PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation
Abstract
:1. Introduction
The Mechanism of Poly-ADP-Ribosylation and the PARP Superfamily
2. PARylation in Transcription Regulation
2.1. The Major Regulatory Steps of Transcription Activation
2.2. PARP1 Plays a Key Role in the Fine-Tune Regulation of Transcription Initiation
2.3. PARP1 Mediates Promoter-Proximal Pausing and Transcription Elongation
2.4. PARylation Regulates Transcription Responses during DNA Damage
3. PARylation in the Regulation of DNA Damage-Induced Chromatin Structural Changes
4. Role of PARP1 in RNA Metabolism
5. Discussion
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Páhi, Z.G.; Borsos, B.N.; Pantazi, V.; Ujfaludi, Z.; Pankotai, T. PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation. Cancers 2020, 12, 183. https://doi.org/10.3390/cancers12010183
Páhi ZG, Borsos BN, Pantazi V, Ujfaludi Z, Pankotai T. PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation. Cancers. 2020; 12(1):183. https://doi.org/10.3390/cancers12010183
Chicago/Turabian StylePáhi, Zoltán G., Barbara N. Borsos, Vasiliki Pantazi, Zsuzsanna Ujfaludi, and Tibor Pankotai. 2020. "PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation" Cancers 12, no. 1: 183. https://doi.org/10.3390/cancers12010183
APA StylePáhi, Z. G., Borsos, B. N., Pantazi, V., Ujfaludi, Z., & Pankotai, T. (2020). PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation. Cancers, 12(1), 183. https://doi.org/10.3390/cancers12010183