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Review

New Approaches to Tackling Intractable Issues in Infectious Disease

by
Paul Barrow
School of Veterinary Medicine, University of Surrey, Daphne Jackson Road, Guildford, Surrey GU2 7AL, UK
Microorganisms 2024, 12(3), 421; https://doi.org/10.3390/microorganisms12030421
Submission received: 2 November 2023 / Revised: 28 December 2023 / Accepted: 29 December 2023 / Published: 20 February 2024
(This article belongs to the Special Issue Latest Review Papers in Veterinary Microbiology 2023)

Abstract

Despite major progress in the last several decades in reducing the public and animal health burden of infectious disease a number of issues remain to be resolved and which have thus far been regarded as intractable. These include (i) the persistent carrier state in individuals convalescent from typhoid and typhoid-like infections, (ii) the increasing prevalence of multi-antibiotic resistance in enteric pathogens, much of which is mediated by self-transmissible plasmids, and (iii) parasite infections which are difficult to control by vaccination and where resistance to chemotherapeutics is also increasing. The author describes very recent work carried out by his group to look at resolving these problems in new and imaginative ways.
Keywords: Salmonella; carriage; immune modulation; antimicrobial resistance; AMR; bacteriophages; plasmids; viruses; parasites Salmonella; carriage; immune modulation; antimicrobial resistance; AMR; bacteriophages; plasmids; viruses; parasites

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MDPI and ACS Style

Barrow, P. New Approaches to Tackling Intractable Issues in Infectious Disease. Microorganisms 2024, 12, 421. https://doi.org/10.3390/microorganisms12030421

AMA Style

Barrow P. New Approaches to Tackling Intractable Issues in Infectious Disease. Microorganisms. 2024; 12(3):421. https://doi.org/10.3390/microorganisms12030421

Chicago/Turabian Style

Barrow, Paul. 2024. "New Approaches to Tackling Intractable Issues in Infectious Disease" Microorganisms 12, no. 3: 421. https://doi.org/10.3390/microorganisms12030421

APA Style

Barrow, P. (2024). New Approaches to Tackling Intractable Issues in Infectious Disease. Microorganisms, 12(3), 421. https://doi.org/10.3390/microorganisms12030421

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