease)
  • Article
  • Open Access
9 Citations
3,820 Views
13 Pages

Online Learning versus Hands-On Learning of Basic Ocular Ultrasound Skills: A Randomized Controlled Non-Inferiority Trial

  • Soo-Yeon Kang,
  • Jonghoon Yoo,
  • Sookyung Park,
  • Ik-Joon Jo and ,
  • Seonwoo Kim,
  • Hyun Cho,
  • Guntak Lee,
  • Jong-Eun Park,
  • Taerim Kim and
  • Hee Yoon
  • + 9 authors+ 4 authors

20 July 2022

Background and objectives: Ocular ultrasound is a core application of point-of-care ultrasound (POCUS) to assist physicians in promptly identifying various ocular diseases at the bedside; however, hands-on POCUS training is challenging during a pande...

(This article belongs to the Section Emergency Medicine)
  • Case Report
  • Open Access
4 Citations
4,269 Views
7 Pages

20 July 2022

Background and objectives: Coffin-Lowry Syndrome (CLS), a rare neurodegenerative disorder, is mainly diagnosed based on clinical manifestations and molecular analyses. In total, about 20 cases of CLS have been reported in China. Here, we report two c...

(This article belongs to the Section Pediatrics)
  • Article
  • Open Access
3 Citations
2,481 Views
11 Pages

19 July 2022

Background and Objectives: The influence of periostin on the growth of the patella tendon (PT) tibial insertion is unknown. The research described here aimed to reveal the contribution of periostin to the growth of fibrocartilage layers of the PT tib...

(This article belongs to the Section Sports Medicine and Sports Traumatology)
  • Editorial
  • Open Access
6 Citations
4,489 Views
3 Pages

19 July 2022

In the last decades, several new and modern techniques have been developed for the continuous monitoring of vitals for patients undergoing surgery under general anesthesia. These complex methods are meant to come as an adjunct to classical monitoring...

(This article belongs to the Special Issue General Anesthesia as a Multimodal Individualized Clinical Concept)
  • Article
  • Open Access
5 Citations
3,718 Views
12 Pages

Iron Status in Pregnant Women in Latvia: An Epidemiological, Cross-Sectional, Multicenter Study According to WHO and UK Criteria

  • Roberta Rezgale,
  • Iveta Pudule,
  • Vinita Cauce,
  • Kristine Klaramunta Antila and ,
  • Violeta Bule,
  • Gunta Lazdane,
  • Dace Rezeberga and
  • Laila Meija
  • + 3 authors+ 0 author

19 July 2022

Background and Objectives: During pregnancy, iron deficiency anaemia is a common problem associated with health risks for both the mother and her foetus/infant. This study aimed to investigate the prevalence of iron deficiency, iron deficiency anaemi...

(This article belongs to the Section Epidemiology & Public Health)
  • Review
  • Open Access
76 Citations
10,790 Views
14 Pages

Surgical Treatment and Rehabilitation Strategies for Upper and Lower Extremity Lymphedema: A Comprehensive Review

  • Alessandro de Sire,
  • Luigi Losco,
  • Lorenzo Lippi,
  • Davide Spadoni and ,
  • Juste Kaciulyte,
  • Gokhan Sert,
  • Paola Ciamarra,
  • Marco Marcasciano,
  • Roberto Cuomo and
  • Emanuele Cigna
  • + 7 authors+ 2 authors

19 July 2022

Lymphedema is a chronic disabling condition affecting a growing number of patients worldwide. Although lymphedema is not life-threatening, several reports underlined detrimental consequences in terms of distress, pain, functional impairment, and infe...

(This article belongs to the Special Issue Vasorum Lymphaticorum: From the Discovery of the Lymphatic System to the New Perspectives in Microsurgical Reconstruction and Patient Rehabilitation)
  • Case Report
  • Open Access
10 Citations
4,318 Views
9 Pages

19 July 2022

The use of computer-aided rapid prototyping (CARP) models was considered to reduce surgical trauma and improve outcomes when autotransplantation of teeth (ATT) became a viable alternative for dental rehabilitation. However, ATT is considered techniqu...

(This article belongs to the Special Issue Outcome of Minimally Invasive Techniques in Dentistry)
  • Review
  • Open Access
54 Citations
11,656 Views
21 Pages

19 July 2022

Background and Objectives: The US Food and Drug Administration (FDA) defines a biomarker as a characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention. Biomarker...

