The Central Role of the Ubiquitin–Proteasome System in EBV-Mediated Oncogenesis
Abstract
:Simple Summary
Abstract
1. Introduction
2. EBV Latent Antigens Manipulate the Ubiquitin–Proteasome System for Targeted Protein Degradation
3. EBV Lytic Antigens Modulate the Activities of the Ubiquitin–Proteasome System for Protein Degradation
4. EBV-Encoded Proteins Can Be Modified by the Ubiquitin–Proteasome System
5. Targeting EBV-Associated Oncogenesis with Proteasome Inhibitors
6. Conclusions and Perspectives
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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EBV Life Cycle | EBV Antigens | Cellular Factors |
---|---|---|
Latent cycle | EBNA1 | USP7 CK2 PRMT5 |
EBNA3C | Bcl6 Cyclin D1 Cyclin D2 Skp2 Pim-1 | |
LMP1 | RIPK1 RIPK3 P53 TRAF1 TRAF6 NF-κB2 p100 RNF31 IRF7 CHIP TRAFD1 | |
LMP2A | AIP4 WWP2 Nedd4 Siah-1 | |
Lytic cycle | Rta | TRIM5α |
BDLF3 | MHC-I MHC-II | |
BPLF1 | P62 TOP2 TRIM25 PCNA Rad18 RR | |
BGLF2 | Cullin 1 TYK2 |
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Pei, Y.; Robertson, E.S. The Central Role of the Ubiquitin–Proteasome System in EBV-Mediated Oncogenesis. Cancers 2022, 14, 611. https://doi.org/10.3390/cancers14030611
Pei Y, Robertson ES. The Central Role of the Ubiquitin–Proteasome System in EBV-Mediated Oncogenesis. Cancers. 2022; 14(3):611. https://doi.org/10.3390/cancers14030611
Chicago/Turabian StylePei, Yonggang, and Erle S. Robertson. 2022. "The Central Role of the Ubiquitin–Proteasome System in EBV-Mediated Oncogenesis" Cancers 14, no. 3: 611. https://doi.org/10.3390/cancers14030611