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Nutrients, Volume 15, Issue 23

2023 December-1 - 161 articles

Cover Story: Achieving optimal glucose control in individuals with type 1 diabetes (T1DM) continues to pose a significant challenge. While continuous insulin infusion systems have shown promise as an alternative to conventional insulin therapy, there remains a crucial need for greater awareness regarding the necessary adaptations for various special circumstances. Nutritional choices play an essential role in the efficacy of diabetes management and overall health status for patients with T1DM. Factors such as effective carbohydrate counting, assessment of the macronutrient composition of meals, and comprehending the concept of the glycemic index of foods are paramount in making informed pre-meal adjustments when utilizing insulin pumps. View this paper
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Articles (161)

  • Article
  • Open Access
2 Citations
2,538 Views
18 Pages

Development and Functionality of a Parsimonious Digital Food Frequency Questionnaire for a Clinical Intervention among an Indigenous Population

  • Kathleen Abu-Saad,
  • Moran Accos,
  • Arnona Ziv,
  • Fiona Collins,
  • Carrington Shepherd,
  • Sandra Eades and
  • Ofra Kalter-Leibovici

4 December 2023

Nutrition-related chronic diseases are a major problem among Indigenous populations. Appropriate dietary intake assessment tools are needed for nutritional surveillance and intervention; however, tools designed to measure the habitual dietary intake...

  • Article
  • Open Access
11 Citations
3,290 Views
15 Pages

4 December 2023

Background: The edible fungus Auricularia delicate (ADe) is commonly employed in traditional medicine for intestinal disorders; however, its inhibitory effect on colitis-associated colorectal cancer (CAC) and the underlying mechanisms remain unexplor...

  • Article
  • Open Access
9 Citations
3,588 Views
12 Pages

4 December 2023

Lung cancer is the second most commonly diagnosed cancer and has the highest mortality rate worldwide despite the remarkable advances in its treatment. Origanum majorana Essential Oil (OMEO) has been shown to be effective against non-small cell lung...

  • Article
  • Open Access
17 Citations
5,725 Views
17 Pages

4 December 2023

Objective: To evaluate the genetic causality between alcohol intake, smoking, coffee consumption, and arthritis. Methods: Mendelian randomization (MR) studies with alcohol, smoking, and coffee consumption behaviors as exposures, and osteoarthritis (O...

  • Article
  • Open Access
10 Citations
4,097 Views
13 Pages

4 December 2023

(1) Background: Both tooth loss and diabetes have high global prevalence, and both have a significant influence on patients’ general health and quality of life. Previous research has indicated a possible connection between tooth loss and diabet...

  • Article
  • Open Access
14 Citations
4,694 Views
14 Pages

Thyme Extract Alleviates High-Fat Diet-Induced Obesity and Gut Dysfunction

  • Yu Ra Lee,
  • Hye-Bin Lee,
  • Mi-Jin Oh,
  • Yoonsook Kim and
  • Ho-Young Park

4 December 2023

Prolonged intake of a high-fat diet (HFD) disturbs the composition of gut microbiota, contributing to the development of metabolic diseases, notably obesity and increased intestinal permeability. Thyme (Thymus vulgaris L.), an aromatic plant, is know...

  • Article
  • Open Access
6 Citations
4,192 Views
13 Pages

4 December 2023

Worldwide, several food-based dietary guidelines, with diverse food-grouping methods in various countries, have been developed to maintain and promote public health. However, standardized international food-grouping methods are scarce. In this study,...

  • Review
  • Open Access
25 Citations
9,323 Views
33 Pages

3 December 2023

Different dietary interventions, especially intermittent fasting, are widely used and promoted by physicians; these regimens have been studied lately for their impact on the gut microbiota composition/function and, consequently, on the general physio...

  • Article
  • Open Access
7 Citations
3,964 Views
18 Pages

Exercise and Caloric Restriction Exert Different Benefits on Skeletal Muscle Metabolism in Aging Condition

  • Chanisa Thonusin,
  • Patcharapong Pantiya,
  • Aphisek Kongkaew,
  • Wichwara Nawara,
  • Busarin Arunsak,
  • Sirawit Sriwichaiin,
  • Nipon Chattipakorn and
  • Siriporn C. Chattipakorn

3 December 2023

Exercise and caloric restriction improve skeletal muscle metabolism. However, the benefits of exercise and caloric restriction on skeletal muscle metabolism in aging have never been compared. Seven-week-old male Wistar rats (n = 24) were divided into...

