HSPG2 Mutation Association with Immune Checkpoint Inhibitor Outcome in Melanoma and Non-Small Cell Lung Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Samples Used in This Study
2.2. Mutational Signatures in the Genome
2.3. Tumor-Infiltrating Immune Cells
2.4. Immune Infiltration and Immunogenicity-Related Signatures
2.5. GSVA and GSEA
2.6. TMB and NB
2.7. Statistical Analysis
3. Results
3.1. HSPG2 Mutations of Melanoma
3.2. HSPG2 Mutations Associated with Melanoma ICI Outcome
3.3. Connection of HSPG2 Mutations with Mutational Burden in Melanoma
3.4. Validation in NSCLC
3.5. Immunologic Features behind HSPG2 Mutations
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Zhang, W.; Lin, Z.; Shi, F.; Wang, Q.; Kong, Y.; Ren, Y.; Lyu, J.; Sheng, C.; Li, Y.; Qin, H.; et al. HSPG2 Mutation Association with Immune Checkpoint Inhibitor Outcome in Melanoma and Non-Small Cell Lung Cancer. Cancers 2022, 14, 3495. https://doi.org/10.3390/cancers14143495
Zhang W, Lin Z, Shi F, Wang Q, Kong Y, Ren Y, Lyu J, Sheng C, Li Y, Qin H, et al. HSPG2 Mutation Association with Immune Checkpoint Inhibitor Outcome in Melanoma and Non-Small Cell Lung Cancer. Cancers. 2022; 14(14):3495. https://doi.org/10.3390/cancers14143495
Chicago/Turabian StyleZhang, Wenjing, Zhijuan Lin, Fuyan Shi, Qiang Wang, Yujia Kong, Yanfeng Ren, Juncheng Lyu, Chao Sheng, Yuting Li, Hao Qin, and et al. 2022. "HSPG2 Mutation Association with Immune Checkpoint Inhibitor Outcome in Melanoma and Non-Small Cell Lung Cancer" Cancers 14, no. 14: 3495. https://doi.org/10.3390/cancers14143495