(This article belongs to the Special Issue Commemorative Issue Celebrating the 20th Anniversary of the Alzheimer’s Foundation of America: Understanding and Treating Alzheimer’s Disease)
  • Case Report
  • Open Access
1 Citations
2,714 Views
4 Pages

Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report

  • Susanne Jung,
  • Lauren Bohner,
  • Miriam Schulte and
  • Johannes Kleinheinz

19 July 2022

Epithelioid rhabdomyosarcoma is a rare condition, which may be clinically misinterpreted as melanoma due to its morphological appearance. Careful morphological and immunohistochemical analysis play an important role in its diagnosis. This case report...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
3 Citations
4,344 Views
10 Pages

Bradycardia and Heart Rate Fluctuation Are Associated with a Prolonged Intensive Care Unit Stay in Patients with Severe COVID-19

  • Pattraporn Tajarernmuang,
  • Konlawij Trongtrakul,
  • Warawut Chaiwong,
  • Teerapat Nantsupawat and ,
  • Athavudh Deesomchok,
  • Panida Chanayat,
  • Nutchanok Niyatiwatchanchai,
  • Theerakorn Theerakittikul,
  • Atikun Limsukon and
  • Chaiwat Bumroongkit
  • + 7 authors+ 2 authors

19 July 2022

Background and Objective: Bradycardia has been observed among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is suspected to be associated with poorer outcomes. Heart rate (HR) fluctuation has been found to be...

(This article belongs to the Section Infectious Disease)
  • Review
  • Open Access
9 Citations
5,164 Views
8 Pages

Radiation-Induced Esophageal Cancer: Investigating the Pathogenesis, Management, and Prognosis

  • Athanasios Syllaios,
  • Michail Vailas,
  • Maria Tolia,
  • Nikolaos Charalampakis and ,
  • Konstantinos Vlachos,
  • Emmanouil I. Kapetanakis,
  • Periklis I. Tomos and
  • Dimitrios Schizas
  • + 3 authors+ 0 author

18 July 2022

One of the most serious late side effects of irradiation is the promotion of tumorigenesis. Radiation-induced esophageal cancer (RIEC) can arise in a previously irradiated field, mostly in patients previously irradiated for thoracic malignancies such...

(This article belongs to the Special Issue Thoracic Surgery for Lung, Pleural and Esophageal Malignancies: Current Practice and Future Directions)
  • Article
  • Open Access
8 Citations
6,321 Views
13 Pages

Reliability of Isometric Muscle Strength Measurement and Its Accuracy Prediction of Maximal Dynamic Force in People with Multiple Sclerosis

  • Kora Portilla-Cueto,
  • Carlos Medina-Pérez,
  • Ena Monserrat Romero-Pérez,
  • José Aldo Hernández-Murúa and ,
  • Carolina Vila-Chã and
  • José Antonio de Paz
  • + 1 author+ 0 author

18 July 2022

Background and Objectives: Multiple sclerosis (MS) is a disease that manifests with varied neurological symptoms, including muscle weakness, especially in the lower extremities. Strength exercises play an important role in the rehabilitation and func...

(This article belongs to the Section Sports Medicine and Sports Traumatology)
  • Article
  • Open Access
3,002 Views
8 Pages

The First Evaluation of Proteinase K-Resistant Prion Protein (PrPSc) in Korean Appendix Specimens

  • Sae-Young Won,
  • Yong-Chan Kim,
  • Yu-Ni Lee,
  • Chan-Gyun Park and ,
  • Woo-Young Kim and
  • Byung-Hoon Jeong
  • + 1 author+ 0 author

18 July 2022

Background and Objectives: Prion diseases are fatal neurodegenerative disorders caused by the abnormal proteinase K-resistant prion protein (PrPSc). Since variant Creutzfeldt–Jakob disease (CJD) was first reported in the United Kingdom (UK) in...

(This article belongs to the Section Neurology)
  • Article
  • Open Access
3 Citations
7,833 Views
9 Pages

Liver Stiffness in Obese Hypothyroid Patients Taking Levothyroxine

  • Roberta Pujia,
  • Elisa Mazza,
  • Tiziana Montalcini,
  • Franco Arturi and ,
  • Antonio Brunetti,
  • Antonio Aversa,
  • Stefano Romeo,
  • Maria Perticone,
  • Angela Sciacqua and
  • Arturo Pujia
  • + 5 authors+ 0 author

18 July 2022

Background and Objectives: Thyroid dysfunction is associated with non-alcoholic fatty liver disease, but its role in the progression of liver damage in obese patients remains unclear. In addition, several case reports have suggested the existence of...

