Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Patients
2.2. Evaluation of Menopausal Symptoms
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameters | T0 | T1 | p Value |
---|---|---|---|
Hot flushes, No. (%) | |||
None | 12 (6) | 22 (11) | 0.07 |
2–3 | 56 (28) | 130 (65) | <0.001 * |
4–9 | 108 (54) | 36 (18) | <0.001 * |
>10 | 24 (12) | 12 (6) | 0.055 |
Severity of hot flushes, No. (%) | |||
None | 16 (8) | 24 (12) | 0.22 |
Mild | 62 (31) | 124 (62) | <0.001 * |
Moderate | 118 (59) | 54 (27) | <0.001 * |
Severe | 4 (2) | 0 (0) | 0.04 * |
Sweats, No. (%) | |||
None | 8 (4) | 18 (9) | 0.057 |
2–3 | 26 (13) | 66 (33) | <0.001 * |
4–9 | 156 (78) | 116 (58) | 0.06 |
>10 | 10 (5) | 0 (0) | <0.001 * |
Severity of sweats, No. (%) | |||
None | 0 (0) | 28 (14) | <0.001 * |
Mild | 10 (5) | 112 (56) | <0.001 * |
Moderate | 186 (87) | 60 (30) | <0.001 * |
Severe | 4 (4) | 0 (0) | 0.04 * |
Depressive symptoms | |||
None | 0 (0) | 24 (12) | <0.001 * |
Mild | 18 (9) | 64 (32) | <0.001 * |
Moderate | 174 (87) | 112 (56) | <0.001 * |
Severe | 8 (4) | 0 (0) | 0.005 * |
BMI, No. (%) | |||
Underweight | 6 (3) | 14 (7) | 0.08 |
Normal weight | 14 (7) | 66 (33) | <0.001 * |
Overweight | 154 (88) | 102 (51) | 0.01 * |
Obesity | 28 (14) | 18 (9) | 0.04 * |
Waist circumference | |||
Lower than 88 cm | 78 (39) | 96 (48) | 0.25 |
Greater than or equal to 88 cm | 122 (61) | 104 (52) | 0.33 |
Blood pressure, No. (%) | |||
Low | 6 (3) | 3 (1.5) | 0.32 |
Normal | 175 (87.5) | 190 (95) | 0.57 |
Elevated | 18 (9) | 7 (3.5) | 0.03 * |
High | 1 (0.5) | 0 (0) | 0.31 |
Blood glucose | |||
Normal | 98 (48) | 133 (66.5) | 0.051 |
IGT | 46 (23) | 31 (15.5) | 0.11 |
IDD | 6 (3) | 4 (2) | 0.53 |
NIDD | 52 (26) | 32 (16) | 0.04 * |
HDL Cholesterol, No. (%) | |||
Low risk | 18 (9) | 10 (5) | 0.14 |
Normal | 126 (63) | 156 (78) | 0.17 |
High risk | 56 (28) | 34 (17) | 0.03 * |
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Mainini, G.; Ercolano, S.; De Simone, R.; Iavarone, I.; Lizza, R.; Passaro, M. Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study. Medicina 2024, 60, 598. https://doi.org/10.3390/medicina60040598
Mainini G, Ercolano S, De Simone R, Iavarone I, Lizza R, Passaro M. Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study. Medicina. 2024; 60(4):598. https://doi.org/10.3390/medicina60040598
Chicago/Turabian StyleMainini, Giampaolo, Salvatore Ercolano, Raffaella De Simone, Irene Iavarone, Rosalia Lizza, and Mario Passaro. 2024. "Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study" Medicina 60, no. 4: 598. https://doi.org/10.3390/medicina60040598