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Cancers
Volume 14
Issue 11
10.3390/cancers14112798
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Review
Peer-Review Record

Emerging Therapies for Hepatocellular Carcinoma (HCC)

Cancers 2022, 14(11), 2798; https://doi.org/10.3390/cancers14112798
by Eesha Chakraborty 1 and Devanand Sarkar 2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Cancers 2022, 14(11), 2798; https://doi.org/10.3390/cancers14112798
Submission received: 10 May 2022 / Revised: 31 May 2022 / Accepted: 2 June 2022 / Published: 4 June 2022
(This article belongs to the Collection Advances in the Management of Hepatocellular Carcinoma)

Round 1

Reviewer 1 Report

Dr. Eesha Chakraborty and Dr. Devanand Sarkar reported their review related to developing new and advanced therapies for patients with hepatocellular carcinoma (HCC). They comprehensively reviewed many articles related to gene therapy and immunotherapy in ongoing trials or pre-clinical trials. The review is well-written and very informative for researchers related to developing new therapies for HCC. 

Author Response

We thank the reviewer for finding the manuscript well-written and comprehensive.

Reviewer 2 Report

I enjoyed reviewing this interesting manuscript. The paper is up to date and well written. The topic is certainly hot. The figures are clear.

This reviewer only suggests enriching the text with an issue that has not been addressed by the authors.

 

Sustained viral response (SVR) of HCV by DAAs leads to a significant reduction of incidence of HCC (J Transl Med. 2019 Aug 28;17(1):292. doi: 10.1186/s12967-019-2033-x. - Cancers (Basel). 2020 May 26;12(6):1351. doi: 10.3390/cancers12061351. - J Viral Hepat. 2021 Sep 28. doi: 10.1111/jvh.13617. - Dig Dis Sci. 2019 Oct;64(10):3013-3019. doi: 10.1007/s10620-019-05604-8.). This issue with the above references should be added as well as commented to underline the importance of sustained clearance of HCV by DAAs on risk of HCC.

Author Response

We thank the reviewer for finding our manuscript well-written and up to date. As suggested by the reviewer we have included 2 new references, reference # 1 and 2. As such all other references are changed accordingly.

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