Medicina, Volume 61, Issue 9

Background and Objectives: Lymph node management in cutaneous melanoma has undergone a paradigm shift, transitioning from routine complete lymph node dissection (CLND) to a more selective, individualized approach. This narrative review explores the h...

Background and Objectives: Remimazolam is a recently introduced benzodiazepine that has been increasingly adopted as an alternative to propofol. Although several trials have compared remimazolam with propofol, these studies have primarily focused on...

Background and Objectives: In vitro evaluation of macro and microscopic features of five resorbable barrier membranes used for Guided Bone Regeneration (GBR) in oral hard tissue surgery. Materials and Methods: Five different resorbable barrier membra...

Background and Objectives: The impact of peripheral below-the-knee (BTK) fractional flow reserve (FFR) on long-term clinical outcomes remains unknown. Materials and Methods: We enrolled 40 patients with severe BTK lesions (Rutherford 4–6). FFR...

Background and Objectives: The evaluation of the haemostatic mechanism in premature neonates remains particularly challenging, due to their immature haemostatic system, the influence of inflammation and the variety of clinical factors. This prospecti...

Background: Orthodontic auxiliaries can create plaque-retentive niches that inflame adjacent soft tissues. We compared bacterial colonization on molar bands, Nance buttons, and acrylic plates and assessed associated periodontal and palatal tissue res...

Background and Objectives: Laparoscopic surgery has evolved with the integration of robotic systems, offering enhanced precision and ergonomic benefits. However, conventional robotic systems often lack haptic feedback and are associated with high cos...

Background and Objectives: Male infertility is a growing public health concern, with up to 50% of cases lacking a clearly identifiable cause. This study aimed to assess the epidemiological characteristics of male infertility in Lithuania and evaluate...

Background and Objectives: Coronary atherosclerosis remains a leading cause of global morbidity and mortality. Chronic systemic inflammation has emerged as a key factor in atherosclerosis development. Tooth loss—often the final consequence of p...

Background and Objectives: The severe systemic response to urinary tract infections known as urosepsis is associated with significant morbidity and mortality rates. The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) a...

Background and Objectives: Oral squamous cell carcinoma (OSCC) is characterized by a high propensity for cervical lymph node metastasis, which remains a strong predictor of patient outcome. Despite advances in management, the prognosis for OSCC has n...

Background and Objectives: Hepatic steatosis is associated with an increased risk of liver-related morbidity and mortality. Although numerous studies have reported associations between depression, obesity, metabolic syndrome, and cardiovascular disea...

Background and Objectives: Early allograft dysfunction (EAD), defined as suboptimal initial graft function following liver transplantation (LT), is a serious complication associated with increased post-LT morbidity and mortality. This study aimed to...

Background/Objectives: Childhood obesity is associated with early metabolic complications, particularly insulin resistance (IR), which significantly elevates the long-term risk for type 2 diabetes and cardiovascular disease. Standard measures such as...

Background and Objectives: Sarcopenic obesity (SO), characterized by the coexistence of excess adiposity and reduced muscle mass/function, is associated with adverse outcomes in older adults. Oxidative stress has been implicated in the pathogenesis o...

Background and Objectives: Padel is becoming an increasingly popular sport, yet epidemiological data on sport-related musculoskeletal injury in Portuguese practitioners are limited. This study aimed to provide a comprehensive epidemiological analysis...

Background and Objectives: Gynecological conditions requiring surgical intervention have a profound impact on women’s physical, psychological, and social well-being. Minimally invasive procedures are increasingly preferred due to their benefits...

Background and Objectives: Despite the advances in the treatment, severe burns with total burn surface area ≥ 20% are still a major cause of mortality worldwide. Pan-immune inflammation value (PIV) is a novel and promising biomarker to predict pro...

Background and Objectives: Hematological diseases can cause lasting physical and social impairments. Illness perception and emotional functioning, influenced by stigmatization and optimism, may shape these outcomes, yet their combined effects on heal...

Background and Objectives: Atrial fibrillation (AF) in critically ill patients (CIP) is associated with worse outcomes and increased mortality in the intensive care unit (ICU). Rhythm control strategies are often unfeasible due to underlying comorbid...

Background and Objectives: Robotic-assisted partial nephrectomy (RAPN) is a preferred minimally invasive option for renal tumours, but its use in highly complex cases (RENAL score ≥ 9) remains underexplored. Only four Asian countries, India, China...

Background and Objectives: Performance of robot-assisted total knee arthroplasty (TKA) procedures has continued to increase in popularity. However, tourniquet use is necessary for longer periods of time in robot-assisted TKA than conventional manual...

Background and Objectives: Tibial tuberosity avulsion fractures are rare injuries in pediatric athletes, with limited data on the potential role of an elevated body mass index (BMI) as a risk factor. Previous studies have primarily focused on age, se...

Stroke is a leading cause of disability and the second cause of death in adults. Moreover, the incidence of stroke is continuously rising. Acute reperfusion therapies (ARTs) have revolutionized stroke medicine and have altered the natural course of a...

Background and Objectives: The clinical significance of gastrointestinal (GI) tract wall thickening incidentally detected on abdominal imaging remains unclear. This study aimed to examine the relationship between GI tract wall thickening seen in imag...

