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Cells, Volume 11, Issue 21

November-1 2022 - 194 articles

Cover Story: To investigate cellular and molecular changes in hPSC-derived developing early retinal organoids, we generated SIX6-GFP and VSX2-tdTomato (or VSX2-h2b-mRuby3) dual fluorescent reporters. These 3D organoids expressed GFP at day 15 and tdTomato (or mRuby3) at day 25, respectively. This enabled us to explore transcriptional- and chromatin-related changes using RNA-seq and ATAC-seq, from pluripotency through to early retina specification. Correlating gene transcription with chromatin accessibility in early eye field development showed that retinal cells underwent a clear change in the chromatin landscape, as well as gene expression profiles. Pathway analysis revealed a stepwise loss of pluripotency, while optic vesicle and retina pathways became progressively more prevalent. Considering both datasets in parallel provided an informative glimpse into the molecular nature of eye development. View this paper
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Articles (194)

  • Review
  • Open Access
7 Citations
4,508 Views
22 Pages

7 November 2022

Gaining structural information is a must to allow the unequivocal structural characterization of analytes from natural sources. In liquid state, NMR spectroscopy is almost the only possible alternative to HPLC-MS and hyphenating the effluent of an an...

  • Review
  • Open Access
19 Citations
4,185 Views
13 Pages

The Versatile Role of miR-21 in Renal Homeostasis and Diseases

  • Romain Larrue,
  • Sandy Fellah,
  • Cynthia Van der Hauwaert,
  • Marie-Flore Hennino,
  • Michaël Perrais,
  • Arnaud Lionet,
  • François Glowacki,
  • Nicolas Pottier and
  • Christelle Cauffiez

7 November 2022

MicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases hav...

  • Article
  • Open Access
5 Citations
3,238 Views
18 Pages

The Protective Effects of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Noise-Induced Hearing Loss of Rats

  • So Young Kim,
  • Jeoung Eun Lee,
  • Sung Hun Kang,
  • So Min Lee,
  • Jiwon Jeon and
  • Dong Ryul Lee

7 November 2022

A few prior animal studies have suggested the transplantation or protective effects of mesenchymal stem cells (MSCs) in noise-induced hearing loss. This study intended to evaluate the fates of administered MSCs in the inner ears and the otoprotective...

  • Article
  • Open Access
37 Citations
8,293 Views
27 Pages

Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive Deficits

  • Md Abu Bakkar Siddik,
  • Caitlyn A. Mullins,
  • Alyssa Kramer,
  • Harsh Shah,
  • Ritchel B. Gannaban,
  • Masoud Zabet-Moghaddam,
  • Ryan M. Huebinger,
  • Vijay K. Hegde,
  • Sheba M. J. MohanKumar and
  • Puliyur S. MohanKumar
  • + 1 author

7 November 2022

Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder with a complex pathophysiology. Type 2 diabetes (T2D) is a strong risk factor for AD that shares similar abnormal features including metabolic dysregulation and brain pathol...

  • Article
  • Open Access
3 Citations
3,183 Views
18 Pages

Premature Macrophage Activation by Stored Red Blood Cell Transfusion Halts Liver Regeneration Post-Partial Hepatectomy in Rats

  • Nathalie Abudi,
  • Omri Duev,
  • Tal Asraf,
  • Simcha Blank,
  • Idit Matot and
  • Rinat Abramovitch

7 November 2022

Liver resection is a common treatment for various conditions and often requires blood transfusions to compensate for operative blood loss. As partial hepatectomy (PHx) is frequently performed in patients with a pre-damaged liver, avoiding further inj...

  • Review
  • Open Access
29 Citations
6,776 Views
22 Pages

Neutrophil Extracellular Traps in Asthma: Friends or Foes?

  • Remo Poto,
  • Mohamed Shamji,
  • Gianni Marone,
  • Stephen R. Durham,
  • Guy W. Scadding and
  • Gilda Varricchi

7 November 2022

Asthma is a chronic inflammatory disease characterized by variable airflow limitation and airway hyperresponsiveness. A plethora of immune and structural cells are involved in asthma pathogenesis. The roles of neutrophils and their mediators in diffe...

  • Article
  • Open Access
11 Citations
2,758 Views
15 Pages

7 November 2022

The metabolism disorders are a common convergence of Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM). The characteristics of AD are senile plaques and neurofibrillary tangles (NFTs) composed by deposits of amyloid−β (A&b...

  • Article
  • Open Access
17 Citations
3,176 Views
14 Pages

7 November 2022

Mastitis is characterized by inflammatory damage to mammary gland tissue, which could decline milk production and quality and significantly affect the economic benefits of ranching. MicroRNAs (miRNAs), such as miR-199a-3p, are novel therapeutic targe...

  • Article
  • Open Access
7 Citations
3,327 Views
16 Pages

Dynamic Balance between PTH1R-Dependent Signal Cascades Determines Its Pro- or Anti-Osteogenic Effects on MSC

  • Konstantin Kulebyakin,
  • Pyotr Tyurin-Kuzmin,
  • Leila Sozaeva,
  • Nikita Voloshin,
  • Mikhail Nikolaev,
  • Vadim Chechekhin,
  • Maxim Vigovskiy,
  • Veronika Sysoeva,
  • Elizaveta Korchagina and
  • Daria Naida
  • + 1 author

7 November 2022

Parathyroid hormone (PTH) is one of the key regulators of calcium and phosphate metabolism in the body, controlling bone metabolism and ion excretion by the kidneys. At present, attempts to use PTH as a therapeutic agent have been associated with sid...

  • Article
  • Open Access
4 Citations
2,724 Views
16 Pages

7 November 2022

To ensure proper wound healing it is important to elucidate the signaling cues that coordinate leader and follower cell behavior to promote collective migration and proliferation for wound healing in response to injury. Using an ex vivo post-cataract...

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Cells - ISSN 2073-4409