Revisiting Mitochondria Scored Cancer Progression and Metastasis
Abstract
:Simple Summary
Abstract
1. Good and Bad Mitochondria
2. Can Mitochondrial Dynamics Dictate Cancer Spread?
3. Mitochondria’s Vital Role in Numerous Cancers
4. Multiple Mechanisms of Metastasis by Mitochondria
5. Mitochondrial Stress Response in Cancer Spread
6. Mitochondrial Ion Channels as a Target in Combating Cancer
7. Mitochondria as a Therapeutic Target in Cancers
8. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
OXPHOS | Oxidative phosphorylation |
SNP | Single nucleotide polymorphisms |
EMT | Epithelial mesenchymal transition |
Drp1 | Dynamin-related protein |
Mfn | Mitofusion |
ROS | Reactive oxygen species |
EGFR | Epidermal growth factor receptor |
NSCLC | Non-small cell lung cancer |
AML | Acute myelogenous leukemia |
STUB1 | STIP1 homology and U-Box containing protein 1 |
USP7 | Ubiquitin-specific-processing protease 7 |
PDH | Pyruvate dehydrogenase |
a-KGDH | a-ketoglutarate-dehydrogenase |
Drp1 | Dynamin-related protein-1 |
VDAC | Voltage dependent anion channels |
MFF | Mitochondrial fission factor |
PISD | Phosphatidyl serine decarboxylase |
SIRT | Sirtuin |
PI3K | Phosphatidylinositol-3 kinase |
HNK | Honokiol |
MOM | Mitochondrial outer membrane |
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Target Treatment | Mechanism | Cancers | References |
---|---|---|---|
Phosphatidylinositol-3 kinase (PI3K) | Inhibits mitochondrial transcription and metabolic reprogramming | Lung cancer cell lines | [68] |
Adenomatous Polyposis Coli (APC) protein | Reverses mitochondrial trafficking by regulating Wnt signaling | Colorectal cancer | [77] |
Drp1, Mnf1 | Extends mitochondrial fission | Breast cancer | [8] |
pSer9-GSK-3β; | Suppresses mitochondrial respiratory chain complexes | Breast cancer | [78] |
Mito-TAM (derivative of Tamoxifen) | Disrupts mitochondrial respiratory chain complexes and OXPHOS | Breast cancer | [79] |
PGC-1α | Impairs mitochondrial biogenesis and OXPHOS | shPGC-1α cells | [27] |
Compound | Source | Mode of Action | Cancers |
---|---|---|---|
Honokiol | Magnolia grandifloris | Induces mitochondrial apoptosis | Lung cancer, Breast cancer, Leukemia |
Curcumin | Turmeric | Inducesapoptosis via multiple mechanisms | Skin cancer, Cervical cancer, NSCLC |
Pancratistatin | Spider lily Pancratiumlittorale | Induces ROS stress, loss of mitochondrial potential, apoptosis | Breast cancer, Colon cancer, Lymphoma |
OSW-1 | Ornithogalumsaudersiae | Damages mitochondrial membranes, Ca2+ dependent apoptosis | Leukemia, Malignant brain tumor, Pancreatic cancer |
Epigallocatechin-3-gallate (EGCG) | Green tea | Accumulates in mitochondria, inducing apoptosis | Breast cancer, Colon cancer, Pancreatic cancer, Melanoma |
Vitamin K3 | Synthetic vitamin K precursor | Inhibits mitochondrial pol γ, causing ROS stress | Leukemia and various solid tumors |
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Gundamaraju, R.; Lu, W.; Manikam, R. Revisiting Mitochondria Scored Cancer Progression and Metastasis. Cancers 2021, 13, 432. https://doi.org/10.3390/cancers13030432
Gundamaraju R, Lu W, Manikam R. Revisiting Mitochondria Scored Cancer Progression and Metastasis. Cancers. 2021; 13(3):432. https://doi.org/10.3390/cancers13030432
Chicago/Turabian StyleGundamaraju, Rohit, Wenying Lu, and Rishya Manikam. 2021. "Revisiting Mitochondria Scored Cancer Progression and Metastasis" Cancers 13, no. 3: 432. https://doi.org/10.3390/cancers13030432