Next Article in Journal
Using High-Definition Transcranial Alternating Current Stimulation to Treat Patients with Fibromyalgia: A Randomized Double-Blinded Controlled Study
Next Article in Special Issue
A Pathophysiological Approach to Reduce Peritumoral Edema with Gamma Knife Radiosurgery for Large Incidental Meningiomas
Previous Article in Journal
Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition
Previous Article in Special Issue
Gamma Knife Radiosurgery for Indirect Dural Carotid–Cavernous Fistula: Long-Term Ophthalmological Outcome
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Life
Volume 12
Issue 9
10.3390/life12091363
Review Report
life-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Prognostic Factors Analysis for Intracranial Cavernous Malformations Treated with Linear Accelerator Stereotactic Radiosurgery

Life 2022, 12(9), 1363; https://doi.org/10.3390/life12091363
by Meng-Wu Chung 1, Chi-Cheng Chuang 1, Chun-Chieh Wang 2, Hsien-Chih Chen 3 and Peng-Wei Hsu 1,*
Reviewer 1:
Chanon Ngamsombat
Reviewer 2:
Mirjam Gerwing
Life 2022, 12(9), 1363; https://doi.org/10.3390/life12091363
Submission received: 9 August 2022 / Revised: 26 August 2022 / Accepted: 29 August 2022 / Published: 31 August 2022
(This article belongs to the Special Issue Development and Use of Photon Knife in Intracranial Disease)

Round 1

Reviewer 1 Report

The introduction is appropriate, the methodology is exhaustive, and the results are well-presented. The discussion is adequate.

I think the font size of the text in figures 1, 4, 5, 9 and 10 are too small to read.

The references are current.

Overall, the manuscript is well-written.

Author Response

Thanks for your review and advice. Our reply was presented in the word file. 

Author Response File: Author Response.doc

Reviewer 2 Report

The authors analyzed 30 patients with cranial cavernous malformations treated with linear accelerator stereotactic radio surgery in a single center. 

The analysis of risk factors and outcome predictors based on clinical and imaging data is straight forward and provides information for clinical practice that can be validated in a larger study. 

There are some improvements that should be made before publication, in detail:

-       Line 33: add “primary objective of treatment”

-       Figure 1: please enlarge the histogram

-       Please give a short overview over the used MRI protocol and the system (1.5 T?)

-       Line 105: please use consistent terms, tumor could be misleading here

-       Were patients treated with LINAC SRS after interdisciplinary board discussion? Please add a short explanation on the algorithm used in your center 

-       Could you please comment on the long average time between bleeding event and treatment?

-       Figure 2: please use the T2 image for D as well 

-       Figure 4 & 5 & 9 & 10 are hardly readable, please increase quality and size of the tables

-       Figure 8: use FLAIR image for B as well

-       Please add an explanation for dose finding for the individual patient at your clinic, did you now switch to >1600cGy in clinical routine?

-       Paragraph 4.6: you have not compared this in the presented study, this needs to be clearer differentiated and discussed in more detail

Author Response

Thanks for your review and advice. Please see the attachment for our reply.

Author Response File: Author Response.doc

Back to TopTop