Smoking-Dependent Association of Serum Brain-Derived Neurotrophic Factor with Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Subjects
2.2. Clinical Data Collection
2.3. Spirometric Analysis
2.4. Quantification of Serum BDNF Concentration
2.5. Statistical Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Data | Patients with COPD n (%) | Controls n (%) |
---|---|---|
Number | (n = 57) | (n = 19) |
Male | 42 (73.7) | 8 (42.1) |
Female | 15 (26.3) | 11 (57.9) |
Age at inclusion in this study | ||
Mean ± SEM (years) | 67.14 ± 1.31 | 55.89 ± 2.51 |
Median (range) (years) | 66.00 (40–88) | 56.00 (35–80) |
Age at diagnosis | ||
Mean ± SEM (years) | 62.47 ± 1.44 | |
Median (range) (years) | 64.00 (30–86) | |
Duration of the disease | ||
Mean ± SEM (years) | 4.69 ± 0.81 | |
Median (range) (years) | 2.00 (0–30) | |
Smoking status | ||
Non-smokers | 16 (28.1) | 11 (57.9) |
Ex-smokers | 32 (56.1) | 3 (15.8) |
Current smokers | 9 (15.8) | 5 (26.3) |
Smoking habits (packs/year) | ||
Mean ± SD (years) | 31.90 ± 2.75 | 14.17 ± 3.96 |
Median (range) | 30.00 (5–88) | 12.50 (5–30) |
COPD stage | ||
GOLD II | 36 (63.1) | |
GOLD III | 16 (28.1) | |
GOLD IV | 5 (8.8) | |
FEV1% predicted | ||
Mean ± SEM | 53.30 (±2.16) | |
FEV1/FVC% | ||
Mean ± SEM | 63.32 (±0.95) |
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Aleksandrova, E.; Dimov, D.; Tacheva, T.; Petrova, H.; Celik, K.; Vlaykova, T. Smoking-Dependent Association of Serum Brain-Derived Neurotrophic Factor with Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease. Medicina 2024, 60, 1111. https://doi.org/10.3390/medicina60071111
Aleksandrova E, Dimov D, Tacheva T, Petrova H, Celik K, Vlaykova T. Smoking-Dependent Association of Serum Brain-Derived Neurotrophic Factor with Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease. Medicina. 2024; 60(7):1111. https://doi.org/10.3390/medicina60071111
Chicago/Turabian StyleAleksandrova, Elina, Dimo Dimov, Tanya Tacheva, Hristina Petrova, Kahan Celik, and Tatyana Vlaykova. 2024. "Smoking-Dependent Association of Serum Brain-Derived Neurotrophic Factor with Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease" Medicina 60, no. 7: 1111. https://doi.org/10.3390/medicina60071111