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Microorganisms
Volume 10
Issue 3
10.3390/microorganisms10030490
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Review
Peer-Review Record

Gut Microbiota, Macrophages and Diet: An Intriguing New Triangle in Intestinal Fibrosis

Microorganisms 2022, 10(3), 490; https://doi.org/10.3390/microorganisms10030490
by Asma Amamou 1,*, Cian O’Mahony 1, Mathilde Leboutte 2, Guillaume Savoye 3, Subrata Ghosh 1 and Rachel Marion-Letellier 2
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Microorganisms 2022, 10(3), 490; https://doi.org/10.3390/microorganisms10030490
Submission received: 1 February 2022 / Revised: 18 February 2022 / Accepted: 21 February 2022 / Published: 22 February 2022
(This article belongs to the Special Issue Involvement of the Gut Microbiome in Inflammatory Bowel Disease)

Round 1

Reviewer 1 Report

Dear Authors,

After the review process, I have several comments: you should present in the figures legend how was realized; in pages 8 and 9, you should include new data about the significance of vitamins in human well being, e.g. the role of vitamins in neurodegenerative disease, pathologies strictly related with the microbiota dysbiosis; in page 6, the relation between diet and microbiota fingerprint should be expanded, based on the link between obesity, microbiota dysbiosis, and neurodegenerative pathogenesis.

Best regards.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Amamou et al discussed an important topic  about the link of Gut microbiota, macrophages, and diet in intestinal fibrosis. The authors focused on the following points: a) Macrophages as key player in fibrogenesis.  b) Factors that influence macrophage polarization in inflammation and fibrosis: including the Gut microbiota and diet. 

c) Interplay between diet, gut microbiota and macrophages in intestinal fibrosis.   d) Reprogramming macrophages for treatment of fibrosis: the future directions.

The review is well written and has a good flow. I have some suggestions to improve the quality of the manuscript

1) The cross talk between gut epithelium and macrophage during infection and how this interaction affect intestinal inflammation which is the first step toward the fibrogenesis. This point is missing and it should be included in the review.

2) The role of adaptive immune response especially T -lymphocyte is also missing

3) Therapies that affect gut epithelium and could reduce the risk of IBD and/or its complications.

4) In Diet section, may be the authors mention some probiotics, prebiotics that can be used to manage the IBD.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

The authors addressed my suggestions and the manuscript is improved significantly.

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