Three-Year Analysis of Adjuvant Therapy in Postoperative Melanoma including Acral and Mucosal Subtypes
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Ethics
2.2. Patients
2.3. Procedure
2.4. Assessment
2.5. Statistical Analysis
3. Results
3.1. Demographic Data
3.2. Three-Year TTR in Subtypes of Melanoma
3.3. Three-Year OS in Subtypes of Melanoma
3.4. Multivariate Analysis of the Prognostic Factors in Both TTR and OS
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameters | Hazard Ratio (95% CI) | p Value |
---|---|---|
Histological characteristics | ||
Non-acral cutaneous vs. acral types | 0.28 (0.14–0.59) | 0.0007 * |
Tumor thickness | 0.32 (0.16–0.66) | 0.0020 * |
Tumor ulceration | 0.83 (0.40–1.7) | 0.61 |
BRAF wild vs. mutated type | 0.44 (0.12–1.6) | 0.21 |
Baseline characteristics | ||
Sex | 0.65 (0.34–1.3) | 0.2 |
With or Without lymph node dissection | 0.77 (0.40–1.5) | 0.45 |
Parameters | Hazard Ratio (95% CI) | p Value |
---|---|---|
Histological characteristics | ||
Non-acral cutaneous vs. acral types | 0.95 (0.38–2.33) | 0.9 |
Tumor thickness | 0.83 (0.32–2.2) | 0.71 |
Tumor ulceration | 0.30 (0.095–0.97) | 0.044 * |
BRAF wild vs. mutated type | NA | 0.99 |
Baseline characteristics | ||
Sex | 0.72 (0.28–1.9) | 0.5 |
With or Without lymph node dissection | 0.77 (0.40–1.5) | 0.45 |
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Muto, Y.; Kambayashi, Y.; Kato, H.; Mizuhashi, S.; Ito, T.; Maekawa, T.; Ishizuki, S.; Uchi, H.; Matsushita, S.; Yamamoto, Y.; et al. Three-Year Analysis of Adjuvant Therapy in Postoperative Melanoma including Acral and Mucosal Subtypes. Cancers 2024, 16, 2755. https://doi.org/10.3390/cancers16152755
Muto Y, Kambayashi Y, Kato H, Mizuhashi S, Ito T, Maekawa T, Ishizuki S, Uchi H, Matsushita S, Yamamoto Y, et al. Three-Year Analysis of Adjuvant Therapy in Postoperative Melanoma including Acral and Mucosal Subtypes. Cancers. 2024; 16(15):2755. https://doi.org/10.3390/cancers16152755
Chicago/Turabian StyleMuto, Yusuke, Yumi Kambayashi, Hiroshi Kato, Satoru Mizuhashi, Takamichi Ito, Takeo Maekawa, Shoichiro Ishizuki, Hiroshi Uchi, Shigeto Matsushita, Yuki Yamamoto, and et al. 2024. "Three-Year Analysis of Adjuvant Therapy in Postoperative Melanoma including Acral and Mucosal Subtypes" Cancers 16, no. 15: 2755. https://doi.org/10.3390/cancers16152755