Next Article in Journal
Exploring the Role of the Microbiome in Rheumatoid Arthritis—A Critical Review
Previous Article in Journal
Recruitment of Vitronectin by Bacterial Pathogens: A Comprehensive Overview
Previous Article in Special Issue
AG1®, a Novel Synbiotic, Maintains Gut Barrier Function following Inflammatory Challenge in a Caco-2/THP1-Blue™ Co-Culture Model
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

The Relationship between Exposome and Microbiome

1
Department of Biomedicine and Prevention, Section of Clinical Nutrition and Nutrigenomics, University of Rome Tor Vergata, 00133 Rome, Italy
2
Ph.D. School of Applied Medical-Surgical-Sciences, Univeristy of Rome Tor Vergata, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Microorganisms 2024, 12(7), 1386; https://doi.org/10.3390/microorganisms12071386
Submission received: 25 June 2024 / Revised: 2 July 2024 / Accepted: 6 July 2024 / Published: 8 July 2024
(This article belongs to the Special Issue Intestinal Dysbiosis)

Abstract

Currently, exposome studies include a raft of different monitoring tools, including remote sensors, smartphones, omics analyses, distributed lag models, etc. The similarity in structure between the exposome and the microbiota plus their functions led us to pose three pertinent questions from this viewpoint, looking at the actual relationship between the exposome and the microbiota. In terms of the exposome, a bistable equilibrium between health and disease depends on constantly dealing with an ever-changing totality of exposures that together shape an individual from conception to death. Regarding scientific knowledge, the exposome is still lagging in certain areas, like the importance of microorganisms in the equation. The human microbiome is defined as an aggregate assemblage of gut commensals that are hosted by our surfaces related to the external environment. Commensals’ resistance to a variety of environmental exposures, such as antibiotic administration, confirms that a layer of these organisms is protected within the host. The exposome is a conceptual framework defined as the environmental component of the science-inspired systems ideology that shifts from a specificity-based medical approach to reasoning in terms of complexity. A parallel concept in population health research and precision public health is the human flourishing index, which aims to account for the numerous environmental factors that affect individual and population well-being beyond ambient pollution.
Keywords: microbiome; exposome; omics; commensals; organisms; environmental microbiome; exposome; omics; commensals; organisms; environmental

Share and Cite

MDPI and ACS Style

Merra, G.; Gualtieri, P.; La Placa, G.; Frank, G.; Della Morte, D.; De Lorenzo, A.; Di Renzo, L. The Relationship between Exposome and Microbiome. Microorganisms 2024, 12, 1386. https://doi.org/10.3390/microorganisms12071386

AMA Style

Merra G, Gualtieri P, La Placa G, Frank G, Della Morte D, De Lorenzo A, Di Renzo L. The Relationship between Exposome and Microbiome. Microorganisms. 2024; 12(7):1386. https://doi.org/10.3390/microorganisms12071386

Chicago/Turabian Style

Merra, Giuseppe, Paola Gualtieri, Giada La Placa, Giulia Frank, David Della Morte, Antonino De Lorenzo, and Laura Di Renzo. 2024. "The Relationship between Exposome and Microbiome" Microorganisms 12, no. 7: 1386. https://doi.org/10.3390/microorganisms12071386

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop