Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance
Abstract
:Simple Summary
Abstract
1. Introduction
2. Stromal Features Can Influence and Predict Outcomes in PDAC
3. Heterotypic Reciprocal Tumor-Stroma Signalling Drives PDAC Development, Progression, and Therapy Resistance
4. Biomechanics Can Regulate PDAC Cell Fate
5. Emerging role of Biomechanics Influencing PDAC Metabolism
6. The Changing Paradigm of Stromal Co-Targeting in PDAC and Future Perspectives
7. Concluding Remarks
Author Contributions
Funding
Conflicts of Interest
References
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Murphy, K.J.; Chambers, C.R.; Herrmann, D.; Timpson, P.; Pereira, B.A. Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance. Cancers 2021, 13, 3481. https://doi.org/10.3390/cancers13143481
Murphy KJ, Chambers CR, Herrmann D, Timpson P, Pereira BA. Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance. Cancers. 2021; 13(14):3481. https://doi.org/10.3390/cancers13143481
Chicago/Turabian StyleMurphy, Kendelle J., Cecilia R. Chambers, David Herrmann, Paul Timpson, and Brooke A. Pereira. 2021. "Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance" Cancers 13, no. 14: 3481. https://doi.org/10.3390/cancers13143481