  • Article
  • Open Access
1 Citations
3,526 Views
16 Pages

Chrono-Nutritional Patterns, Medical Comorbidities, and Psychological Status in Patients with Severe Obesity

  • Silvia Bettini,
  • Sami Schiff,
  • Enrico Carraro,
  • Chiara Callegari,
  • Beatrice Gusella,
  • Giulia Maria Pontesilli,
  • Matteo D’Angelo,
  • Valeria Baldan,
  • Alessandra Zattarin and
  • Luca Busetto
  • + 5 authors

3 December 2023

Chrono-nutrition studies dietary habits and their role in the onset of metabolic diseases. The aim of this study is to describe chrono-nutritional patterns based on the analysis of the eating habits of patients with severe obesity during the 24-h cyc...

  • Article
  • Open Access
5 Citations
8,247 Views
11 Pages

Carrot Juice Intake Affects the Cytokine and Chemokine Response in Human Blood after Ex Vivo Lipopolysaccharide-Induced Inflammation

  • Morten Kobaek-Larsen,
  • Ulrik Deding,
  • Issam Al-Najami,
  • Bettina Hjelm Clausen and
  • Lars Porskjær Christensen

2 December 2023

In vitro and animal studies have shown that carrot juice containing bioactive natural products, such as falcarinol (FaOH) and falcarindiol (FaDOH), can affect inflammation. The present study was designed to test whether oral intake of carrot juice co...

  • Article
  • Open Access
5 Citations
3,368 Views
16 Pages

The Effect of Iron-Fortified Lentils on Blood and Cognitive Status among Adolescent Girls in Bangladesh

  • Amy L. Barnett,
  • Michael J. Wenger,
  • Fakir M. Yunus,
  • Chowdhury Jalal and
  • Diane M. DellaValle

2 December 2023

Background: Iron deficiency is highly prevalent in South Asia, especially among women and children in Bangladesh. Declines in cognitive performance are among the many functional consequences of iron deficiency. Objective: We tested the hypothesis tha...

  • Article
  • Open Access
1 Citations
4,031 Views
10 Pages

2 December 2023

Dysregulated food craving is a complex weight-related behavior. To identify novel targets for enhancing the efficacy of weight loss interventions, we examined whether food craving varies across the menstrual cycle according to the abdominal obesity t...

  • Review
  • Open Access
15 Citations
5,864 Views
12 Pages

2 December 2023

Consuming a diet that meets energy demands and provides essential nutrients promotes a healthy immune system, while both under- and over-nutrition have been associated with immune dysfunction. Military personnel comprise a unique population who frequ...

  • Article
  • Open Access
8 Citations
4,541 Views
14 Pages

Adherence to a Traditional Mexican Diet Is Associated with Lower Hepatic Steatosis in US-Born Hispanics of Mexican Descent with Overweight or Obesity

  • Melissa Lopez-Pentecost,
  • Martha Tamez,
  • Josiemer Mattei,
  • Elizabeth T. Jacobs,
  • Cynthia A. Thomson and
  • David O. Garcia

2 December 2023

Hispanics of Mexican descent have disproportionate rates of non-alcoholic fatty liver disease (NAFLD). The purpose of this work is to investigate the association between the traditional Mexican diet score (tMexS) and hepatic steatosis and fibrosis, t...

  • Review
  • Open Access
9 Citations
4,904 Views
14 Pages

The Ketogenic Diet in the Prevention of Migraines in the Elderly

  • Michal Fila,
  • Jan Chojnacki,
  • Elzbieta Pawlowska,
  • Piotr Sobczuk,
  • Cezary Chojnacki and
  • Janusz Blasiak

2 December 2023

Migraines display atypical age dependence, as the peak of their prevalence occurs between the ages of 20–40 years. With age, headache attacks occur less frequently and are characterized by a lower amplitude. However, both diagnosis and therapy...

  • Brief Report
  • Open Access
2 Citations
5,781 Views
10 Pages

2 December 2023

Nutrient adequacy among adolescents is of concern due to higher nutrient requirements for their developing bodies as well as the gap between the current nutrient intake and the recommendations. The objective of this study was to determine beef intake...

