Curcumin Attenuates Doxorubicin-Induced Cardiac Oxidative Stress and Increases Survival in Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Experimental Animals
2.2. DOX and CUR Treatment
2.3. Histopathological Analysis of Cardiac Tissue
2.4. Biochemical Evaluation of Oxidative Stress
2.5. Statistical Analysis
3. Results
3.1. Curcumin Reduces DOX-Induced Mortality in Mice
3.2. Protective Effects of CUR on DOX-Induced Cardiac Tissue Damage
3.3. Evaluation of Oxidative Stress
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Arruda, F.S.; Tomé, F.D.; Milhomem, A.C.; Franco, P.I.R.; Justino, A.B.; Franco, R.R.; Campos, E.C.; Espindola, F.S.; Soave, D.F.; Celes, M.R.N. Curcumin Attenuates Doxorubicin-Induced Cardiac Oxidative Stress and Increases Survival in Mice. Pharmaceutics 2024, 16, 1105. https://doi.org/10.3390/pharmaceutics16081105
Arruda FS, Tomé FD, Milhomem AC, Franco PIR, Justino AB, Franco RR, Campos EC, Espindola FS, Soave DF, Celes MRN. Curcumin Attenuates Doxorubicin-Induced Cardiac Oxidative Stress and Increases Survival in Mice. Pharmaceutics. 2024; 16(8):1105. https://doi.org/10.3390/pharmaceutics16081105
Chicago/Turabian StyleArruda, Felipe S., Fernanda D. Tomé, Anália C. Milhomem, Pablo I. R. Franco, Allisson B. Justino, Rodrigo R. Franco, Erica C. Campos, Foued S. Espindola, Danilo F. Soave, and Mara Rubia N. Celes. 2024. "Curcumin Attenuates Doxorubicin-Induced Cardiac Oxidative Stress and Increases Survival in Mice" Pharmaceutics 16, no. 8: 1105. https://doi.org/10.3390/pharmaceutics16081105