  • Feature Paper
  • Article
  • Open Access
17 Citations
3,720 Views
12 Pages

Mortality Predictors in Severe SARS-CoV-2 Infection

  • Mihai Lazar,
  • Ecaterina Constanta Barbu,
  • Cristina Emilia Chitu,
  • Ana-Maria-Jennifer Anghel and ,
  • Cristian-Mihail Niculae,
  • Eliza-Daniela Manea,
  • Anca-Cristina Damalan,
  • Adela-Abigaela Bel,
  • Raluca-Elena Patrascu and
  • Daniela Adriana Ion
  • + 6 authors+ 1 author

18 July 2022

Background and Objectives: The severe forms of SARS-CoV-2 pneumonia are associated with acute hypoxic respiratory failure and high mortality rates, raising significant challenges for the medical community. The objective of this paper is to present th...

(This article belongs to the Special Issue Emergency Medicine and Emergency Room Medical Issues)
  • Article
  • Open Access
11 Citations
4,236 Views
10 Pages

17 July 2022

Background and Objectives: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that affects predominantly women in the childbearing years. Patients may seek complementary therapies to manage their health and to reduce symptoms...

(This article belongs to the Special Issue Rheumatic Diseases: New Progress in Clinical Research and Pathogenesis)
  • Case Report
  • Open Access
7 Citations
3,619 Views
5 Pages

Scar-Free Laparoscopy in BRCA-Mutated Women

  • Stefano Restaino,
  • Angelo Finelli,
  • Giulia Pellecchia,
  • Anna Biasioli and ,
  • Jessica Mauro,
  • Carlo Ronsini,
  • Monica della Martina,
  • Martina Arcieri,
  • Luigi Della Corte and
  • Giuseppe Vizzielli
  • + 7 authors+ 2 authors

17 July 2022

Background and Objectives: BRCA 1 and 2 mutations have a cumulative risk of developing ovarian cancer at 70 years of 41% and 15%, respectively, while a cumulative risk of breast cancer by 80 years of age was 72% for BRCA1 mutation carriers and 69% fo...

(This article belongs to the Special Issue New Insights and Perspectives in Minimally Invasive Gynecology)
  • Article
  • Open Access
49 Citations
14,211 Views
14 Pages

Anxiety and Depression in Women with Polycystic Ovary Syndrome

  • Paweł Dybciak,
  • Ewa Humeniuk,
  • Dorota Raczkiewicz,
  • Jan Krakowiak and ,
  • Artur Wdowiak and
  • Iwona Bojar
  • + 1 author+ 0 author

16 July 2022

Background and Objectives: Mental health disorders are often the consequence of hormonal disorders such as those accompanying polycystic ovary syndrome (PCOS), where changes in appearance and having to deal with a number of other problems occur due t...

(This article belongs to the Special Issue Polycystic Ovary Syndrome (PCOS) in Gynecologic Endocrinology)
  • Systematic Review
  • Open Access
21 Citations
4,941 Views
15 Pages

Vitamins C and D and COVID-19 Susceptibility, Severity and Progression: An Evidence Based Systematic Review

  • Filippo Migliorini,
  • Raju Vaishya,
  • Jörg Eschweiler,
  • Francesco Oliva and ,
  • Frank Hildebrand and
  • Nicola Maffulli
  • + 1 author+ 0 author

15 July 2022

Background and Objectives: Starting in early December 2019, the novel Coronavirus Disease (COVID-19) from infection with COVID-19 has caused a global pandemic. Many aspects of its pathogenesis and related clinical consequences are still unclear. Earl...

(This article belongs to the Section Infectious Disease)
  • Article
  • Open Access
3 Citations
3,030 Views
11 Pages

Effects of Positive End-Expiratory Pressure on Intraocular Pressure during One-Lung Ventilation in the Lateral Decubitus Position—A Prospective Randomized Trial

  • Yong Shin Kim,
  • Kwon Hui Seo,
  • Yeon Soo Jeon,
  • Jang Hyeok In and ,
  • Hong Soo Jung,
  • Yoo Jung Park,
  • Eun Hwa Jun and
  • Eunju Yu
  • + 3 authors+ 0 author

15 July 2022

Background and Objectives: The effect of positive end-expiratory pressure (PEEP) on intraocular pressure (IOP) is debatable. There have been no studies investigating the effects of PEEP on IOP during one-lung ventilation (OLV). We aimed to investigat...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
24 Citations
5,662 Views
12 Pages

Emphysema Quantification Using Ultra-Low-Dose Chest CT: Efficacy of Deep Learning-Based Image Reconstruction

  • Jeong-A Yeom,
  • Ki-Uk Kim,
  • Minhee Hwang,
  • Ji-Won Lee and ,
  • Kun-Il Kim,
  • You-Seon Song,
  • In-Sook Lee and
  • Yeon-Joo Jeong
  • + 3 authors+ 0 author

15 July 2022

Background and Objectives: Although reducing the radiation dose level is important during diagnostic computed tomography (CT) applications, effective image quality enhancement strategies are crucial to compensate for the degradation that is caused by...

