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Toxins, Volume 15, Issue 12

December 2023 - 37 articles

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Cover Story: Ascochyta fabae poses a global threat to faba beans. We aimed to explore the potential role of secondary metabolites in symptom development, its ability to produce phytotoxins. Cultured in Czapek-Dox, PDB, and rice substrates, the fungus produced metabolites analyzed using NMR and LC-HRMS methods, revealing seven metabolites varying according to cultural substrates. Phytotoxicity assessments on primary hosts showed that Vicia spp. were particularly susceptible, with faba bean vulnerable to all crude exudates and metabolites, especially at higher concentrations. Notably, ascosalitoxin and benzoic acid exhibited the highest phytotoxicity, suggesting a significant role in necrosis development. View this paper

Articles (37)

  • Article
  • Open Access
2 Citations
2,635 Views
16 Pages

Effects of Harmful Cyanobacteria on Drinking Water Source Quality and Ecosystems

  • Marlena Piontek,
  • Wanda Czyżewska and
  • Hanna Mazur-Marzec

16 December 2023

A seasonal plethora of cyanobacteria in the plankton community can have severe implications, not only for water ecosystems but also for the availability of treated water. The catchment of the Obrzyca River (a source of drinking water) is seasonally e...

  • Article
  • Open Access
4 Citations
2,705 Views
23 Pages

Novel Endophytic Pseudescherichia sp. GSE25 Strain Significantly Controls Fusarium graminearum and Reduces Deoxynivalenol in Wheat

  • Meiling Gao,
  • Mohamed F. Abdallah,
  • Minggui Song,
  • Yiqian Xu,
  • Daiyuan Sun,
  • Ping Lu and
  • Jianhua Wang

15 December 2023

Fusarium heading blight (FHB) is a devastating disease in wheat, primarily caused by field invasion of Fusarium graminearum. Due to the scarcity of resistant wheat varieties, the agricultural sector resorts to chemical fungicides to control FHB incid...

  • Article
  • Open Access
2 Citations
2,584 Views
13 Pages

Cytotoxicity and Radiosensitizing Potentials of Pilosulin-3, a Recombinant Ant Venom, in Breast Cancer Cells

  • Reema M. Alzeer,
  • Khaled S. Al-Hadyan,
  • Najla M. Al-Harbi,
  • Sara S. Bin Judia,
  • Rafa S. Almeer and
  • Ghazi A. Alsbeih

15 December 2023

Venom peptides are promising agents in the development of unconventional anticancer therapeutic agents. This study explored the potential of Pilosulin-3, a recombinant peptide from the venom of the Australian jack jumper ant “Myrmecia pilosula&...

  • Article
  • Open Access
3 Citations
2,272 Views
14 Pages

The Role of α3β1 Integrin Modulation on Fabry Disease Podocyte Injury and Kidney Impairment

  • Bruna Bosquetti,
  • Aline Aparecida Santana,
  • Paulo Cézar Gregório,
  • Regiane Stafim da Cunha,
  • Guilherme Miniskiskosky,
  • Julia Budag,
  • Célia Regina Cavichiolo Franco,
  • Edneia Amancio de Souza Ramos,
  • Fellype Carvalho Barreto and
  • Andréa Emilia Marques Stinghen

14 December 2023

Podocyte dysfunction plays a crucial role in renal injury and is identified as a key contributor to proteinuria in Fabry disease (FD), primarily impacting glomerular filtration function (GFF). The α3β1 integrins are important for podocyte...

  • Review
  • Open Access
5 Citations
4,945 Views
39 Pages

Hosts and Heterologous Expression Strategies of Recombinant Toxins for Therapeutic Purposes

  • Luana di Leandro,
  • Martina Colasante,
  • Giuseppina Pitari and
  • Rodolfo Ippoliti

13 December 2023

The production of therapeutic recombinant toxins requires careful host cell selection. Bacteria, yeast, and mammalian cells are common choices, but no universal solution exists. Achieving the delicate balance in toxin production is crucial due to pot...

  • Article
  • Open Access
3 Citations
2,710 Views
17 Pages

Lake Avernus Has Turned Red: Bioindicator Monitoring Unveils the Secrets of “Gates of Hades”

  • Germana Esposito,
  • Evgenia Glukhov,
  • William H. Gerwick,
  • Gabriele Medio,
  • Roberta Teta,
  • Massimiliano Lega and
  • Valeria Costantino

13 December 2023

Lake Avernus is a volcanic lake located in southern Italy. Since ancient times, it has inspired numerous myths and legends due to the occurrence of singular phenomena, such as coloring events. Only recently has an explanation been found for them, i.e...

  • Article
  • Open Access
3 Citations
4,165 Views
16 Pages

12 December 2023

Botulinum toxin type A (BTX-A) injection is a commonly used therapeutic intervention for upper limb spasticity in stroke patients. This study was designed as a randomized, active-drug-controlled, double-blind, multicenter, phase 3 clinical trial to e...

  • Review
  • Open Access
13 Citations
5,596 Views
20 Pages

Piperine: Chemistry and Biology

  • Jin Han,
  • Shaoyong Zhang,
  • Jun He and
  • Tianze Li

12 December 2023

Piperine is a plant-derived promising piperamide candidate isolated from the black pepper (Piper nigrum L.). In the last few years, this natural botanical product and its derivatives have aroused much attention for their comprehensive biological acti...

  • Review
  • Open Access
5 Citations
3,055 Views
11 Pages

Cellular Uptake and Cytotoxicity of Clostridium perfringens Iota-Toxin

  • Masahiro Nagahama,
  • Masaya Takehara,
  • Soshi Seike and
  • Yoshihiko Sakaguchi

11 December 2023

Clostridium perfringens iota-toxin is composed of two separate proteins: a binding protein (Ib) that recognizes a host cell receptor and promotes the cellular uptake of a catalytic protein and (Ia) possessing ADP-ribosyltransferase activity that indu...

  • Article
  • Open Access
7 Citations
3,433 Views
15 Pages

Bile Acids Promote Hepatic Biotransformation and Excretion of Aflatoxin B1 in Broiler Chickens

  • Liang Chen,
  • Tian Wen,
  • Aizhi Cao,
  • Jianmin Wang,
  • Hua Pan and
  • Ruqian Zhao

9 December 2023

Aflatoxin B1 (AFB1) is a hazardous mycotoxin that often contaminates animal feed and may potentially induce severe liver damage if ingested. The liver is the primary organ responsible for AFB1 detoxification through enzyme-catalyzed xenobiotic metabo...

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