Early Detection, Diagnosis, and Management of Bladder Cancer – Importance of Biomarkers
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 20417
Special Issue Editors
Interests: urinary biomarkers; early detection; prognostics; prediction of the response to treatment; bladder cancer; the role of sphingolipid signaling cascade in cancers
Special Issues, Collections and Topics in MDPI journals
Interests: molecular diagnostics and experimental therapeutics; specifically bladder cancer biomarkers for early detection, clinical diagnosis and prognosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Despite improvements in the diagnosis and treatment of bladder cancer, the death rates of bladder cancer have been increasing over the past two decades. In addition, bladder cancer has one of the highest recurrence rates of any tumor type. Although treatment, such as administration of intravesical immunologic or chemotherapeutic agents, helps lower the risk of recurrence, the risk still remains 31%–78% after 5 years. Unfortunately, up to 45% of non-muscle invasive bladder cancer (NMIBC) progresses to muscle invasive bladder cancer (MIBC) after 5 years, leading to dismal survival rates associated with more advance disease. When diagnosed early as NMIBC, including stage 0 or I, a cure with surgical resection is possible in a high percentage of cases: a 5-year survival rate of 98% and 88%, respectively. However, once it becomes MIBC or metastatic including stage II, III, and IV, it is fatal, with an estimated 5-year survival rate of 63%, 46%, and 15%, respectively. Thus, there is an urgent need to develop novel strategies for prevention and treatment of bladder cancer. The forthcoming Special Issue will welcome submissions on, but not limited to, the following topics:
- Risk factors (epidemiological and biological factors including the mechanism);
- Non-invasive detection biomarkers, such as blood- and urine-based biomarkers;
- Novel DNA, RNA, and protein biomarkers;
- Extracellular vesicles;
- Precision medicine;
- Immunotherapy including immune checkpoint inhibitors;
- Predictive biomarkers.
Dr. Hideki Furuya
Dr. Charles Rosser
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Personalized medicine
- Molecular diagnosis
- Biomarkers (early detection, grading, staging, prognosis, prediction of response to chemo- and immuno-therapies)
- Novel therapies (gene, cell, and molecular therapy)
- Genotype-phenotype correlation and modifier genes
- Preclinical models (cell and tissue, organoids, animal models)
- OMICS
- Immunotherapy
- Targeted therapy