  • Article
  • Open Access
3 Citations
2,371 Views
14 Pages

Modifiable Risk Factors and Trends in Changes in Glucose Regulation during the First Three Years Postdelivery: The St Carlos Gestational Diabetes Mellitus Prevention Cohort

  • Maria Arnoriaga-Rodriguez,
  • Verónica Melero,
  • Ana Barabash,
  • Johanna Valerio,
  • Laura del Valle,
  • Rocio Martin O’Connor,
  • Paz de Miguel,
  • José A. Diaz,
  • Cristina Familiar and
  • Alfonso L. Calle-Pascual
  • + 10 authors

1 December 2023

Objective: Evaluation of the influence of potential risk factors (RFs) on glycemic changes at 3 years postpartum. Methods: The glycemic status of 1400 women, in absence of a new pregnancy, was evaluated at 3 months (3 m) and 3 years (3 y) postpartum,...

  • Article
  • Open Access
10 Citations
8,966 Views
18 Pages

1 December 2023

Expert groups recommend that populations adopt dietary patterns higher in whole, plant-based foods and lower in red and processed meat as a high-impact climate action. Yet, there is limited understanding of populations’ willingness to adopt pla...

  • Article
  • Open Access
7 Citations
3,081 Views
12 Pages

1 December 2023

Sarcopenia is a poor prognostic factor in patients with chronic kidney disease (CKD). Adequate dietary patterns are important for preventing sarcopenia; however, evidence regarding the underlying association between sarcopenia and diet is insufficien...

  • Article
  • Open Access
12 Citations
3,740 Views
16 Pages

1 December 2023

Inflammatory bowel disease (IBD) is a chronic disease associated with overactive inflammation and gut dysbiosis. Owing to the beneficial effects of bifidobacteria on IBD treatment, this study aimed to investigate the anti-inflammation effects of an e...

  • Article
  • Open Access
5 Citations
3,000 Views
19 Pages

Protective Effect of Alpha-Linolenic Acid on Human Oral Squamous Cell Carcinoma Metastasis and Apoptotic Cell Death

  • Ching-Chyuan Su,
  • Cheng-Chia Yu,
  • Yi-Wen Shih,
  • Kai-Li Liu,
  • Haw-Wen Chen,
  • Chih-Chung Wu,
  • Ya-Chen Yang,
  • En-Ling Yeh and
  • Chien-Chun Li

1 December 2023

Oral cancer ranks sixth among Taiwan’s top 10 cancers and most patients with poor prognosis acquire metastases. The essential fatty acid alpha-linolenic acid (ALA) has been found to diminish many cancer properties. However, the anti-cancer acti...

  • Article
  • Open Access
6 Citations
2,144 Views
10 Pages

1 December 2023

Phase angle (PhA) is measured using bioimpedance analysis and calculated using body reactance and resistance in the waveform at 50 kHz. Further studies are necessary to clarify the predictive efficacy of PhA in the mortality of peritoneal dialysis (P...

  • Article
  • Open Access
19 Citations
6,535 Views
13 Pages

Observational Cross-Sectional Study on Mediterranean Diet and Sperm Parameters

  • Gabriel Cosmin Petre,
  • Francesco Francini-Pesenti,
  • Andrea Di Nisio,
  • Luca De Toni,
  • Giuseppe Grande,
  • Asia Mingardi,
  • Arianna Cusmano,
  • Paolo Spinella,
  • Alberto Ferlin and
  • Andrea Garolla

1 December 2023

Infertility, affecting 15 to 25% of couples in the most developed countries, is recognized by the World Health Organization as a public health issue at a global level. Different causes are acknowledged to reduce fertility in both sexes. In particular...

  • Article
  • Open Access
3 Citations
1,942 Views
12 Pages

1 December 2023

Antimicrobial photodynamic treatment (aPDT) with visible light plus water-filtered infrared-A irradiation (VIS-wIRA) and natural single- or multi-component photosensitizers (PSs) was shown to have potent antimicrobial activity. The aim of this study...

  • Review
  • Open Access
12 Citations
7,411 Views
16 Pages

1 December 2023

Diabetes is a chronic condition that can lead to various complications; therefore, there is a need to emphasize prevention and management. Dietary interventions, such as the Mediterranean diet or calorie-restricted regimens, coupled with exercise-ind...

