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Marine Drugs, Volume 21, Issue 10

October 2023 - 47 articles

Cover Story: Cyanobacteria produce a wide diversity of non-ribosomal peptides. Of these, cyanopeptolins (CPs), the cyclic depsipeptides, belong to the most common class. Their biological activity against serine proteases has been frequently reported. This work focused on cyanopeptolins produced by the Baltic cyanobacterium, Nostoc edaphicum CCNP1411. As a result, 93 CPs, including 79 new variants, were detected and structurally characterized. This allowed us to broaden the existing knowledge about the potential of one strain to produce a large number of structural variants of one class of peptides. The structural diversity of the compounds was explored using Feature-based Molecular Networking tools. In addition, the potential of CPs as candidates for drug development was confirmed in biological assays. View this paper
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Articles (47)

  • Article
  • Open Access
6 Citations
2,502 Views
14 Pages

Heme Oxygenase-1 Is Involved in the Repair of Oxidative Damage Induced by Oxidized Fish Oil in Litopenaeus vannamei by Sulforaphane

  • Junliang Luo,
  • Yongxiong Huang,
  • Yanghui Chen,
  • Yunhao Yuan,
  • Guojian Li,
  • Shuanghu Cai,
  • Jichang Jian and
  • Shiping Yang

23 October 2023

Heme oxygenase-1 (HO-1), which could be highly induced under the stimulation of oxidative stress, functions in reducing the damage caused by oxidative stress, and sulforaphane (SFN) is an antioxidant. This study aims to investigate whether HO-1 is in...

  • Review
  • Open Access
5 Citations
3,042 Views
15 Pages

Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms

  • Wei Wang,
  • Liting Gu,
  • Jiahao Wang,
  • Xubin Hu,
  • Bin Wei,
  • Huawei Zhang,
  • Hong Wang and
  • Jianwei Chen

22 October 2023

In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. S...

  • Article
  • Open Access
7 Citations
3,552 Views
14 Pages

22 October 2023

The purpose of the study was to investigate the stability and oral delivery of DHA-encapsulated Pickering emulsions stabilized by soy protein isolate–chitosan (SPI-CS) nanoparticles (SPI-CS Pickering emulsions) under various conditions and in t...

  • Article
  • Open Access
4 Citations
3,070 Views
17 Pages

Network-Derived Radioresistant Breast Cancer Target with Candidate Inhibitors from Brown Algae: A Sequential Assessment from Target Selection to Quantum Chemical Calculation

  • Mahema Sivakumar,
  • Sheikh F. Ahmad,
  • Talha Bin Emran,
  • Paola Isabel Angulo-Bejarano,
  • Ashutosh Sharma and
  • Shiek S. S. J. Ahmed

19 October 2023

Despite significant progress in early detection and treatment, a few aggressive breast cancers still exhibit resistance to therapy. This study aimed to identify a therapeutic target for radioresistant breast cancer (RRbc) through a protein network fr...

  • Article
  • Open Access
4 Citations
2,591 Views
15 Pages

19 October 2023

Saxitoxin (STX) causes high toxicity by blocking voltage-gated sodium channels, and it poses a major threat to marine ecosystems and human health worldwide. Our work evaluated the neurotoxicity and chronic toxicology of STX to Caenorhabditis elegans...

  • Article
  • Open Access
7 Citations
2,741 Views
15 Pages

Isolation and Structure Elucidation of Novel Mycosporine-like Amino Acids from the Two Intertidal Red Macroalgae Bostrychia scorpioides and Catenella caespitosa

  • Maria Orfanoudaki,
  • Mostafa Alilou,
  • Anja Hartmann,
  • Julia Mayr,
  • Ulf Karsten,
  • Hieu Nguyen-Ngoc and
  • Markus Ganzera

18 October 2023

This study presents a phytochemical survey of two common intertidal red algal species, Bostrychia scorpioides and Catenella caespitosa, regarding their MAA (mycosporine-like amino acid) composition, which are known as biogenic sunscreen compounds. Si...

  • Article
  • Open Access
4 Citations
2,585 Views
14 Pages

18 October 2023

It is evident that zinc supplementation is essential for maintaining good health and preventing disease. In this study, a novel oyster peptide–zinc complex with an average molecular weight of 500 Da was prepared from oyster meat and purified us...

  • Article
  • Open Access
9 Citations
2,293 Views
11 Pages

Pimarane-Type Diterpenes with Anti-Inflammatory Activity from Arctic-Derived Fungus Eutypella sp. D-1

  • Yaodong Ning,
  • Shi Zhang,
  • Te Zheng,
  • Yao Xu,
  • Song Li,
  • Jianpeng Zhang,
  • Binghua Jiao,
  • Yun Zhang,
  • Zengling Ma and
  • Xiaoling Lu

18 October 2023

The Arctic-derived fungus Eutypella sp. D-1 can produce numerous secondary metabolites, and some compounds exhibit excellent biological activity. Seven pimarane-type diterpenes, including three new compounds eutypellenone F (1), libertellenone Y (2),...

  • Article
  • Open Access
1 Citations
2,440 Views
22 Pages

17 October 2023

We previously examined the cellular uptake of six types of vitamin D in human intestinal Caco-2 cells. Since vitamins D5–D7 were commercially unavailable, we synthesized these compounds organically before studying them. This process led us to u...

  • Review
  • Open Access
15 Citations
4,515 Views
80 Pages

Coral Lipids

  • Andrey B. Imbs and
  • Valery M. Dembitsky

15 October 2023

Reef-building corals, recognized as cornerstone species in marine ecosystems, captivate with their unique duality as both symbiotic partners and autotrophic entities. Beyond their ecological prominence, these corals produce a diverse array of seconda...

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Mar. Drugs - ISSN 1660-3397Creative Common CC BY license