(This article belongs to the Section Pulmonology)
  • Review
  • Open Access
17 Citations
6,920 Views
6 Pages

Mini-Review on the Harlequin Syndrome—A Rare Dysautonomic Manifestation Requiring Attention

  • Ioannis Mavroudis,
  • Ioana-Miruna Balmus,
  • Alin Ciobica,
  • Alina-Costina Luca and ,
  • Rumana Chowdhury,
  • Alin-Constantin Iordache,
  • Dragos Lucian Gorgan and
  • Iulian Radu
  • + 3 authors+ 0 author

15 July 2022

Harlequin syndrome (HS) is a rare autonomic disorder. The causes and risk factors of the disease are not fully understood. Some cases of HS are associated with traumatic injuries, tumors, or vascular impairments of the head. Symptoms of HS can also o...

(This article belongs to the Section Neurology)
  • Case Report
  • Open Access
8 Citations
3,309 Views
6 Pages

Surgical Treatment Following Failed Medical Treatment of an Interstitial Pregnancy

  • Stefano Restaino,
  • Elena De Gennaro,
  • Stefano Floris,
  • Guglielmo Stabile and ,
  • Giulia Zinicola,
  • Felice Sorrentino,
  • Giuseppe Vizzielli and
  • Lorenza Driul
  • + 3 authors+ 0 author

15 July 2022

Interstitial pregnancy (IP) is a type of ectopic pregnancy in which the embryo implants in the interstitial part of the Fallopian tube. It accounts for 2% of all ectopic pregnancies. Signs and symptoms appear later than the other forms of ectopic pre...

(This article belongs to the Section Obstetrics and Gynecology)
  • Systematic Review
  • Open Access
43 Citations
18,124 Views
34 Pages

The Low-Fluence Q-Switched Nd:YAG Laser Treatment for Melasma: A Systematic Review

  • Yeon Seok Lee,
  • Yu Jin Lee,
  • Jung Min Lee,
  • Tae Young Han and ,
  • June Hyunkyung Lee and
  • Jae Eun Choi
  • + 1 author+ 0 author

14 July 2022

Melasma is a common pigmentary disorder with a complex pathogenesis, of which the treatment is challenging. Conventional treatment often leads to inconsistent results with unexpected pigmentary side effects and high recurrence rates. Recently, the lo...

(This article belongs to the Special Issue Lasers, Lights and New Technologies in Medicine and Surgery)
  • Communication
  • Open Access
2 Citations
3,543 Views
9 Pages

14 July 2022

Recently, it was demonstrated that copper complexes and 3,4-diaminopyridine can effectively reduce the activity of the botulinum neurotoxin light chain. The aim of the present study was to indicate that treatment with an antidote may have a major inf...

(This article belongs to the Section Neurology)
  • Article
  • Open Access
6 Citations
3,278 Views
6 Pages

Trends in the Incidence and Severity of Injuries Sustained by Riders of Electric Bikes and Powered Scooters: A Retrospective Cross-Sectional Study

  • Bahaa Haj Yahya,
  • Helena Demetriou,
  • Adi Zelnik,
  • Nir Cohen and ,
  • Michael J. Drescher,
  • Gavriel Chaushu and
  • Yafit Hamzani
  • + 2 authors+ 0 author

14 July 2022

Background and Objectives: The worldwide increase in electric bike (E-bike) and powered scooter (P-scooter) use in recent years has been accompanied by an increase in associated injuries to riders. The aim of this study was to evaluate trends in the...

(This article belongs to the Section Emergency Medicine)
  • Article
  • Open Access
13 Citations
3,612 Views
10 Pages

Regional Variety of Reduction in Retinal Thickness of Diabetic Macular Edema after Anti-VEGF Treatment

  • Yutaka Yamada,
  • Yoshihiro Takamura,
  • Takehiro Matsumura,
  • Makoto Gozawa and ,
  • Masakazu Morioka and
  • Masaru Inatani
  • + 1 author+ 0 author

14 July 2022

Background and Objectives: The presence of refractory cases resistant to anti-vascular endothelial growth factor (VEGF) therapy for diabetic macular edema (DME) is a problem in clinical practice. This study aimed to explore the less responsive area o...