  • Article
  • Open Access
16 Citations
4,098 Views
17 Pages

Neuroprotective Effects of N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline (NMP) against Amyloid-β-Induced Alzheimer’s Disease Mouse Model

  • Jawad Ali,
  • Amjad Khan,
  • Jun Sung Park,
  • Muhammad Tahir,
  • Waqas Ahmad,
  • Kyonghwan Choe and
  • Myeong Ok Kim

1 December 2023

Alzheimer’s disease (AD), is a progressive neurodegenerative disorder that involves the deposition of β-amyloid plaques and the clinical symptoms of confusion, memory loss, and cognitive dysfunction. Despite enormous progress in the field,...

  • Article
  • Open Access
4 Citations
6,927 Views
14 Pages

1 December 2023

Lactobacillus paragasseri OLL2809 has been shown to ameliorate stress. This study employed a randomized, placebo-controlled, double-blind, parallel-group design to assess the efficacy of continuous ingestion of OLL2809 for managing menstrual symptoms...

  • Review
  • Open Access
7 Citations
18,973 Views
12 Pages

The Role of Nutrition in Pathogenesis of Uterine Fibroids

  • Jarosław Krzyżanowski,
  • Tomasz Paszkowski and
  • Sławomir Woźniak

1 December 2023

Uterine fibroids are benign tumors that arise from the smooth muscle tissue of the uterus and are the most common tumors in women. Due to their high prevalence, costs for the health care system and the substantial impact on women’s quality of l...

  • Article
  • Open Access
1 Citations
3,852 Views
14 Pages

1 December 2023

Nutrition intake plays a pivotal role in chewing difficulty (CD). This cross-sectional descriptive study aims to explore the associations between CD and the dietary intake of calcium (Ca), vitamin D, and magnesium (Mg) in adults aged 65 and older, ut...

  • Article
  • Open Access
2,303 Views
18 Pages

How Can We Find Out What Indigenous Children and Their Families Need to Manage Weight? Lessons from Formative Nutrition Intervention Research with First Australians

  • Lauren T. Williams,
  • Mari Somerville,
  • Fiona Wright,
  • Heidi Atkins,
  • Ayala Rogany,
  • Kristie L. Bell and
  • Lisa Vincze

1 December 2023

In Australia, Indigenous children have rates of overweight and obesity 1.5 times those of non-Indigenous children. Culturally safe and effective nutrition interventions are needed for this group. This paper aims to describe a Community-based Particip...

  • Article
  • Open Access
9 Citations
4,170 Views
18 Pages

30 November 2023

Several risk factors, including nutritional/lifestyle ones, play a role in gastric cancer etiology. Further interactions with mental health have also been emphasized. We hypothesized that individuals with mental disorders would exhibit compromised nu...

  • Article
  • Open Access
10 Citations
2,697 Views
20 Pages

Potential Dietary and Therapeutic Strategies Involving Indole-3-Carbinole in Preclinical Models of Intestinal Inflammation

  • Aisha Qazi,
  • Shane Comiskey,
  • Nathan Calzadilla,
  • Fatimah Amin,
  • Anchal Sharma,
  • Ei Khin,
  • Nathaniel Holton,
  • Christopher R. Weber,
  • Seema Saksena and
  • Ravinder K. Gill
  • + 2 authors

30 November 2023

Diet–microbiota interactions are emerging as important contributors in the pathogenesis of inflammatory bowel diseases (IBD), characterized by chronic inflammation of the GI tract. The aryl hydrocarbon receptor (AhR) transcription factor regula...

  • Article
  • Open Access
6 Citations
2,820 Views
15 Pages

Diet-Related Disease Prevention in a Rural Australian Setting: Understanding Barriers, Enablers, and the Role of Rural Health Services in Supporting Changes in Local Rural Food Environments

  • Nikita Wheaton,
  • Emily Alston,
  • Vincent L. Versace,
  • Michael Field,
  • Anna Wong Shee,
  • Jane Jacobs,
  • Kathryn Backholer,
  • Steven Allender,
  • Melanie Nichols and
  • Laura Alston
  • + 5 authors

30 November 2023

Bold and comprehensive action is needed to prevent diet-related diseases in rural areas, which includes improving food environments to enable healthier dietary practices. Rural health services are integral to the health of rural populations, yet thei...

