Next Article in Journal
The Clinical Impact of Platelets on Post-Injury Serum Creatinine Concentration in Multiple Trauma Patients: A Retrospective Cohort Study
Previous Article in Journal
Continuous Rod Load Monitoring to Assess Spinal Fusion Status–Pilot In Vivo Data in Sheep
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Medicina
Volume 58
Issue 7
10.3390/medicina58070900
Review Report
medicina-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Case Report
Peer-Review Record

A Case of Oncocytic Adrenal Cortical Neoplasm with Uncertain Malignant Potential Turned Out to Be Oncocytic Adrenal Cortical Carcinoma with Distant Metastasis: Could Pathology Do Better Initially?

Medicina 2022, 58(7), 900; https://doi.org/10.3390/medicina58070900
by Chien-Peng Huang 1, Ming-Shen Dai 2, Chien-Chang Kao 3, Wen-Chiuan Tsai 1 and Cheng-Ping Yu 1,*
Reviewer 1: Anonymous
Reviewer 2:
Luca Cima
Medicina 2022, 58(7), 900; https://doi.org/10.3390/medicina58070900
Submission received: 2 June 2022 / Revised: 2 July 2022 / Accepted: 4 July 2022 / Published: 6 July 2022
(This article belongs to the Section Endocrinology)

Round 1

Reviewer 1 Report

This work from Chien-Peng Huang et al. describes “a case of oncocytic adrenal cortical neoplasm with uncertain malignant potential turned out to be oncocytic adrenal cortical carcinoma with distant metastasis”. Authors raise awareness of useful observations for differential diagnosis between oncocytic adrenocortical neoplasm with uncertain malignant potential and oncocytic adrenal carcinoma.

 The following comments should be taken into consideration:

Authors should include photos taken from a “hot spot” of the PHH3 immunoexpression which is the strongest indication of the initial tumor malignancy.

Secondly, additional photos should be provided from a “hot spot” of the Ki67 immunoexpression. With this demonstration, they will be able to prove the “Helsinki score” of the case reported.

Author Response

Response 1: We’ve taken photos from a “hot spot” of the PHH3 immunoexpression and gained the mitotic figure more than 5 mitoses per 50 high power fields in one of these hotspots, which met one of the major criteria of Lin-Weiss-Bisceglia histological system for diagnosing oncocytic ACC.

 

Author Response File: Author Response.docx

Reviewer 2 Report

Huang et al. reported a case of oncocytic adrenal cortical carcinoma with distant metastasis initially diagnosed as oncocytic adrenal cortical neoplasm.

This neoplasm is ultra-rare (only 56 cases described until now) and the authors added data to the shortage of literature about the diagnostic approach and histopathological characteristics.

I suggest to insert a table with the clinical and histopathological features of the metastatic cases described until now including the current one. 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.


Back to TopTop