Background and Objectives: This systematic review and meta-analysis aimed to analyze the available body of published peer-reviewed randomized controlled trials (RCTs) on the effects of concurrent training (CT) on biomarkers, morphological variables,...

Background and Objectives: Normothermic ex situ heart preservation maintains donor heart viability by sustaining physiological conditions and reducing ischemic damage. However, the ideal perfusion pressure remains uncertain. This study aims to identi...

Background and Objectives: Traditionally regarded as a purely motor disorder, amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the degeneration of upper and lower motor neurons. However, it is increasing...

Background and Objectives: Thoracic epidural analgesia (TEA) is considered the gold standard for postoperative pain control following major abdominal surgery. Bilateral rectus sheath block (RSB) is a promising alternative regional technique. This stu...

Neurological disorders significantly affect ocular surface homeostasis, influencing parameters such as blink rate (BR), tear production, corneal nerve density, and sensitivity. This review summarizes recent findings on ocular surface alterations asso...

Skeletal muscle is the largest insulin-sensitive tissue in the human body, playing a crucial role in glucose homeostasis, body mobility and overall metabolic health. In obesity and type 2 diabetes (T2D), skeletal muscle undergoes structural, function...

Background and Objectives: Upadacitinib is a recently approved Janus kinase (JAK) inhibitor for the treatment of inflammatory bowel disease (IBD). Although it has been adopted for clinical use, there are limited real-world data regarding its efficacy...

Background and Objectives: Music therapy has a long tradition in palliative care, and recent studies have investigated its Neuro-Psycho-Endocrine-Immunological (NPEI) effects in terminally ill patients. Despite numerous published articles, there is a...

Background and Objectives: Post-Operative Pancreatic Fistula (POPF) is reported among 13% to 64% of cases following a distal/left pancreatectomy (D/LP). Many efforts aim to prevent the onset of POPF or reduce its clinical impact. This meta-analysis s...

Background and Objectives: The revised international prognostic scoring system (IPSS-R) remains the most widely used prognostic tool for myelodysplastic syndrome (MDS). There is growing evidence that inflammation and immunological dysregulation are i...

Background: The liver’s role as a metabolic gatekeeper positions it uniquely to influence systemic metabolic homeostasis and potentially modulate leukemogenesis through hepato-hematopoietic crosstalk. Recent observations of rare hematological m...

Background and Objectives: The positive effect of health resort treatment on long COVID symptoms has been demonstrated. However, no previous study has considered therapy duration as a factor determining treatment effectiveness. Therefore, the objecti...

Background and Objectives: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting the upper and lower motor neurons, with a bleak prognosis and few treatment options. Non-invasive brain stimulation (NIBS) techniques,...

Background and Objectives: Achilles tendon ruptures in middle-aged individuals with systemic comorbidities represent a growing clinical challenge. Revision surgery, indicated in cases of tendon re-rupture, remains technically demanding and lacks stan...

Mandibular third molar surgery is a procedure that can be accompanied by several complications, one of the most important being neurological ones, resulting from transient or permanent injury to the lingual nerve (LNI) or inferior alveolar nerve (IAN...

Background and Objectives: The autonomic nervous system (ANS) orchestrates adaptation to stress; however, its reactivity is influenced by demographic, anthropometric, and psychosocial factors. While arterial stiffness and central adiposity are establ...

Background and Objectives: To find morphological features on optical coherence tomography (OCT) and OCT-angiography (OCTA) influencing contrast sensitivity (CS) in patients with retinitis pigmentosa (RP). Materials and Methods: Cross-sectional study...

Background and Objectives: Infectious keratitis (IK) is typically managed in an outpatient setting, but patients with severe infections or significant social barriers may require hospital admission. In safety-net hospital systems, these admissions to...

Background and Objectives: Coronary obstruction (CO) is a potentially fatal complication that can occur during transcatheter aortic valve implantation (TAVI). The snorkel stenting technique was developed to mitigate the risk of CO. The aim of the cur...

Background and Objectives: The aim of this study was to evaluate the role of Indocyanine Green Angiography (ICGA) on amputation levels and the wound healing process in patients with thromboangiitis obliterans (TAO) and complex diabetes. Materials and...

Background and Objectives: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by chronic compression of the median nerve within the carpal tunnel. Patient education is a cornerstone of informed consent and postoperative outc...

Background and Objectives: Effects of allergen exposure may be modified through endogenous and exogenous factors, resulting in heterogeneity of clinical features, time course and intensity of symptoms of allergic disease. This creates challenges in a...

Background and Objectives: HER-2 expression plays a critical role in the biological behavior and treatment of gastric cancer. With the emergence of HER-2-targeted therapies, classification into negative, low, and positive groups has gained clinical i...

Background and Objectives: Obstructive sleep apnea syndrome (OSAS) and heart failure (HF) frequently coexist, amplifying cardiovascular risk through mechanisms involving chronic inflammation and autonomic dysfunction. This study investigates the impa...

Background and Objectives: Anterior cruciate ligament (ACL) rupture is one of the most frequent and debilitating knee injuries, especially among young, physically active individuals. While extensively studied in Western countries, large-scale epidemi...