A Clinical Prediction Model of Overall Survival for Patients with Cervical Cancer Aged 25–69 Years
Abstract
:1. Introduction
2. Methods
2.1. Data Source
2.2. Development and Validation of the Prediction Model
2.3. Statistical Analysis
3. Results
3.1. Participant Characteristics
3.2. Cox Regression Analysis
3.3. Development and Validation of the Prediction Model
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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All Patients | Alive | Dead | p Value | |
---|---|---|---|---|
N | 4116 | 3071 | 1045 | |
Age | <0.001 | |||
25–29 years | 220 (5.3%) | 180 (5.9%) | 40 (3.8%) | |
30–34 years | 461 (11.2%) | 397 (12.9%) | 64 (6.1%) | |
35–39 years | 562 (13.7%) | 466 (15.2%) | 96 (9.2%) | |
40–44 years | 657 (16.0%) | 523 (17.0%) | 134 (12.8%) | |
45–49 years | 576 (14.0%) | 428 (13.9%) | 148 (14.2%) | |
50–54 years | 547 (13.3%) | 377 (12.3%) | 170 (16.3%) | |
55–59 years | 434 (10.5%) | 290 (9.4%) | 144 (13.8%) | |
60–64 years | 366 (8.9%) | 234 (7.6%) | 132 (12.6%) | |
65–69 years | 293 (7.1%) | 176 (5.7%) | 117 (11.2%) | |
Race | <0.001 | |||
White | 3056 (74.2%) | 2314 (75.4%) | 742 (71.0%) | |
Black | 387 (9.4%) | 251 (8.2%) | 136 (13.0%) | |
Others | 673 (16.4%) | 506 (16.5%) | 167 (16.0%) | |
Primary site: | <0.001 | |||
Cervix uteri | 3031 (73.6%) | 2179 (71.0%) | 852 (81.5%) | |
Endocervix | 926 (22.5%) | 769 (25.0%) | 157 (15.0%) | |
Exocervix | 98 (2.4%) | 81 (2.6%) | 17 (1.6%) | |
Overlapping lesion | 61 (1.5%) | 42 (1.4%) | 19 (1.8%) | |
Tumor size | 30.0 (12.0, 54.2) | 22.0 (9.0, 43.5) | 54.0 (37.0, 71.0) | <0.001 |
Grade | <0.001 | |||
Grade I | 658 (16.0%) | 604 (19.7%) | 54 (5.2%) | |
Grade II | 1920 (46.6%) | 1518 (49.4%) | 402 (38.5%) | |
Grade III | 1418 (34.5%) | 886 (28.9%) | 532 (50.9%) | |
Grade IV | 120 (2.9%) | 63 (2.1%) | 57 (5.5%) | |
Combined summary stage | <0.001 | |||
Regional | 1422 (34.5%) | 906 (29.5%) | 516 (49.4%) | |
Localized | 2257 (54.8%) | 2054 (66.9%) | 203 (19.4%) | |
Distant | 437 (10.6%) | 111 (3.6%) | 326 (31.2%) | |
Pathology | <0.001 | |||
Squamous cell carcinoma | 2564 (62.3%) | 1874 (61.0%) | 690 (66.0%) | |
Adenocarcinoma | 952 (23.1%) | 807 (26.3%) | 145 (13.9%) | |
Others | 600 (14.6%) | 390 (12.7%) | 210 (20.1%) | |
Surgical treatment | <0.001 | |||
No | 1257 (30.5%) | 633 (20.6%) | 624 (59.7%) | |
Yes | 2859 (69.5%) | 2438 (79.4%) | 421 (40.3%) |
HR (95%CI) | p Value | |
---|---|---|
Age | ||
25–29 years | Reference | |
30–34 years | 0.96 [0.64, 1.42] | 0.823 |
35–39 years | 1.08 [0.74, 1.56] | 0.687 |
40–44 years | 1.10 [0.77, 1.57] | 0.599 |
45–49 years | 1.39 [0.98, 1.98] | 0.065 |
50–54 years | 1.14 [0.81, 1.62] | 0.448 |
55–59 years | 1.31 [0.92, 1.87] | 0.133 |
60–64 years | 1.37 [0.96, 1.96] | 0.083 |
65–69 years | 1.59 [1.11, 2.28] | 0.012 |
Race | ||
White | Reference | |
Black | 1.37 [1.14, 1.65] | 0.001 |
Others | 1.07 [0.90, 1.27] | 0.434 |
Primary site | <0.001 | |
Cervix uteri | Reference | |
Endocervix | 0.84 [0.69, 1.01] | 0.069 |
Exocervix | 0.89 [0.55, 1.44] | 0.629 |
Overlapping lesion | 1.27 [0.80, 2.01] | 0.308 |
Tumor size | 1.01 [1.01, 1.01] | <0.001 |
Grade | ||
Grade I | Reference | |
Grade II | 1.66 [1.24, 2.22] | 0.001 |
Grade III | 2.21 [1.65, 2.95] | <0.001 |
Grade IV | 2.83 [1.92, 4.16] | <0.001 |
Combined summary stage | ||
Regional | Reference | |
Localized | 0.43 [0.36, 0.52] | <0.001 |
Distant | 2.69 [2.32, 3.13] | <0.001 |
Pathology | ||
Squamous cell carcinoma | Reference | |
Adenocarcinoma | 1.03 [0.84, 1.26] | 0.813 |
Others | 1.46 [1.22, 1.73] | <0.001 |
Regional nodes positive | 1.02 [0.99, 1.06] | 0.226 |
Surgical treatment | <0.001 | |
No | Reference | |
Yes | 0.57 [0.49, 0.67] | <0.001 |
AUC (95%CI) | Sensitivity | Specificity | |
---|---|---|---|
1 year | 0.88 (0.84, 0.91) | 0.85 | 0.71 |
3 years | 0.84 (0.81, 0.87) | 0.71 | 0.76 |
5 years | 0.83 (0.80, 0.86) | 0.47 | 0.78 |
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Fan, W.; Lu, Q.; Liu, G. A Clinical Prediction Model of Overall Survival for Patients with Cervical Cancer Aged 25–69 Years. Medicina 2023, 59, 600. https://doi.org/10.3390/medicina59030600
Fan W, Lu Q, Liu G. A Clinical Prediction Model of Overall Survival for Patients with Cervical Cancer Aged 25–69 Years. Medicina. 2023; 59(3):600. https://doi.org/10.3390/medicina59030600
Chicago/Turabian StyleFan, Wenli, Qin Lu, and Guokun Liu. 2023. "A Clinical Prediction Model of Overall Survival for Patients with Cervical Cancer Aged 25–69 Years" Medicina 59, no. 3: 600. https://doi.org/10.3390/medicina59030600