  • Review
  • Open Access
7 Citations
6,103 Views
35 Pages

Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length

  • Nikoletta Lis,
  • Demetris Lamnisos,
  • Aikaterini Bograkou-Tzanetakou,
  • Elena Hadjimbei and
  • Irene P. Tzanetakou

30 November 2023

Preterm birth (PTB), a multi-causal syndrome, is one of the global epidemics. Maternal nutrition, but also neonatal and placental telomere length (TL), are among the factors affecting PTB risk. However, the exact relationship between these factors an...

  • Article
  • Open Access
23 Citations
6,767 Views
15 Pages

Diet Change Improves Obesity and Lipid Deposition in High-Fat Diet-Induced Mice

  • Tengteng Ji,
  • Bing Fang,
  • Fang Wu,
  • Yaqiong Liu,
  • Le Cheng,
  • Yixuan Li,
  • Ran Wang and
  • Longjiao Zhu

30 November 2023

The number of obese people is increasing dramatically worldwide, and one of the major causes of obesity is excess energy due to high-fat diets. Several studies have shown that reducing food and energy intake represents a key intervention or treatment...

  • Article
  • Open Access
6 Citations
5,728 Views
26 Pages

Standards for the Use of Enteral Nutrition in Patients with Diabetes or Stress Hyperglycaemia: Expert Consensus

  • María I. Rebollo-Pérez,
  • Luna Florencio Ojeda,
  • Pedro P. García-Luna,
  • José A. Irles Rocamora,
  • Gabriel Olveira,
  • Juan Ramón Lacalle Remigio,
  • Carmen Arraiza Irigoyen,
  • Alfonso Calañas Continente,
  • Cristina Campos Martín and
  • Juana M. Rabat-Restrepo
  • + 8 authors

30 November 2023

(1) Background: Hyperglycaemia that occurs during enteral nutrition (EN) should be prevented and treated appropriately since it can have important consequences for morbidity and mortality. However, there are few quality studies in the literature rega...

  • Review
  • Open Access
2 Citations
6,676 Views
27 Pages

30 November 2023

Equestrian sport is under-researched within the sport science literature, creating a possible knowledge vacuum for athletes and support personnel wishing to train and perform in an evidence-based manner. This review aims to synthesise available evide...

  • Systematic Review
  • Open Access
15 Citations
6,430 Views
40 Pages

Dietary Intake of Masters Athletes: A Systematic Review

  • Sheran Guo,
  • Gabriella L. L. Shaoni,
  • Wendy A. Stuart-Smith,
  • Alyse J. Davies and
  • Janelle A. Gifford

30 November 2023

Dietary practices of masters athletes (MAs) may promote healthy ageing; however, they are poorly understood. The aims of this systematic review were to synthesise the literature on the dietary intakes of MAs and undertake comparisons between younger...

  • Review
  • Open Access
3,597 Views
18 Pages

Charting the Chronology of Research on Added Sugars: A Scoping Review and Evidence Map

  • Stephen A. Fleming,
  • Jennifer A. Peregoy,
  • Tristen L. Paul,
  • Maria O. Scott and
  • P. Courtney Gaine

30 November 2023

The objective of this study was to conduct a scoping review and produce a publicly available database characterizing the design and reporting elements of the literature on dietary added sugars and select health outcomes. Relevant studies published fr...

  • Article
  • Open Access
5 Citations
5,231 Views
16 Pages

Surveying Nutrient Assessment with Photographs of Meals (SNAPMe): A Benchmark Dataset of Food Photos for Dietary Assessment

  • Jules A. Larke,
  • Elizabeth L. Chin,
  • Yasmine Y. Bouzid,
  • Tu Nguyen,
  • Yael Vainberg,
  • Dong Hee Lee,
  • Hamed Pirsiavash,
  • Jennifer T. Smilowitz and
  • Danielle G. Lemay

30 November 2023

Photo-based dietary assessment is becoming more feasible as artificial intelligence methods improve. However, advancement of these methods for dietary assessment in research settings has been hindered by the lack of an appropriate dataset against whi...

