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Pharmaceutics, Volume 6, Issue 2

2014 June - 8 articles

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Articles (8)

  • Review
  • Open Access
74 Citations
13,069 Views
21 Pages
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Inhalable PEGylated Phospholipid Nanocarriers and PEGylated Therapeutics for Respiratory Delivery as Aerosolized Colloidal Dispersions and Dry Powder Inhalers

  • Priya Muralidharan,
  • Evan Mallory,
  • Monica Malapit,
  • Don Hayes and
  • Heidi M. Mansour
Pharmaceutics2014, 6(2), 333-353;https://doi.org/10.3390/pharmaceutics6020333

20 June 2014

Nanomedicine is making groundbreaking achievements in drug delivery. The versatility of nanoparticles has given rise to its use in respiratory delivery that includes inhalation aerosol delivery by the nasal route and the pulmonary route. Due to the...

Full Article
  • Review
  • Open Access
221 Citations
23,343 Views
35 Pages
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Layered Double Hydroxide-Based Nanocarriers for Drug Delivery

  • Xue Bi,
  • Hui Zhang and
  • Liguang Dou
Pharmaceutics2014, 6(2), 298-332;https://doi.org/10.3390/pharmaceutics6020298

17 June 2014

Biocompatible clay materials have attracted particular attention as the efficient drug delivery systems (DDS). In this article, we review developments in the use of layered double hydroxides (LDHs) for controlled drug release and delivery. We show ho...

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  • Article
  • Open Access
11 Citations
7,936 Views
13 Pages
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Preliminary Studies on Validation of Calu-3 Cell Line as a Model for Screening Respiratory Mucosa Irritation and Toxicity

  • Chibueze Ihekwereme,
  • Charles Esimone,
  • Di Shao and
  • Remigius U. Agu
Pharmaceutics2014, 6(2), 268-280;https://doi.org/10.3390/pharmaceutics6020268

13 June 2014

There is need to develop reproducible methods and experimental models for screening mucosal irritation and toxicity for drugs and pharmaceutical excipients. The aim of this study was to validate Calu-3 cell line as a model for screening respiratory i...

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  • Article
  • Open Access
21 Citations
8,505 Views
17 Pages
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Development of Multilayer Microcapsules by a Phase Coacervation Method Based on Ionic Interactions for Textile Applications

  • Sudipta Chatterjee,
  • Fabien Salaün and
  • Christine Campagne
Pharmaceutics2014, 6(2), 281-297;https://doi.org/10.3390/pharmaceutics6020281

13 June 2014

The present study describes the development of multilayer microcapsules by 11 alternate additions of chitosan (Chi) and sodium dodecyl sulfate (SDS) in a combined emulsification and phase coacervation method based on ionic interactions. After an alk...

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  • Review
  • Open Access
46 Citations
14,384 Views
19 Pages
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Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges

  • Ankit Parikh,
  • Utkarshini Anand,
  • Malachy C. Ugwu,
  • Tiam Feridooni,
  • Emad Massoud and
  • Remigius U. Agu
Pharmaceutics2014, 6(2), 249-267;https://doi.org/10.3390/pharmaceutics6020249

27 May 2014

Chronic inflammation and infection of the nasal sinuses, also referred to as Chronic Rhinosinusitis (CRS), severely affects patients’ quality of life. Adhesions, ostial stenosis, infection and inflammation relapses complicate chronic sinusitis treat...

Full Article
  • Article
  • Open Access
39 Citations
9,089 Views
14 Pages
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Influence of Hydrothermal Treatment on Physicochemical Properties and Drug Release of Anti-Inflammatory Drugs of Intercalated Layered Double Hydroxide Nanoparticles

  • Zi Gu,
  • Aihua Wu,
  • Li Li and
  • Zhi Ping Xu
Pharmaceutics2014, 6(2), 235-248;https://doi.org/10.3390/pharmaceutics6020235

22 May 2014

The synthesis method of layered double hydroxides (LDHs) determines nanoparticles’ performance in biomedical applications. In this study, hydrothermal treatment as an important synthesis technique has been examined for its influence on the physicoch...

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  • Article
  • Open Access
55 Citations
14,603 Views
15 Pages
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Human Growth Hormone Delivery with a Microneedle Transdermal System: Preclinical Formulation, Stability, Delivery and PK of Therapeutically Relevant Doses

  • Mahmoud Ameri,
  • Miryam Kadkhodayan,
  • Joe Nguyen,
  • Joseph A. Bravo,
  • Rebeca Su,
  • Kenneth Chan,
  • Ahmad Samiee and
  • Peter E. Daddona
Pharmaceutics2014, 6(2), 220-234;https://doi.org/10.3390/pharmaceutics6020220

15 May 2014

This study evaluated the feasibility of coating formulated recombinant human growth hormone (rhGH) on a titanium microneedle transdermal delivery system, Zosano Pharma (ZP)-hGH, and assessed preclinical patch delivery performance. Formulation rheolog...

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  • Review
  • Open Access
63 Citations
12,367 Views
25 Pages
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Analytical Challenges and Regulatory Requirements for Nasal Drug Products in Europe and the U.S.

  • Sabrina Trows,
  • Klaus Wuchner,
  • Rene Spycher and
  • Hartwig Steckel
Pharmaceutics2014, 6(2), 195-219;https://doi.org/10.3390/pharmaceutics6020195

11 April 2014

Nasal drug delivery can be assessed by a variety of means and regulatory agencies, e.g., the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have published a set of guidelines and regulations proposing in vitro test methods...

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