(This article belongs to the Special Issue Multidisciplinary Approaches for Managing Ophthalmic Complications of Diabetes)
  • Review
  • Open Access
3 Citations
4,701 Views
8 Pages

The Role of Nut and Seed Consumption in Colorectal Cancer: A Narrative Review

  • Deiana Roman,
  • Bogdan Timar,
  • Vlad Avram,
  • Adina Braha and ,
  • Sorin Saftescu,
  • Șerban Negru and
  • Romulus Timar
  • + 2 authors+ 0 author

14 July 2022

Given the increased incidence of colorectal cancer worldwide, especially in developed and developing countries, is comes as no surprise that researchers are concentrating on methods to combat this public health issue, through investigating both lifes...

(This article belongs to the Section Oncology)
  • Review
  • Open Access
82 Citations
23,010 Views
24 Pages

14 July 2022

The ‘Focal Infection Era in Dentistry’ in the late 19th and early 20th century resulted in widespread implementation of tooth extraction and limited the progress of endodontics. The theory proposed that bacteria and toxins entrapped in de...

(This article belongs to the Section Dentistry and Oral Health)
  • Article
  • Open Access
19 Citations
5,559 Views
11 Pages

14 July 2022

Background and Objectives: This retrospective study aims to evaluate the prevalence, radiographic features, and clinical relevancy of the accessory canals (AC) of the canalis sinuosus (CS) in patients referred for implant surgery. Materials and Metho...

(This article belongs to the Section Dentistry and Oral Health)
  • Technical Note
  • Open Access
4 Citations
6,075 Views
8 Pages

13 July 2022

Clinical outcomes after anterior cruciate ligament reconstruction (ACLR) have improved remarkably. However, residual rotational instability of the knee joint remains a major concern. The anterolateral ligament (ALL) has recently gained interest as a...

(This article belongs to the Section Sports Medicine and Sports Traumatology)
  • Case Report
  • Open Access
6 Citations
11,347 Views
7 Pages

13 July 2022

Diffuse idiopathic skeletal hyperostosis (DISH) is an ossifying and ankylosing skeletal condition that can be associated with DISH-related dysphagia in the case of cervical involvement. In contrast to most cases of dysphagia, which are managed conser...

(This article belongs to the Section Surgery)
  • Case Report
  • Open Access
2 Citations
3,928 Views
8 Pages

13 July 2022

An 80-year-old man was admitted with an L5 compression fracture, L4/5 spondylolisthesis, and L5 radiculopathy and underwent a TLIF procedure. Refractory hypotension occurred, though it indicated a possible great vessel injury with vasopressor and flu...

(This article belongs to the Section Surgery)
  • Article
  • Open Access
13 Citations
3,813 Views
12 Pages

12 July 2022

Background and Objectives: The prediction of the prognosis and effect of neoadjuvant therapy is vital for patients with advanced or unresectable colorectal carcinoma (CRC). Materials and Methods: We investigated several tumor microenvironment factors...

  • Article
  • Open Access
7 Citations
4,354 Views
12 Pages

Evaluating the Phagocytic Index of Peripheral Leukocytes in Endometriosis by Plasma Experiments

  • Luca Lukács,
  • Anna Rebeka Kovács,
  • László Pál,
  • Sándor Szűcs and
  • Rudolf Lampé

12 July 2022

Background and Objectives: Endometriosis is a benign, chronic disease, that negatively influences the quality of life of affected women and is responsible for a remarkable amount of infertility. The pathophysiology of the disease is still not clarifi...

(This article belongs to the Section Obstetrics and Gynecology)
  • Review
  • Open Access
34 Citations
9,858 Views
14 Pages

Therapeutic Strategies to Reduce Burn Wound Conversion

  • Alen Palackic,
  • Jayson W. Jay,
  • Robert P. Duggan,
  • Ludwik K. Branski and ,
  • Steven E. Wolf,
  • Naseem Ansari and
  • Amina El Ayadi
  • + 2 authors+ 0 author

11 July 2022

Burn wound conversion refers to the phenomenon whereby superficial burns that appear to retain the ability to spontaneously heal, convert later into deeper wounds in need of excision. While no current treatment can definitively stop burn wound conver...

(This article belongs to the Collection A History of Burn Care)

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Medicina - ISSN 1648-9144