Next Article in Journal
Hepatitis B Core-Related Antigen as Surrogate Biomarker of Intrahepatic Hepatitis B Virus Covalently-Closed-Circular DNA in Patients with Chronic Hepatitis B: A Meta-Analysis
Next Article in Special Issue
Impact of Lymphovascular Invasion on Prognosis in the Patients with Bladder Cancer—Comparison of Transurethral Resection and Radical Cystectomy
Previous Article in Journal
Renal Tumors with Oncocytic and Papillary Features: A Phenotypic and Genotypic Study
Previous Article in Special Issue
Soluble Syndecan-1 Levels Are Associated with Survival in Platinum-Treated Bladder Cancer Patients
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Diagnostics
Volume 11
Issue 2
10.3390/diagnostics11020185
diagnostics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Photodynamic Diagnosis-Assisted Transurethral Resection Using Oral 5-Aminolevulinic Acid Decreases the Risk of Repeated Recurrence in Non-Muscle-Invasive Bladder Cancer: A Cumulative Incidence Analysis by the Person-Time Method

by
Makito Miyake
1,*,†,
Nobutaka Nishimura
1,†,
Yasushi Nakai
1,
Tomomi Fujii
2,
Takuya Owari
1,
Shunta Hori
1,
Yosuke Morizawa
1,
Daisuke Gotoh
1,
Satoshi Anai
1,
Kazumasa Torimoto
1,
Nobumichi Tanaka
3,
Yoshihiko Hirao
4 and
Kiyohide Fujimoto
1,*
1
Department of Urology, Nara Medical University, Kashihara, Nara 634-8522, Japan
2
Department of Diagnostic Pathology, Nara Medical University, Kashihara, Nara 634-8522, Japan
3
Department of Prostate Brachytherapy Nara Medical University, Kashihara, Nara 634-8522, Japan
4
Department of Urology, Osaka Gyoumeikan Hospital, Konohana-ku, Osaka 554-0012, Japan
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this paper.
Diagnostics 2021, 11(2), 185; https://doi.org/10.3390/diagnostics11020185
Submission received: 1 January 2021 / Revised: 20 January 2021 / Accepted: 26 January 2021 / Published: 28 January 2021
(This article belongs to the Special Issue Early Detection, Diagnosis, and Management of Bladder Cancer – Importance of Biomarkers)
Browse Figures
Versions Notes

Abstract

Clinical evidence regarding risk reduction of repeated bladder recurrence after initial photodynamic diagnosis (PDD)-assisted transurethral resection of bladder tumor (TURBT) is still limited in patients with non-muscle-invasive bladder cancer (NMIBC). We analyzed patients with primary NMIBC undergoing TURBT without any adjuvant treatment to compare the risk of cumulative recurrence between the conventional white-light (WL)-TURBT and PDD-TURBT. Out of 430 patients diagnosed with primary NMIBC from 2010 to 2019, 40 undergoing WL-TURBT and 60 undergoing PDD-TURBT were eligible. Multivariate Cox regression analysis for time to the first recurrence demonstrated that PDD assistance was an independent prognostic factor with better outcome (p = 0.038, hazard ratio = 0.39, and 95% confidence interval 0.16–0.95). While no patient experienced more than one recurrence within 1000 postoperative days in the PDD-TURBT group, five out of 40 patients treated by WL-TURBT experienced repeated recurrence. The comparison of cumulative incidence per 10,000 person-days between the two groups revealed that PDD assistance decreased by 6.6 recurrences per 10,000 person-days (exact p = 0.011; incidence rate ratio 0.37, Clopper–Pearson confidence interval 0.15–0.82). This is the first study addressing PDD assistance-induced risk reduction of repeated bladder recurrence using the person-time method. Our findings could support clinical decision making, especially on adjuvant therapy after TURBT.
Keywords: bladder cancer; urothelial carcinoma; transurethral resection; fluorescence; photodynamic diagnosis; 5-aminolevulinic acid; repeated recurrence; prognosis; person-time method bladder cancer; urothelial carcinoma; transurethral resection; fluorescence; photodynamic diagnosis; 5-aminolevulinic acid; repeated recurrence; prognosis; person-time method

Share and Cite

MDPI and ACS Style

Miyake, M.; Nishimura, N.; Nakai, Y.; Fujii, T.; Owari, T.; Hori, S.; Morizawa, Y.; Gotoh, D.; Anai, S.; Torimoto, K.; et al. Photodynamic Diagnosis-Assisted Transurethral Resection Using Oral 5-Aminolevulinic Acid Decreases the Risk of Repeated Recurrence in Non-Muscle-Invasive Bladder Cancer: A Cumulative Incidence Analysis by the Person-Time Method. Diagnostics 2021, 11, 185. https://doi.org/10.3390/diagnostics11020185

AMA Style

Miyake M, Nishimura N, Nakai Y, Fujii T, Owari T, Hori S, Morizawa Y, Gotoh D, Anai S, Torimoto K, et al. Photodynamic Diagnosis-Assisted Transurethral Resection Using Oral 5-Aminolevulinic Acid Decreases the Risk of Repeated Recurrence in Non-Muscle-Invasive Bladder Cancer: A Cumulative Incidence Analysis by the Person-Time Method. Diagnostics. 2021; 11(2):185. https://doi.org/10.3390/diagnostics11020185

Chicago/Turabian Style

Miyake, Makito, Nobutaka Nishimura, Yasushi Nakai, Tomomi Fujii, Takuya Owari, Shunta Hori, Yosuke Morizawa, Daisuke Gotoh, Satoshi Anai, Kazumasa Torimoto, and et al. 2021. "Photodynamic Diagnosis-Assisted Transurethral Resection Using Oral 5-Aminolevulinic Acid Decreases the Risk of Repeated Recurrence in Non-Muscle-Invasive Bladder Cancer: A Cumulative Incidence Analysis by the Person-Time Method" Diagnostics 11, no. 2: 185. https://doi.org/10.3390/diagnostics11020185

APA Style

Miyake, M., Nishimura, N., Nakai, Y., Fujii, T., Owari, T., Hori, S., Morizawa, Y., Gotoh, D., Anai, S., Torimoto, K., Tanaka, N., Hirao, Y., & Fujimoto, K. (2021). Photodynamic Diagnosis-Assisted Transurethral Resection Using Oral 5-Aminolevulinic Acid Decreases the Risk of Repeated Recurrence in Non-Muscle-Invasive Bladder Cancer: A Cumulative Incidence Analysis by the Person-Time Method. Diagnostics, 11(2), 185. https://doi.org/10.3390/diagnostics11020185

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop