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Applied Sciences
Volume 12
Issue 21
10.3390/app122111170
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Article
Peer-Review Record

Biological Monitoring via Urine Samples to Assess Healthcare Workers’ Exposure to Hazardous Drugs: A Scoping Review

Appl. Sci. 2022, 12(21), 11170; https://doi.org/10.3390/app122111170
by Chun-Yip Hon * and Naqiyah Motiwala
Reviewer 1:
Daniela Pigini
Reviewer 2:
Saibal Majumder
Appl. Sci. 2022, 12(21), 11170; https://doi.org/10.3390/app122111170
Submission received: 13 October 2022 / Revised: 28 October 2022 / Accepted: 2 November 2022 / Published: 4 November 2022
(This article belongs to the Special Issue Recent Research in Occupational Exposure Assessments and Hazard Control Measures)

Round 1

Reviewer 1 Report

·      The aim of the paper is focused on highlighting the relevance of the biological monitoring to antineoplastic drugs as it allows to assesses all possible routes of workers’exposure; nevertheless the urine sampling is currently not routine.

 ·         The title of the article concerns the workers’ exposure to hazardous drugs (defined by the Directive (EU) 2022/431 of the European Parliament and of the Council of 9 March 2022) whilst the article refers only to the class of antineoplastic drugs. It is suggested to replace the title changing the term dangerous drugs with antineoplastic drugs.

 ·         Paragraph 1 “Introduction”: it should be noted that the artiche refers always to the NIOSH document of 2004. The Alert of 2004 contains a sample list of drugs identified by NIOSH as hazardous to workers in healthcare settings; however NIOSH has updated Lists in 2010, 2012, 2014, 2016, and in 2020. For this reason it would be appropriate also to mention the draft of the NIOSH List of Hazardous Drugs in Healthcare Settings, 2020 (https://www.cdc.gov/niosh/docket/review/docket233c/pdfs/DRAFT-NIOSH-Hazardous-Drugs-List-2020.pdf).

 ·         Rows 30 and 31: antineoplastic drugs and chemotherapy drugs  are analogous terms.

 ·         Row 114 and 115: delete.

 ·         Paragraph 3 “Results”: indicate the three databases in the same order as Figure 1 and correct the data reported in Figure 1 (the calculation of the number of excluded articles is not clear) in accordance with indicated in Paragraph 3.

 ·         Row 162: insert the full name of the drugs and the acronym in brackets

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments

1.      The main contribution of the manuscripts should be precisely emphasize in the penultimate paragraph under the Introduction section

2.      Figure 1 should have an improved resolution of at least 300 dpi

3.      The discussion section should be relatively more illustrative with respect to any graphical interpretation (e.g. pie chart, bar chart, etc.)

4.      The conclusion section should be more result oriented

5. The future scope should be written in a separate paragraph under the Conclusion section.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

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