  • Article
  • Open Access
9 Citations
3,378 Views
16 Pages

Combating Obesity: Harnessing the Synergy of Postbiotics and Prebiotics for Enhanced Lipid Excretion and Microbiota Regulation

  • Yueming Zhao,
  • Yaping Zheng,
  • Kui Xie,
  • Yanmei Hou,
  • Qingjing Liu,
  • Yujun Jiang,
  • Yu Zhang and
  • Chaoxin Man

30 November 2023

Obesity is a chronic metabolic disease that can be induced by a high-fat diet (HFD) and predisposes to a variety of complications. In recent years, various bioactive substances, such as probiotics, prebiotics, and postbiotics, have been widely discus...

  • Article
  • Open Access
1,791 Views
14 Pages

Effect of a Diet-Induced Obesity on the Progeny Response in a Murine Model

  • Maria Gallardo Paffetti,
  • Juan G. Cárcamo,
  • Lucía Azócar-Aedo and
  • Angel Parra

30 November 2023

Diet-induced obesity could have detrimental effects on adults and their progeny. The aim of this study was to determine the effect of a high-energy diet on both F1 mice body weight and tissue/organ weight and F2 offspring growth. A simple murine mode...

  • Review
  • Open Access
31 Citations
23,607 Views
26 Pages

Myths and Facts about Food Intolerance: A Narrative Review

  • Fabiana Zingone,
  • Luisa Bertin,
  • Daria Maniero,
  • Michela Palo,
  • Greta Lorenzon,
  • Brigida Barberio,
  • Carolina Ciacci and
  • Edoardo Vincenzo Savarino

30 November 2023

Most adverse reactions to food are patient self-reported and not based on validated tests but nevertheless lead to dietary restrictions, with patients believing that these restrictions will improve their symptoms and quality of life. We aimed to clar...

  • Article
  • Open Access
1 Citations
2,578 Views
13 Pages

Water Extract of Desalted Salicornia europaea Inhibits RANKL-Induced Osteoclast Differentiation and Prevents Bone Loss in Ovariectomized Mice

  • Ah-Ra Jang,
  • Yun-Ji Lee,
  • Dong-Yeon Kim,
  • Tae-Sung Lee,
  • Do-Hyeon Jung,
  • Yeong-Jun Kim,
  • In-Su Seo,
  • Jae-Hun Ahn,
  • Eun-Jung Song and
  • Jong-Hwan Park
  • + 7 authors

30 November 2023

Osteoporosis, which is often associated with increased osteoclast activity due to menopause or aging, was the main focus of this study. We investigated the inhibitory effects of water extract of desalted Salicornia europaea L. (WSE) on osteoclast dif...

  • Article
  • Open Access
2 Citations
5,367 Views
22 Pages

30 November 2023

Global veganism campaigns like ‘Veganuary’ have gained popularity. We conducted an observational study to assess the impact of a 4-week vegan diet during ‘Veganuary’ on nutrient intake, status, knowledge, and motivations for v...

  • Review
  • Open Access
10 Citations
4,658 Views
26 Pages

The Role of Cdc42 in the Insulin and Leptin Pathways Contributing to the Development of Age-Related Obesity

  • Bauyrzhan Umbayev,
  • Timur Saliev,
  • Yuliya Safarova (Yantsen),
  • Aislu Yermekova,
  • Farkhad Olzhayev,
  • Denis Bulanin,
  • Andrey Tsoy and
  • Sholpan Askarova

29 November 2023

Age-related obesity significantly increases the risk of chronic diseases such as type 2 diabetes, cardiovascular diseases, hypertension, and certain cancers. The insulin–leptin axis is crucial in understanding metabolic disturbances associated...

  • Review
  • Open Access
2 Citations
4,060 Views
37 Pages

A Scoping Review to Explore the Potential Benefits of Nutrition Interventions for Latino/a Adult Cancer Survivors in the US

  • Cassandra M. Johnson,
  • Emily Stubblefield,
  • Brandon M. Godinich,
  • Miranda Walker,
  • Ramona Salcedo Price and
  • Marlyn A. Allicock

29 November 2023

Despite evidence for the role of healthy diets in preventing cancer, little is known about how nutrition can support positive health outcomes after a cancer diagnosis for Latino/a cancer survivors in the United States (U.S.). The purpose of this scop...

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Nutrients - ISSN 2072-6643