The Human Mycobiome in Chronic Respiratory Diseases: Current Situation and Future Perspectives

Round 1

Reviewer 1 Report

The manuscript covers an interesting topic. It is well written, however no methodological section is provided. Please, add information on how the review has been conducted. 

Please, specify in the title that it is a review, also specify what type of review

Please, add a figure regarding the section 3 "Studying the human mycobiome by Next-Generation Sequencing"

Also, plwasw considwe to add a graphical abstract. The content of the manuscript is interesting but not easy to follow. Adding tables and figures may improve the readability. 

Author Response

Dear reviewer

The authors would like to thank you for your review work and your positive comments which have helped to improved the article. Now, I will try to answer to your comments point-by-point:

The manuscript covers an interesting topic. It is well written, however no methodological section is provided. Please, add information on how the review has been conducted. 

We respectfully feel that a methodological section is not necessary in this type of work, as it is a literature review and not a systematic review. This work has been made by experts in different clinical and laboratory fields, who have included the literature that they considered to be most relevant. After reviewing similar papers submitted to this journal, we have not found a methodological section in any of them. We, therefore, have decided not to add this section in this work.

Please, specify in the title that it is a review, also specify what type of review

Again, respectfully, we think it is not necessary to specify this in the title, as it is already specified in the journal's template. In our opinion, it would lengthen the title without providing any relevant information.

Please, add a figure regarding the section 3 "Studying the human mycobiome by Next-Generation Sequencing"

We have added a new figure (Figure 1), in which we have summarised the workflow for the analysis of respiratory samples by NGS.

Also, please consider to add a graphical abstract. The content of the manuscript is interesting but not easy to follow. Adding tables and figures may improve the readability. 

We think the graphical abstract is a good idea and we have made one to include in the pubblication.

Reviewer 2 Report

This work is well conducted, it does significantly summarize the research around human mycobiome in chronic respiratory diseases.

I recommend the acceptance of the manuscript after language corrections.

Author Response

Dear reviewer

The authors would like to thank you for your review work and your comments, which have served to improve the article. We have sent the paper to a scientific English reviewer and have made the corrections suggested by him.

Round 2

Reviewer 1 Report

thank you for the efforts in improving the manuscript