Central Nervous System Involvement in Primary Sjögren’s Syndrome: Narrative Review of MRI Findings
, Zsófia Aradi 2, Ildikó Fanny Horváth 2, János Bencze 3, Tamás Papp 3, Miklós Emri 4, Ervin Berényi 3, Antal Bugán 1 and Antónia Szántó 2Round 1
Reviewer 1 Report
The group of investigating patients is not appropriate defined; age, duration of disease and presence of certain type of specific antibodies???
The distinction to Multiple sclerosis is not enough stressed.
Author Response
Please see the attachment.
Author Response File: 
Author Response.docx
Reviewer 2 Report
The authors did a systematic review on brain MRI findings in primary Sjögren's syndrome (pSS). The topic is interesting and of much interest because neurological symptoms are a very common manifestation of pSS, and the idea that autoimmune diseases of a particular system only affect it has long been abandoned.
However the paper is fairly written and provides a good analysis of the results it has some inaccuracies that should be corrected before publication:
1. what was the methodology of the work? what were the rules for searching for articles? The authors should provide an analysis of qualified/disqualified articles, e.g., using a flow-chart or descriptively. We do not know what keywords were used to find relevant literature.
2. in the discussion, it is worth discussing some studies suggesting brain bioelectrical dysfunction in pSS patients without nervous system damage measured by evoked potentials based on:
https://pubmed.ncbi.nlm.nih.gov/29850640/
https://pubmed.ncbi.nlm.nih.gov/32809145/
these studies may confirm the discussed functional impairment in pSS
Author Response
Please see the attachment.
Author Response File: Author Response.docx
